Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 52, Issue 10
Displaying 1-9 of 9 articles from this issue
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Original Article
  • Survey of Drug Therapy in Those with Type 2 Diabetes Mellitus (IV)-Insulin Treatment
    Injection Regimen Effectiveness and Rapid-acting Insulin Analog Efficacy(JDDM17)
    Azuma Kanatsuka, Koichi Kawai, Koichi Hirao, Mariko Oishi, Masashi Kob ...
    2009 Volume 52 Issue 10 Pages 821-828
    Published: October 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.821
    JOURNAL FREE ACCESS
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    We analyzed data from 42 institutes using CoDiC®, an electronic diabetes data collection and management system, to determine insulin injection regimen effectiveness and rapid-acting insulin analog (RA) efficacy on glycemic control in those with type 2 diabetes mellitus (T2DM). Out 22,307 subjects with T2DM registered in 2006, we analyzed data from 1,094 treated with insulin for 6 months or more. During this period, HbA1c decreased in those undergoing two injections/day of a 30% RA (30RA) or 30% regular insulin (30R) preparation-a decrease greater in those treated with 30RA. HbA1c markedly decreased in those undergoing prandial boluses of RA or R insulin. Basal-bolus insulin with RA or R insulin plus NPH insulin or long-acting insulin analog (LA) dramatically decreased HbA1c, particularly in those given RA. This shows that prandial and basal-bolus insulin maintain glycemic control more effective than two injections/day of mixed insulin preparations. Better glycemic control was attained with RA insulin than with R insulin.
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  • Differences in Renal Function Risk Factor Reduction and Microalbuminuria in Those with Type 2 Diabetes
    Tetsuji Niiya, Naoko Kukida, Yasuhiro Inoue, Keizo Ohno, Ikki Shimizu
    2009 Volume 52 Issue 10 Pages 829-835
    Published: October 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.829
    JOURNAL FREE ACCESS
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    Proteinuria is an important risk factor in diabetic nephropathy. Nonproteinuria subjects with type 2 diabetes often develop chronic kidney disease (CKD). To clarify the extent of renal damage in such subjects, we studied risk factors associated with renal function reduction in those with type 2 diabetes with and without microalbuminuria. Subjects numbered 638 with type 2 diabetes -513 with nonalbuminuria and 125 with microalbuminuria. Of these, 67 (13.6%) without albuminuria and 40 (32%) with microalbuminuria had Ccr lower than 60 ml/minute, indicating CKD. Multivariate stepwise linear regression analysis indicated that systolic blood pressure (p=0.00004), body mass index (BMI) (p=0.00010), diabetes duration (p=0.00054), and HbA1c (p=0.02606) were independent risk factors for urinary albumin excretion (UAE) exceeding 30 mg/gCr, while age (p<0.0001), UAE (p=0.00004), and waist circumference (p=0.00055) were independent risk factors for Ccr lower than 60 ml/minute. Risk factors for CKD between type 2 diabetes with microalbuminuria compared to those without proteinuria differed in renal function reduction. We concluded that to prevent kidney disease in diabetic patients, diabetes, hypertension, and obesity should all be managed together. Our results also indicate different etiologies for diabetic nephropathy and CKD.
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