We determined the serum fructosamine (FRA), HbA
1c, and fasting plasma glucose (FPG) levels in 80 insulin-dependent diabetes mellitus patients (IDDM) aged from 3 to 27 years, and compared with those in 34 non-diabetic subjects of the same age.
The venous blood was collected at a single hospital visit, and FRA was measured using the Fructosamine Test (Roche).
1) FRA levels in children from 1 to 10 years old were low in both the non-diabetic and diabetic groups.
2) There was a significant correlation between FRA and HbA
1c levels (r=0.79) but there was less correlation between FRA and FPG levels (r=0.29). There was no correlation between FRA or HbA
1c and the weekly mean FPG levels of SMBG measured during the 4 weeks before, in 13 IDDM patients.
3) In the 13 IDDM patients undergoing SMBG testing for 4 weeks, FRA level was 3.99±0.69 mmol/
l (M±SD) and HbA
1c level was 8.9±1.1%. In the another 10 IDDM patients who had maintained good glycemic control during the previous 3 months, FRA level was 3.65±0.50 mmol/
l and HbA
1c was 7.8±1.0%.
The fluctuating plasma glucose in IDDM has a weak correlation with FRA, while FRA and HbA
1c have a strong correlation with each other. Therefore, fructosamine measurement may be useful as an indicator of glycemic control in diabetic children.
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