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Volume 36, Issue 10
Displaying 51-74 of 74 articles from this issue
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FRANK SEELA, KLAUS KAISER1988 Volume 36 Issue 10 Pages 4153-4156
Published: October 25, 1988
Released on J-STAGE: May 27, 2011
JOURNAL FREE ACCESS4-Amino-1-(2, 3-dideoxy-β-D-glycero-pentofuranosyl)-1H-pyrazolo [3, 4-d] pyrimidine (5) was synthesized from 8-aza-7-deaza-2'-deoxyadenosine (1). Benzoylation of the 4-amino group of 1 followed by 4, 4'-dimethoxytritylation of the 5'-hydroxyl function gave 2b. Barton deoxygenation of the phenoxythiocarbonyl compound 3 afforded 4a and yielded 5 after removal of the protecting groups. The N-glycosylic bond stability of 5 to acid was higher than that of 2', 3'-dideoxyadenosine (ddA). Compound 5 showed no appreciable activity against human immunodeficiency virus. It was converted into allopurinol 2', 3'-dideoxyribofuranoside (6) by adenosine deaminase but at a lower rate than the conversion of ddA into ddl.View full abstractDownload PDF (564K) -
MASAHIRO TAGUCHI, YUKINOBU YAMANE, NORIO AIKAWA, GORO TSUKAMOTO1988 Volume 36 Issue 10 Pages 4157-4161
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSAssignments of labile protons (NH, OH-1, OH-4 and OH-8) and naphthalene carbon atoms in the 1H-and 13C-nuclear magnetic resonance spectra of rifampicin (1) and 3-[(dimethylhydrazono)-methyl] rifamycin SV (2) in CDC13 were made based on long-range selective decoupling experiments. The published assignments of the labile protons and two naphthalene carbon atoms (C-5 and C-9) of 1 should be revised.View full abstractDownload PDF (649K) -
YOSHITSUGU ARAI, MASANORI TAKADOI, TORU KOIZUMI1988 Volume 36 Issue 10 Pages 4162-4166
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe Diels-Alder reaction of menthyl (Z)-(S) s-3-(2-pyridylsulfinyl) propenoate with cyclohexa-1, 3-diene in the presence of a Lewis acid, zinc bromide, afforded the endo cycloadduct in a highly diastereoselective manner in excellent yield. The absolute stereochemistry of the adduct was determined by transformation into (+)-bicyclo [2.2.2] oct-5-ene-2-endo-methanol with known absolute configuration.View full abstractDownload PDF (821K) -
RYOJI KASAI, SATOMI HIRONO, WEN-HUA CHOU, OSAMU TANAKA, FENG-HUAI CHEN1988 Volume 36 Issue 10 Pages 4167-4170
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSFrom leaves of Engelhardtia chrysolepis, a Chinese sweet tea, a set of the diastereomers of astilbin (3-O-α-L-rhamonosyl-(2R, 3R)-taxifolin) was isolated together with eucryphin and quercitrin. Of these isomers, 3-O-α-L-rhamnosyl-(2S, 3S)-taxifolin (neoastilbin) was found to taste sweet. This is the first discovery of the sweetness of a dihydroflavonol glycoside.View full abstractDownload PDF (531K) -
JUN-EI KINJO, TAKASHI TAKESHITA, TOSHIHIRO NOHARA1988 Volume 36 Issue 10 Pages 4171-4173
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSA tryptophan derivative, N-acyl-N1-glucosyltryptophan, was isolated from Puerariae Flos.View full abstractDownload PDF (364K) -
HIROSHI FUKUI, KATSUMI GOTO, MAMORU TABATA1988 Volume 36 Issue 10 Pages 4174-4176
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSA new prenylated flavanone named licoflavanone was isolated, together with pinocembrin, from the leaves of Glycyrrhiza glabra var. Typica as an antimicrobial agent.View full abstractDownload PDF (422K) -
HIROYUKI YAMAGUCHI, HIROMICHI MATSUURA, RYOJI KASAI, OSAMU TANAKA, MOT ...1988 Volume 36 Issue 10 Pages 4177-4181
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe composition and contents of neutral and acidic saponins of Chinese and Japanese wildginseng were analyzed by high-performance liquid chromatography and two-dimensional thin layerchromatography. There was no significant difference in the major saponins between wild andcultivated specimens. It is noteworthy that the content of ginsenoside-Ro, the glucuronide saponinof oleanolic acid, is remarkably high in the rhizome and main root of Chinese wild ginseng.View full abstractDownload PDF (666K) -
