Purpose: The present study determined the association between physical activity (PA) and the lower extremity function in patients with type 2 diabetes mellitus (DM). Methods: The study design was a cross-sectional study of 149 outpatients with type 2 DM. Participants were instructed to wear an accelerometer for seven consecutive days, and we monitored eight indicators, including four concerning the amount of physical activity, three concerning exercise, and one concerning the daily step count. The lower extremity function was determined by performing the sit-to-stand test five times, and we evaluated the relationship between PA indicators and the lower extremity function by a logistic regression analysis. Results: Only daily steps were significantly associated with the lower extremity function (odds ratio: 1.016, 95 % confidence interval: 1.005-1.028, unit change: 100 steps); the other PA indicators were not associated with the lower extremity function. Conclusion: Achieving a set number of daily steps is important for maintaining the lower extremity function in patients with type 2 DM.

We herein report a patient with acute onset type 1 diabetes mellitus that developed three months after delivering a child with depletion of insulin secretion just after the onset. This patient was a 32-year-old woman who recognized excessive thirst, polydipsia, polyuria and digestive symptoms. She visited the emergency room in our hospital, and her laboratory findings showed that her blood glucose level was 664 mg/dL, HbA1c 9.7 %, urine ketone bodies (3+), venous blood gas pH 7.018, fasting-serum C peptide 0.41 ng/mL, and islet cell antibody (ICA) 20 JDF units. We diagnosed her with autoimmune acute-onset type 1 diabetes with diabetic ketoacidosis (DKA). Her HLA-typing was DRB1*04: 05-DQB1*04: 01, which indicates susceptibility to Japanese type 1 diabetes. Her insulin secretion further deteriorated and was almost completely lost just 10 days after the onset. We considered her beta cell destruction to have been accelerated after the onset of acute-onset type 1 diabetes (autoimmune).