We shortened diabetic educational hospitalization from 4 to 3 or 2weeks and compared educational effects and glycemic control among the 3 groups. No significant difference was seen in FPG, HbAlc, or educational effect when patients were discharged. Significance was not accepted in HbAlc one year after discharge, either. Also, the program showed significant effects in education and glycemic control in these patients.

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1, 5-anhydroglucitol (1, 5 AG) reflects more recent blood glucose control than blood glucose regulation markers such as HbA1c, glycoalubumin, or fructosamine, and sensitively detects subtle blood glucose changes. To determine the relationship between 1, 5 AG and the development of diabetic retinopathy, we followed up 452 patients, who did not have diabetic retinopathy at the start of the study, for 8 years. We found a significant negative correlation between mean 1, 5 AG and the incidence of diabetic retinopathy (r=-0.254). A comparison of the incidence of diabetic retinopathy among the combinations of 4 groups stratifled by mean HbA1c and 2 groups stratified by mean 1, 5 AG showed that the incidence of diabetic retinopathy was significant higher in patients with 4.5μg/ml or less 1, 5 AG than in those with 1, 5 AG above 4.5μg/ml in the group with 7.2% or greater HbA_1c. Our findings suggest that both HbA1c and 1, 5 AG are useful predictors of diabetic retinopathy, and that considering 1, 5 AG improves the reliability of predicting the development of diabetic retinopathy in patients having high HbA1c.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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To clarify the clinical significance of urinary 8-hydroxydeoxyguanosine (8-OHdG), we measured urinary 8-OHdG by enzyme immunoassay in 73 patients with type 2 diabetes mellitus and 29 age-matched control subjects. We also studied the relationship between urinary 8-OHdG and different microproteins.
The mean urinary 8-OHdG in the 73 diabetic patients was 12.8± 5.1μg/g. Ecr, significantly higher thanthat in the 29 control subjects (7.6±4.3, μg/g. Ecr, p<0.001). Urinary 8-OHdG correlated with hemoglobin Aic (r=0.356, p=0.0018). In contrast, urinary 8-OHdG did not correlate significantly with indicators of glomerular injury such as urinary transferrin and type IV collagen (r=-0.144 and r=-0.061) or with indicators of tubulointerstitial injury such as urinary N-acetyl-β-D-glucosaminidase activity andβ 2-microglobulin (r=-0.082 and r=-0.125).
These results indicate that urinary 8-OHdG as an indicator of oxidative DNA damage may be affected by glycemic control rather than the severity of renal involvement withelevated urinary microproteins.

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We studied the acute effects of mechanical horseback riding therapy on glucose metabolism via euglycemicglucose clamp. Subjects were 5 healthy men. After 60 minutes of riding exercise, the glucose infusionrate (GIR) significantly increased (P<0.01) over resting time, and this continued at recovery. These resultssuggest that mechanical horseback riding therapy increased energy expenditure, and enhanced glucose uptaketo the skeletal muscles, especially the thigh, abdomen, and low-back muscles. This may thus be usefulin physical exercise therapy for patients with diabetes and lifestyle-related diseases.

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[in Japanese]

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