TADAHIRO SHIKIMI, SUMIO MASUMURA1988 Volume 36 Issue 10 Pages 4182-4186
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe activities of thiol proteinases and their endogenous inhibitors in musculus rectus femoriswere studied in control and exercised rats of various ages. Cathepsins B and H, both lysosomal thiolproteinases, showed different age-related changes in activity. Two forms of calcium-activatedneutral protease (CANP), μCANP and mCANP, differ from the lysosomal thiol proteinases withregard to age-related changes in activity. The activities of endogenous inhibitors of CANP, cathepsins B and H are apparently not affected by age. Among CANP, cathepsins B and H, only theactivity of CANP (the sum of μCANP and mCANP activities) in the 16-week-old rats was reducedafter training. Exercise had no effect on the activities of endogenous inhibitors in the 16-week-and98-week-old animals. The relative percentage of the activity of μCANP to the activities of μCANPplus mCANP did not change regardless of differences of age or exercise. These findings suggest thatfactors other than endogenous inhibitors may be involved in the age- and exercise-related changesin the activities of these thiol proteinases, and also that there is a close relationship between μCANP and mCANP in skeletal muscle.View full abstractDownload PDF (823K) -
KATSUMI SAITO, JUNICHI ANDO, MASAHITO YOSHIDA, MAKOTO HAGA, YURIKO KAT ...1988 Volume 36 Issue 10 Pages 4187-4191
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe effect of sialoglycopeptide (GP) derived from fetuin on the tissue distribution of [3H] inulin-containing small unilamellar vesicles (SUV) was examined in rats. As the amount of GPcovalently bound to the SUV was increased, the liver uptake of GP-SUV decreased, while theirlevel in the blood increased. No significant difference in the [3H] inulin levels in heart, kidney, lungand spleen was observed after administration of control or GP-SUVs. These results suggest thatsurface modification of SUV with fetuin GP selectively alters their hepatic uptake. This may be a useful technique for designing liposomes with a long circulation time.View full abstractDownload PDF (758K) -
USA GLAGASIGIJ, YUKIO SATO, YASUO SUZUKI1988 Volume 36 Issue 10 Pages 4192-4198
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSComplement-mediated immunolysis was employed to examine the effect of incorporation ofvarious cholesterol analogues, having a terminal hydroxyl group or terminal primary amine groupat the 3-position of the cholestene nucleus, into the bilayer membrane of haptenated reverse-phaseevaporation vesicles. An enhancement of immunolysis was observed when triethoxycholesterol (analogue II) was incorporated, while no measurable change was detected when the chain length ofthe substituted groups in hydroxy cholesterols was shorter than that of analogue II. However, foramino cholesterol analogues, a remarkable decrease in immunolysis was seen. These results mayarise from changes of membrane properties such as bilayer fluidity, lateral hapten mobility and complement fixation.View full abstractDownload PDF (1024K) -
YORISHIGE IMAMURA, YUICHIRO KOJIMA, MASAKI OTAGIRI1988 Volume 36 Issue 10 Pages 4199-4202
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSSpecies difference in the in vitro metabolic reduction of acetohexamide, an oral antidiabeticdrug, was investigated using the rabbit, guinea pig, hamster, rat and mouse. The rabbit exhibitedthe highest acetohexamide reductase activity in cytosol of the liver and kidney among the speciestested. The sensitivities to specific inhibitors of cytosolic acetohexamide reductase in the liver andkidney of the rabbit were different from those of the rat. Furthermore, species difference inacetohexamide reductase activity was found in the microsomes of the liver and kidney; only the rat and guinea pig showed significant activity.View full abstractDownload PDF (497K) -
TAKAO KANEKO, SHUN-ICHIRO NAKANO, KAZUHIKO KAJI, MITSUYOSHI MATSUO1988 Volume 36 Issue 10 Pages 4203-4205
