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Volume 42, Issue 8
Displaying 1-10 of 10 articles from this issue
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Keiichiro Ogoshi, Itsuro Nakano, Tetsuhide Ito, Toshihiko Miyahara, Sh ...1999 Volume 42 Issue 8 Pages 651-656
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe investigated pancreatic endocrine function, exocrine function and insulin resistance in 9 subjects with chronic calcifying pancreatitis (CCP).
Insulin and glucagon secretory function were reduced in most of the patients, and pancreatic exocrine function was disturbed in all 9.
Insulin resistance was evaluated using a euglycemic hyperinsulinemic clamp technique. Most of the patients had marked insulin resistance. The correlation between glucagon secretory function and insulin resistance was statistically significant. The results suggest that the reductions in insulin secretion and insulin resistance were observed in the early stage of impaired glucose tolerance associated with chronic pancreatitis and that the insulin resistance diminished together with the development of A cell dysfunction.View full abstractDownload PDF (1022K) -
Zhi-Wei Man, Tsukasa Hirashima, Shigehito Mori, Kazuya Kawano1999 Volume 42 Issue 8 Pages 657-665
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe relationship between a decrease in triglyceride (TG) accumulation in tissues by caloric restriction and an improvement in diabetes in OLETF rats was studied. The OLETF rats were separated into 2 groups: a) a feeding group and b) a 30% restricted feeding growp through 25 weeks of age. LETO rats were used as controls. The changes in body weight and blood chemical characteristics with age, TG content in tissues and glucose infusion rate (GIR), as well as morphological changes in the liver and pancreatic islets were examined in the 3 groups. The results were as follows: 1) body weight and intra-abdominal fats decreased: The plasma levels of TG, insulin and glucose were reduced ; The TG secretion rate was sighificantly feduced and the post heparin lipolytic activity (PHLA) was increased. 2) The TG contents decreased in the liver, pancreas and muscle. 3) The GIR was improved. 4) TG accumulation was not observed in the liver or pancreatic islets on morphological examination. The results suggest that hypertriglyceridemia may be corrected by inhibiting TG synthesis and accelerating TG decomposition with caloric restriction, and that the insulin resistance was improved by a reduction in TG accumulation in the muscle and liver. The improvement in impaired pancreatic B-cell function was thought to be due to the decrease in TG accumulation in the pancreatic islets.View full abstractDownload PDF (2252K) -
Shoich Tomono, Shoji Kawazu, Toshihiro Utsugi, Norihiro Kato, Tomio Oh ...1999 Volume 42 Issue 8 Pages 667-672
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSMany options for the treatment of diabetes mellitus (DM) became available in the 1990 s. Between 1993-1997, two types of α-glucose inhibitors (α-G I) and the thiazolidinedione (TZD) troglitazone were introduced in Japan. Biguanides (BG) gave been used in Japan for 39 years, however, they have recently been reevaluated following the introduction of the BG metformin in the USA in 1995. Moreover, a new pen-system type of insulin injection (novepen III®) became available in Japan in 1994.
