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Volume 17, Issue 6
Displaying 1-9 of 9 articles from this issue
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Toshihiko Mihara, Tadasu Kasahara, Masato Tominaga, Yoshihiro Kimura, ...1974 Volume 17 Issue 6 Pages 489-495
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFrom Jan. 1970 to June 1973, the deaths of 129 patients with primary diabetes who had been treated in our hospitals located in San-in Area of Japan were recorded. The present report deals with the cause of death. Among them, 95 died during hospitalization and the rest (34) at home.
The most frequent cause of death was diabetic nephropathy, followed by cerebrovascular disease, malignant neoplasms and ischemic heart disease. Ischemic heart disease significantly increased in proportion as the cause of death when compared with the cause of death calculated from control subjects selected from the total dead cases in the general population of Tottori Prefecture in 1971 whose sex and age were matched with the 129.
The most frequent cause of death in 95 patients who died in hospital was ischemic heart disease, while diabetic nephropathy was the highest cause of death in the other 34 patients who died at home.
Of the total cases, 9 were complicated with diabetic gangrene. The incidence rate of gangrene among the dead cases of diabetes in this area seems much higher than the average in Japan. The percentage of dead cases due to vascular disease such as diabetic nephropathy, ischemic heart disease and cerebrovascular disease was much higher in cases associated with hypertension than that in cases without hypertension.
As a conclusion, the incidences of diabetic nephropathy and ischemic heart disease as death causes in diabetics were higher in San-in Area than in the other parts of Japan. Also diabetic gangrene was frequently observed in diabetic deaths in this area.View full abstractDownload PDF (1386K) -
Masami Nojiri1974 Volume 17 Issue 6 Pages 496-501
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSScreening for diabetes was performed for all the school boys and girls in Katsuura-city and Isumigun in Chiba Prefecture (7, 900 pupils of elementary school, 4, 829 of junior high school, 1, 451 of senior high school).
Partly fasting urine and partly postprandial urine were tested for glucose with Uristix, and 88 pupils were found to have glycosuria. The occurence of glycosuria increased from 0.3% to 2.0% with pupils age, particulary in the postprandial group. This seems to suggest that the renal threshold for glucose falls with age in some pupils.
Fortyg/m2 (body surface area) glucose tolerance test was given for 74 pupils with glycosuria and for 14 of the normal control group. According to the criteria of 50g GTT suggested by the Japan Diabetic Society, 12 pupils revealed borderline types and 56 normal types of the glucose tolerance curve, 14 of which showed glycosuria.
Only one pupil, a 14 years old girl, was found to be a diabetic. She had already been established in the screening of the preceding year and treated with insulin. Hence, the glucose tolerance test was considered unnecessary for her this year. Consequently, the overall frequency of diabetes among the pupils was approximately 0.01%.
Low blood sugar levels were detected in those with glycosuria, 2 and 3 hours after oral glucose load, but compared with normal controls, it was not a significant differnce.View full abstractDownload PDF (1248K) -
Ichiro Uematsu, Koji Nakamura, Masatoshi Naito1974 Volume 17 Issue 6 Pages 502-507
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe oral glucose tolerance test (OGTT) was performed in 70 subjects with a history of gastrectomy, and in several cases the serum immunoreactive insulin (IRI) was also determined during the test.
The results were as follows:
1) Eight cases were found to be diabetic, 27 cases were borderline, 35 cases were normal, and 31 cases were noted as having oxyhyperglycemia.
2) The incidence of oxyhyperglycemia was rare in the patients whose postoperative period was less than 6 months, but, it increased with the elapsing of the time, and was highest in patients whose post operative period was 1-2 years after gastrectomy. However, it then decreased, and little difference was seen in the patients with, more than 5 years after the gastrectomy.
3) The OGTT was traced for 0.5-2 years in 24 cases of gastrectomy. Of the 10 cases with oxyhyperglycemia, 3 cases have shifted to the diabetic type, 2 cases to normal, 3 cases to borderline type, and 2 cases have remained unchanged.
