The glycated albumin (GA) level in 414,909 blood donors in Japan was analyzed in relation to sex, age and body mass index (BMI). As donor age increased, the proportion of donors with GA ≥16.5% increased both in males and females. The mean GA level in young donors decreased with BMI within the normal GA level range. In donors ≥30 years of age, the mean GA level increased with age even in the subpopulation with a low BMI, whereas both the proportion of donors with GA ≥16.5% and the mean GA level increased with age in the subpopulation with a high BMI. It is suggested that even in the young generation, the risk of having diabetes mellitus will increase after 30 years of age if the state of having a BMI ≥30 lasts for a long time. It was also found that people with low to normal BMI represent 60% of those with GA ≥16.5%, indicating the presence of a considerable number of people with impaired glucose tolerance in Japan. The measurement of GA level in all blood donors will greatly contribute to the early detection of people with prediabetes mellitus and the prevention of the disease.

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We evaluated the long term efficacy of insulin Detemir by switching the basal insulin from NPH to Detemir, with the same dose and timing, in this observational study. 103 Japanese type 2 diabetes patients were enrolled in the study, who had continued the maximum daily dose intensive insulin therapy which led basically no hypoglycemia. Finally 81 patients completed the study. Aiming at a fasting blood glucose level of less than 110 mg/dl, we could increase the average dose of Detemir from 8 units (6-12 units) to 12 units (8-19.5 units), without any increase in weight and frequency of hypoglycemia. HbA1c was improved significantly, and the improvement was maintained for 18 months.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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We examined the relationship between executive functional levels in sixty-five diabetic patients and their self-care behaviors. We used the Japanese version of the Behavioral Assessment of Dysexecutive Syndrome (BADS) to assess the executive function. The Japanese version of the "Summary of Diabetes Self-Care Activities Measure" (J-SDSCA) was employed for the assessment of self-care behaviors. Although no correlation was noted between the patients BADS and J-SDSCA scores, negative correlations were observed between the Rule Shift Cards/Action Program Tests and J-SDSCA scores. A negative correlation was noted between the Temporal Judgment Test scores and HbA1c levels. A part of the result of the executive function was related with both the positive and negative aspects of the self care behaviors. Therefore, there is no problem for those patients un whom the executive functional level decreased, but who became accustomed to self-care behavir. However, when the behavior modification required changing the method of treatment, it is assumed that it is probably difficult for patients to modify their behavior.

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