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSCytotoxicities of autoxidized polyunsaturated fatty acids toward human umbilical veinendothelial cells were examined. Autoxidized linoleic acid is more toxic than linoleic, autoxidizedlinolenic, or autoxidized arachidonic acid. Autoxidized linolenic acid is less toxic than linolenicacid. Autoxidized arachidonic acid is as toxic as linolenic or arachidonic acid. It was found thatmajor toxic components in autoxidized linoleic acid are linoleic acid hydroperoxides, and that a major component in autoxidized arachidonic acid is (E)-4-hydroxy-2-nonenal.View full abstractDownload PDF (447K) -
YASUO FUJIMOTO, MITSURU SATOH1988 Volume 36 Issue 10 Pages 4206-4208
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSA new chlorine-containing polyacetylene (3) and panaxydol (4) have been isolated from the callus of Panax ginseng, The structure of 3 was confirmed by its 1H-nuclear magnetic resonance (NMR), 13C-NMR and mass spectral data. The new acetylene exhibited growth inhibition against leukemia cells (L-1210) in tissue culture.View full abstractDownload PDF (406K) -
Yuji Hanzawa, Seiji Ishizawa, Yoshiro Kobayashi1988 Volume 36 Issue 10 Pages 4209-4212
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSReactions of the esters of trifluoromethylated allylic alcohol derivatives (1, 2, 3, and 4) with malonate anion in the presence of palladium catalyst and their use in synthesizing trifluoromethylated chrysanthemic acid are described.View full abstractDownload PDF (393K) -
Yoko Kanazawa, Satoru Kuribayashi, Masaharu Kojima, Terushi Haradahira1988 Volume 36 Issue 10 Pages 4213-4216
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe metabolic pathway of 2-deoxy-2-fluoro-D-galactose (FDGal) in mice was studied by 19F NMR. Efficient accumulation of FDGal in liver was demonstrated by NMR, which is consistent with the results of Ishiwata et al. using radioactive 18FDGal. The new discovery is that this fluorinated hexose was converted to 2-deoxy-2-fluoro-D-glucose (FDG) through UDP-FDGal and UDP-FDG apparently by the action of UDP-Gal epimerase.View full abstractDownload PDF (447K) -
Kyung Soo Ko, Yutaka Ebizuka, Hiroshi Noguchi, Ushio Sankawa1988 Volume 36 Issue 10 Pages 4217-4220
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSTransformation of plants belonging to several families was investigated with Agrobacterium rhizogenes which harbours Ri plasmids and transfers T-DNA into the plant genome. Transformed Nicotiana tabacum had typical hairy roots, whereas Cassia torosa, C. occidentalisand C. obtusifolia had rather thick hairy roots lacking finelateral branching. The hairy roots of N. tabacum regenerated plants with typical phenotypes of Ri plasmid transformants. The nicotine content in the leaves of the regenerants were the highest in the plant that showed a heavily transformed phenotype. The hairy roots of Cassia plants produced anthraquinones and a xanthone, whose production profiles basically reflected those of the parent plant roots.View full abstractDownload PDF (525K) -
Naoki Takeuchi, Toshio Kasama, Kiyoshi Mayuzumi, Kenji Tamaru, Hiroaki ...1988 Volume 36 Issue 10 Pages 4221-4224
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSCrude coumarin constituents of Peucedanum praeruptorum Duun. including praeruptorin A (=Pd-Ia)(2) and B (=Pd-II)(11) had an antagonistic effect on a specific platelet activating factor (PAF) in the platelet aggregation induced by several aggregating agents. This provides a new class of PAF antagonists. Studies of the structure-activity relationship with khellactone (1) derivatives and PAF antagonistic activity indicate that the cis isomers of 1 at the C-3' and C-4' positions are more favorable than trans isomers, and the acyl moiety at the C-3' position of 1 requires an appropriate molecular size.View full abstractDownload PDF (533K) -
Takashi Hakamatsuka, Hiroshi Noguchi, Yutaka Ebizuka, Ushio Sankawa1988 Volume 36 Issue 10 Pages 4225-4228