4) In the cases of oxyhyperglycemia, there was the possibility, that the glucose tolerance in the patients which showed low response of IRI to glucose shifted to the diabetic type, and the group with normal or hyperresponse of IRI continued unchanged or reversed to normal type.View full abstractDownload PDF (1306K) -
Yutaro Takamura, Tomoyuki Kono, Yoshiyuki Miyazaki, Osamu Suzuki, Hide ...1974 Volume 17 Issue 6 Pages 508-514
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIt is known that insulin response to the glucose load in non-diabetic obese persons becomes normal after a decrease in the body weight. However, changes in the insulin response of diabetic patients with a decrease in body weight due to diet regulation are not clarified as yet. Therefore, 22 cases of maturity-onset mild diabetes treated only by diet regulation were divided into group A (marked decrease in body weight) and group B (unmarked decrease in body weight) in order to compare the serum insulin response to glucose load (100 g) before and after a decrease in body weight.
1) In group A, the value for blood sugar showed a significant decrease at each measurement after a decrease in body weight, while the value for serum insulin showed a significant increase at 120 minutes. In group B, neither blood sugar nor serum insulin showed a significant change after a decrease in body weight.
2) After a decrease in body weight, group A showed a significant decrease in the glucose area, but no significant change in the insulin area. On the other hand, group B showed no significant change in either the glucose area or the insulin area after a decrease in body weight.
3) Group A showed a significant increase in insulinogenic index at each measurement after a decrease in body weight. Group B showed no significant change in insulinogenic index after a decrease in body weight.
From the above results, it is considered that successful decrease in body weight of a diabetic due to diet regulation is accompanied by an increase in insulin secretion.View full abstractDownload PDF (1188K) -
Toyozo Sakurada, Hajime Orimo, Hiroaki Okabe, Akio Noma, Mototaka Mura ...1974 Volume 17 Issue 6 Pages 515-521
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn an attempt to clarify the alteration in aortic lipid synthesis in diabetes, aortas from rats with streptozotocin-induced diabetes were incubated with 14C-glucose and the incorporation of glucose into the lipid fractions was studied. After incubation, lipid was extracted and the chloroform and methanol fractions were analyzed for their composition and radioactivity.
In diabetic rats, in which streptozotocin (80 mg/kg) was given 4 days before sacrifice, the incorporation of glucose into the both fractions was significantly decreased when compared with the controls. However, these decreases were inhibited when the rats were given simultaneous administration of Novo lente insulin (15 iu/kg) and streptozotocin (80 mg/kg) for 4 days.
In rats in which streptozotocin (80 mg/kg) was repeatedly given for 28 days, the triglyceride content in the aorta was significantly decreased. However, the incorporation of glucose into the aortic triglyceride was not different from the controls.
These results suggest that the incorporation of glucose into the aortic lipid was altered in diabetes and could be reversed by insulin.View full abstractDownload PDF (1474K) -
Masumi Nozawa1974 Volume 17 Issue 6 Pages 522-524
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe long-term effects of pancreas transplantation on diabetic nephropathy have not been determined. The perfection of a technique for vascularized transplantation in the inbred rat pancreas with or without duodenum has made it possible to conduct such studies in our laboratory.
Diabetes was induced by administration of Streptozotocin (65mg) to rats. Urine protein determinations were performed weekly on 24 hour samples. Animals were biopsied as early as 2 months after the onset of diabetes and renal tissue was obtained for light microscopy (H & E, PAS, PAS silver methenamine and trichrome stain) and electron microscopy.
Significant alterations were observed from 2 months and increased in severity with time. These changes included an increase in mesangial matrix as demonstrated by light and electron microscopy. These changes were associated with a marked increase in protein excretion. Such changes were not observed in animals receiving pancreatic isografts following induction of diabetes.View full abstractDownload PDF (2367K) -
Yoshimasa Tasaka, Makio Sekine, Masako Wakatsuki, Masako Iwatani, Hisa ...1974 Volume 17 Issue 6 Pages 525-527
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPlasma pancreatic glucagon, insulin and glucose were measured hourly in four healthy adult subjects during a 24-hour period of daily life. The antiglucagon serum 30 K used for the immunoassay of pancreatic glucagon proved highly specific for pancreatic glucagon. Plasma glucose and insulin levels increased after each meal and were invariable during the night.
The increase of plasma insulin after supper was less than that after breakfast irrespective of its higher blood sugar level, suggesting a lower glucose tolerance in the evening. Plasma pancreatic glucagon showed a fairly constant level during day and night in normal subjects just as the total glucagon level reported by others.View full abstractDownload PDF (550K) -
1974 Volume 17 Issue 6 Pages 529-550
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (6168K) -
1974 Volume 17 Issue 6 Pages 551-563
Published: November 30, 1974
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3344K)
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