Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 53, Issue 9
Displaying 1-8 of 8 articles from this issue
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Original Articles
  • ‘Basal-Plus Therapy’ Effectiveness with Insulin Glulisine in Glycemic Control and QOL
    Tetsuji Niiya, Akiko Hashimoto, Shinako Horimi, Mari Nishiyama, Takash ...
    2010 Volume 53 Issue 9 Pages 675-679
    Published: 2010
    Released on J-STAGE: October 15, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.53.675
    JOURNAL FREE ACCESS
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    We studied Basal-plus therapy effectiveness with the new rapid-acting insulin analog insulin glulisine. Subjects were 17 persons with type 2 diabetes and poor HbA1c levels undergoing basal-supported oral therapy (BOT) . Subjects were administered added insulin glulisine at the evening meal. After 12 weeks of treatment, the insulin glulisine dosage was 4.8 ±1.4 unit. HbA1c decreased significantly at 7.4 ±0.8% to 7.0 ±0.7%, P<0.001, while BMI (23.1 ±3.7 to 23.2 ±3.4 kg/m2, P=0.839) and hypoglycemia frequency (1.2 ±3.0 to 0.9 ±1.4 times/month, P=0.729) did not change significantly. We evaluated quality of life (QOL) with the insulin-therapy-related QOL measure questionnaire (ITR-QOL) . After 12 weeks, the number of insulin injections increased, but ITR-QOL did not worsen significantly (99.2 ±12.1 to 97.1 ±15.4, P=0.331) . These results suggest that basal-plus therapy with insulin glulisine aids in glycemic control and QOL in those with type 2 diabetes.
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  • Eicosapentaenoic Acid/Arachidonic Acid Ratio versus Malondialdehyde-Modified Low-Density Lipoprotein in Diabetes Mellitus
    Tsutomu Araki, Taketsugu Tsuchiya
    2010 Volume 53 Issue 9 Pages 680-685
    Published: 2010
    Released on J-STAGE: October 15, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.53.680
    JOURNAL FREE ACCESS
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    Eicosapentaenoic acid (EPA) treatment is recommended by the Japan Atherosclerosis Society for high-risk hypercholesterolemic subjects, including those with diabetes mellitus. A high ratio of plasma EPA to arachidonic acid (AA) is reported to reduce coronary event incidence. Serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) , a major component of oxidized LDL, is a useful marker for predicting coronary events in those with diabetes. We studied the relationship between the EPA/AA ratio and serum MDA-LDL concentration in 60 subjects with type 2 diabetes mellitus divided into group A (n=30, EPA/AA ratio <0.5) and group B (n=30; EPA/AA ratio ≥0.5). Serum MDA-LDL was significantly higher in group A than in group B (86 ±22 U/L vs 73 ±20 U/L) . Serum MDA-LDL decreased significantly from 92 ±27 U/L at baseline to 70 ±23 U/L in 12 group A subjects administered 1,800 mg of EPA daily for 3 months after EPA treatment, with the EPA/AA ratio increasing from 0.35 ±0.08 to 1.20 ±0.53. These results suggest that EPA treatment may reduce the oxidative stress observed in those with diabetes and a low EPA/AA ratio.
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Case Reports
Co-medicals; Original Article
  • 1 : 1 : 1 Lunchbox—New Dietary Regimen for Energy-controlled Diets
    Hiroki Fujimoto, Shinya Fukumoto, Yohei Mima, Mika Harima, Tomoko Kita ...
    2010 Volume 53 Issue 9 Pages 706-712
    Published: 2010
    Released on J-STAGE: October 15, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.53.706
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    In studying energy-controlled box lunches for diabetics, we nutritionally analyzed 414 diets using 111 and 312 lunches having ratios of staples, main dishes, and side dishes of 1 : 1 : 1 and 3 : 1 : 2. Carbohydrates in 111 fares accounted for 57.5±7.9% and in 312 fares for 65.6±7.7%. The 111 fare was thus adequate for a diabetes diet. Because dietary energy correlates strongly with lunchbox capacity, diets close to targeted energy could be created based on lunchbox capacity. Because meal weight correlates strongly with dietary energy, energy could be estimated based on weight meal. Multiple regression analysis found independent factors affecting dietary energy to be capacity, weight, ratios of staple and main and side dishes, and dietary fat, with 93.2% of energy accounted for by these factors. Adequate diabetic diets can thus be created based on the 111 lunchbox capacity corresponding to targeted dietary energy and final weight, creating a useful self-learning procedure for easy dietary diabetes treatment.
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  • Attitude Survey on Diabetic Nursing Questionnarie
    R. Tominaga, C. Matsumoto, N. Matsuyama, Y. Yanagihara, H. Yamaguchi, ...
    2010 Volume 53 Issue 9 Pages 713-718
    Published: 2010
    Released on J-STAGE: October 15, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.53.713
    JOURNAL FREE ACCESS
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    [in Japanese]
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