We compared the glycemic control of DM using HbA1c of 246 diabetic patients in 1991 with those of 394 patients in 1997. The mean HbA1c of all patients in 1997 (7.2±1.5%) was significantly lower than those in 1991 (7.9±1.7%)(p<0.001). In 1991, 97.1% of 136 patients treated with oral hypoglycemic agents (OHA) were treated with only sulfonylurea (SU), 2.2% only BG and 0.7% a combination of SU and BG. In 1997, 54.1% of 194 patients treated with OHA were given only SU, 3.6% BG, 2.1%α-G I, 2.1% TZD, and 38.1% a combination of these OHA. THe mean HbAic of OHA-treated patients in 1997 (7.4±1.3%) was significantly lower than that in 1991 (8.6±1.7%)(p<0.001). In 1991, only 6.1% of 82 patients were treated with insulin on combination with OHA, while in 1997, 34.6% of 107 patients were treated by combination therapy. The mean HbAic in 1997 (7.9 ± 1.6%) was significantly lower than that in 1991 (8.6±1.9%)(p<0.01). Thus, glycemic control is being sigmificantly improved using various options available for the treatment of DM.View full abstractDownload PDF (1288K) -
The Influence of LPL Gene Hind III PolymorphismToru Onai, Shuichi Okada, Kihachi Ohshima, Masatomo Mori1999 Volume 42 Issue 8 Pages 673-678
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe aim of this study was to investigate whether Hind III polymorphism of the lipoprotein lipase (LPL) gene influences the effects of simvastatin on glucose metabolism. Seventeen subjects with diabetes were treated with simvastatin for 6 months. All subjects were submitted before and after treatment to a oral glucose tolerance test. RFLP for LPL gene (intron 8) was determined by PCR followed by Hind III digestion. Eleven subjects were (+/+) homozygotes for the presence of the Hind III restriction site and 6 subjects were (+/-) heterozygotes. Whereas the incremental area under the curves (AUC) of plasma glucose and serum insulin were not changed after simvastatin administration in heterozygotes, the AUC of plasma glucose was significantly reduced after the treatment without a change in the AUC of serum insulin in homozygotes. These results suggest the association of RFLP for the LPL gene with the effect of simvastatin on insulin action in diabetic patients.View full abstractDownload PDF (1527K) -
Satomi Shibazaki, Masaki Nagai, Seiryo Takashina1999 Volume 42 Issue 8 Pages 679-683
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThis study was performed on 2, 562 inhabitants (999 male and 1, 563 female subjects) in a rural area in western Hiroshima prefecture who underwent on oral glucose tolerance test in a mass health examination for adult diseases. World Health Organization (WHO) criteria and American Diabetes Association (ADA) criteria on fasting plasma glucose levels were used to classify the individuals. The observed prevalences using the ADA criteria were 4.3% in males and 2.8% in females, and were lower than the prevalences with the WHO criteria (7.8% in males and 5.8% in females). The sensitivity and specificity of the ADA criteria to identify cases diagnosed by the WHO criteria were 40.5% and 99.2%, respectively. The sensitivity classified by obesity was the highest in the moderately obese group (55.3%). It was 36.6% in the normal group and 30.8% in the obese group. When classified by body mass index and age, the sensitivity was low in the elderly subjects (70 years old and older) regardless of the BMI. The results suggest that subjects with glucose intolerance among obese and/or elderly subjects may be excluded or neglected in the diagnosis of diabetes when the ADA criteria are used.View full abstractDownload PDF (938K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 8 Pages 685-688
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]1999 Volume 42 Issue 8 Pages 689-694
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
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Kazuhiro Ichida, Masayo Ko, Takeshi Yoshizaki, Tomoko Yamaguchi, Makot ...1999 Volume 42 Issue 8 Pages 695-698
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 69-year-old man was hospitalized on February 12 1997 camplain of muscular weakness and dysarthria.
He was diagnosed as having diabetes mellitus at age 27 by urine glucose examination. From that time he had been treated with diet control until the age of 53, when he started taking oral hypoglycemic agents.
He visited our hospital at age 61. His therapy was changed to insulin therapy at age 65 and stable diabetic control had been maintained.
Although in August 1996 his laboratory data showed a mild elevation of serum CPK concentration (314 IU/l), there were no significant changes in clinical or physical examinations until the end of 1996. From January 1997, he started to feel muscular weakness in both legs and arms and mild dysarthria. On February 11, he came to out hospital complaining of oliguria and severe muscle weakness. At that time, his laboratory data showed severe hyponatremia and high serum CPK concentration. He was admitted the next day for further evaluation.
After admission he was found to have primary hypothyroidism. His severe hyponatremia and high CPK level and muscle weakness recovered gradually after sodium and thyroid hormone replacement therapy.View full abstractDownload PDF (786K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1999 Volume 42 Issue 8 Pages 699-705
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
1999 Volume 42 Issue 8 Pages 707-724
Published: August 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (4724K)
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