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSChalcone synthase of Pueraria lobata cell cultures treated with an endogenous elicitor afforded isoliquiritigenin, a deoxy-type chalcone, from p-coumaroyl and malonyl CoAs in the presence of NADPH. But naringenin chalcone, a hydroxy-type chalcone, was the sole reaction product when NADPH was omitted from the reaction mixture. At lower NADPH concentrations, the formation of isoliquiritigenin was proportional to the concentration of NADPH and reached its maximum at ca. 1 mM. The total amount of the chalcones formed was constant throughout the range of 0 to 4 mM NADPH. These results seem to indicate that a single deoxychalcone synthase (DOCS) gives either isoliquiritigenin or naringenin chalcone depending upon the presence or absence of NADPH.View full abstractDownload PDF (551K) -
Shingo Yasuda, Youichi Yamamoto, Shuji Yoshida, Miyoji Hanaoka1988 Volume 36 Issue 10 Pages 4229-4231
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS(±)-Cephalotaxinamide (6) was synthesized from pyroglutamic acid via the pyrrolobenzazepine (4) through the Claisen rearrangement, the Wacker oxidation, aldol condensation, and hydroxylation with iodosobenzene.View full abstractDownload PDF (339K) -
Isao Kitagawa, Hirotaka Shibuya, Nam In Baek, Yoshihiro Yokokawa, Aya ...1988 Volume 36 Issue 10 Pages 4232-4235
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSA new bitter trimeric-iridoid diglucoside named pulosarioside (1) was isolated from an Indonesian folk-medicine (Jamu, “pulosari” ), the air-dried bark of Alyxia reinwardtii BL.(Apocynaceae), and the absolute configuration of 1 has been determined on the basis of chemicaland physicochemical evidence.View full abstractDownload PDF (639K) -
Masayuki Yoshikawa, Bae Cheon Cha, Yoshihiko Okaichi, Yoshihiko Takina ...1988 Volume 36 Issue 10 Pages 4236-4239
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSUsing as a key reaction a Michael-type addition reaction to nitroolefins or a substitution reaction for an acetoxyl residue at the β-position of the nitro group in pseudo-nitro-sugar, three optically active pseudo-amino-sugars: validamine, epi-validamine, and valienamine, were synthesized from D-glucose.View full abstractDownload PDF (552K) -
Hiroyuki Sawanishi, Shuichi Saito, Takashi Tsuchiya1988 Volume 36 Issue 10 Pages 4240-4243
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSPhotolysis of the 3-methoxy-4-azidopyridazines (1) in the presence of a base such as methoxide ion and diethylamine resulted in ringexpansion to form the corresponding unstable 1H-1, 2, 5-triazepines (3 and 1), which were tautomerized to the relatively stable 4H-isomers 5 and 6 by further treatment with sodium methoxide. Treatment of the 1H-triazepines (3 and 4) with acetyl chloride in pyridine gave the stable 1-acetyl-1H-1, 2, 5-triazepines (7 and 8). The products 5-8 are the first examples of isolated 1, 2, 5-triazepines.View full abstractDownload PDF (453K) -
Noriyuki Nakajima, Reiko Abe, Osamu Yonemitsu1988 Volume 36 Issue 10 Pages 4244-4247
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSNew protecting groups for the hydroxy function, 3-methoxybenzyl (3-MPM) and 3, 5-dimethoxybenzyl (3, 5-DMPM) groups are slowly removed by DDQ oxidation at room temperature and distinguished from readily removable 4-methoxybenzyl (MPM). They are stable to strong acids.View full abstractDownload PDF (443K) -
Miyoji Hanaoka, Masumi Kohzu, Shingo Yasuda1988 Volume 36 Issue 10 Pages 4248-4251
Published: October 25, 1988
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS(±)-Raddeanone (1) was stereoselectively synthesized from the corresponding protoberberine (5) via the ketal (17) in four steps. Inversion of a hydroxyl group in the ketal (17) was realized by the neighboring-group participation of a urethane to afford the diastereoisomeric ketal (22), which was easily converted to (±)-yenhusomidine (3). These alkaloids (1 and 3) were converted to (±)-raddeanine (18), (±)-raddeanidine (20), and (±)-yenhusomine (25).View full abstractDownload PDF (512K)