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Volume 42, Issue 4
Displaying 1-12 of 12 articles from this issue
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Akitaka Shibuya, Masaaki Watanabe1999 Volume 42 Issue 4 Pages 259-262
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese]1999 Volume 42 Issue 4 Pages 263-266
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese]1999 Volume 42 Issue 4 Pages 267-269
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese]1999 Volume 42 Issue 4 Pages 271-273
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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Hisaya Tada, Kayoko Nomura, Koji Kuboki, Toshiki Inokuchi, Sho Isogai1999 Volume 42 Issue 4 Pages 275-279
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe investigated the effects of troglitazone (Tr) on the proliferation and synthesis of transforming growth factor-β(TGF-β) and fibronectin in human mesangial cells (MC) cultured with either low or high levels of glucose. Treatment of MC with Tr caused a decrease in both DNA content and [3H]-thymidine uptake in the cells cultured with concentrations of 5mM and 33mM glucose. Incubation of MC with 33mM glucose resulted in an increase in the production of TGF-β and fibronectin compared with 5mM glucose. However, the high glucose-induced increase in TGF-β and fibronectin was halted by Tr. Accordingly, the effects of Tr on these MC functions may justify its clinical trial for treatment of diabetic nephropathy.View full abstractDownload PDF (767K) -
Tatsuhiko Urakami, Hiroko Matsunaga, Yukinobu Miyamoto, Hidehiro Fujit ...1999 Volume 42 Issue 4 Pages 281-288
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe investigated the clinical characteristics at the time of diagnosis of slowly progressing IDDM in 44 children that was detected by chance through urine glucose screening at school.
(1) Female predominance (66%) was distinct. In the majority of cases, onset was in adolescence.(2) The average BMI was 17.0±1.7kg/M2, and no case of obesity was found.(3) A family history of NIDDM (36%) among their first-degree relatives was found.(4) Deterioration in pancreatic β-cell function and metabolic disorder were milder than in abrupt onset IDDM.(5) The incidence of antibodies against pancreatic β-cells was approximately 60% with low antibody titers.(7) Associations of DR 4, DQB 1*0401 (susceptible) and DR 2, DQB 1*0602 (protective) were not significant in contrast to abrupt onset IDDM.
These findings indicate the heterogeneity in the clinical course of IDDM, and the possibility of two different subtypes in Japanese children, i.e. acute and slow clinical forms.View full abstractDownload PDF (1415K) -
Kazuyo Tsushita, Mitsuro Niinomi, Hideki Okamoto, Shuji Imamura, Hiros ...1999 Volume 42 Issue 4 Pages 289-297
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo evaluate the quanitity and quality of physical activity of diabetic patients, we used a unique pedometer (CAL-D, manufactured by Suzuken Co., Ltd. in Japan), which memorizes caloric consumption by physical movement, total number of steps and intensity of physical movement for 30 days. The data were sent by the infrared transmitter of the device to a personal computer. The maximum, minimum and average steps per day during the past 30 days, accumulated duration of physical activity, caloric consumption by physical movement were then calculated by a personal computer. Graphic display of physical movement variability during 24 hours made it easy to confirm duration, time course and intensity of each patient's exercise. One hundred forty-three diabetic patients without diabetic micro-and macroangiopathy were studied. Differences of physical activity by sex, age, BMI or occupation can be displayed objectively. Patients who had attended exercise programs prior to the study were more active than those who had not. The results of our study show this method is effective in evaluating physical activity, and practical in educating patients about exercise.View full abstractDownload PDF (1453K) -
Yasuo Kida, Natsuki Harada, Katsuhiko Sakamoto, Touru Kawabata, Mari J ...1999 Volume 42 Issue 4 Pages 299-304
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe case was a 51-year-old male with type-2 diabetes with autonomic neuropathy, preproliferative retinopathy and mild hypertension. The duration of diabetes was 20 years. His hyperglycemia was poorly controlled with insulin. No abnormal finding was found on plain chest x-ray, however, electrocardiography indicated left ventricular hypertrophy and myocardial ischemia without clinically evident heart disease. In addition, M-mode ECHO and pulsed Doppler cardiography indicated abnormalities of both the left ventricular systolic and diastolic functions. Although no significant stenosis of major coronary vessels was found on angiography, the wall motion of the left ventricle was diffusely impaired. Diagnosis of diabetic cardiomyopathy was made by the results of these examinations, and cardiac muscle biopsy was performed, which proved arteriolar wall thickness with hyalinization and luminal stenosis. After having dinner on Dec. 31, 1995, he died suddenly while watching TV at home. Although the precise mechanism of the death was not clear, acute pump failure (cardiac arrest) or ventricular fibrillation due to cardiomyopathy may have been the cause of sudden death. These findings suggest that diabetic cardiomyopathy, like idiopathic cardiomyopathy, may be a possible cause of sudden death in diabetic patients.View full abstractDownload PDF (1388K) -
Keiji Tanaka, Akira Kanamori, Yoshitada Yajima1999 Volume 42 Issue 4 Pages 305-310
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 62-year old man with a 15-year history of untreated diabetes mellitus initially visited another hospital because of miction pain. He was diagnosed with urethritis and treated with antibiotics Pipecacillin Sodium without improvement. He was admitted to our hospital with persistent fever, diabetic ketoacidosis and sepsis caused by Methicillin resistant staphylococcus aureus (MRSA). Diagnostic CT revealed prostatitis, and we subsequently detected sepsis related to prostatitis. On hospital day 7, white pus caused by MRSA was discharged from the anus. Various diagnostic imaging procedures revealed a prostatic abscess and rectoprostatic fistula. Although improvement was obtained by withholding food and administering antibiotics (Amikacin Sulfate), the patient experienced lower back pain, and a blood examination showed an increased innammatory reaction on hospital day 28. MRI revealed pyogenic vertebral osteomyelitis. By hospital day 204, all symptoms resolved with a change in antibiotics (Minocycline Hydrochloride). These findings suggest that the lower urinary tract infection, in the present case, may have spread to the vertebra and its surrounding tissue through hematogenous dissemination. In managing such a case, the physician must keep in mind the possibility that the condition may become severe if it involves MRSA.View full abstractDownload PDF (2090K) -
Satoshi Tada, Noriyuki Kuroda, Toshihiro Inage, Tatsushi Kajikawa, Tos ...1999 Volume 42 Issue 4 Pages 311-314
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe developed a rapid analytic method (hemolyzing tube method) for HbA1c determination using a dedicated hemolyzing tube that allows the blood sample to hemolyze at the time of blood drawing. Based on a turbidimetric inhibition immunoassay (TINIA) method, LIQUITECH HbA1c II (Roche Diagnostics K.K.), was used to measure HbA1c. Precision by the hemolyzing tube method was CV=1.62%(n=10). Results of a comparison study between HPLC (x) and hemolyzing tube method (y) were y=1.045x-0.167, r=0.982 (n=260).
In conclusion, a hemolysis sample can be easily and rapidly obtained with this newly developed hemolyzing tube method, which is convenient for the laboratory and particularly suitable for rapid testing of HbA1c.View full abstractDownload PDF (1063K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 4 Pages 315-317
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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1999 Volume 42 Issue 4 Pages 319-333
Published: April 30, 1999
Released on J-STAGE: March 02, 2011
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