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Volume 46, Issue 1
Displaying 1-10 of 10 articles from this issue
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Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Seibei Mi ...2003 Volume 46 Issue 1 Pages 1-5
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSHigh-sensitivity C-reactive protein (hs-CRP) was recently identified as an independent predictor of atherosclerotic vascular disease. The physiological significance of elevated hs-CRP remains to be evaluated, however. To determine the relationship between hs-CRP and insulin resistance and serum E-selectin, an endothelial activation marker, we conducted a case-control study of 45 diabetic patients with high hs-CRP (≥ 0.10 mg/dl) and 45 age-and gender-matched diabetic patients with low hs-CRP (≤0.03 mg/dl). Patients with high hs-CRP had a significantly greater body mass index and triglycerides, and significantly lower HDL cholesterol. Insulin sensitivity, measured by the K index of the insulin tolerance test (Kitt), was significantly lower in patients with high hs-CRP than in those with low hs-CRP (2.29 ± 0.88 vs. 2.82 ± 1.11%/min, mean ± SD, p<0.05). The mean soluble adhesion molecule, E-selectin, was significantly higher in patients with high hs-CRP than in those with low hs-CRP (70.9 ± 29.8 vs. 55.4 ± 30.8 ng/ml, p<0.01). Our results indicate that elevated hs-CRP in patients with type 2 diabetes reflect the presence of insulin resis tance and endothelial activation.View full abstractDownload PDF (670K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2003 Volume 46 Issue 1 Pages 7-10
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]2003 Volume 46 Issue 1 Pages 11-14
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
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Kazuhisa Tsukamoto, Yuji Morisawa, Masashi Fukayama, Kazuyuki Tobe, Te ...2003 Volume 46 Issue 1 Pages 15-22
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 59-year-old male with a 2-year history of diabetes mellitus and a half-year history of hematuria, night sweats, and back pain was admitted for glycemic control and to evaluate bilateral renal tumors.Laboratory data showed rising inflammatory markers and increased HbAic of 7.9%. Glycemic control required 37 units of insulin daily preoperatively for the renal tumors, but no medication was required for glycemic control postoperatively.Preoperative plasma interleukin (IL)-6 was 21.2pg/ml and a histological evaluation confirmed IL-6 expression by some of the renal cell carcinomas.Six months later, when glycemic control was satisfactory and plasma IL-6 was normal, a metastatic lesion was noted in the lung and excised.Histological examination showed no IL-6 expression in this metastatic lesion.One year later, however, further lung metastasis was found and glycemic control worsened gradually accompanied by increasing plasma IL-6 along with the expansion and dissemination of lung metastasis.This is, to our knowledge, the first case report demonstrating the possible association of glycemic control and IL-6 production by the tumor cells in renal cell carcinoma.View full abstractDownload PDF (2680K) -
Michiko Hayakawa, Masanori Iwahashi, Junichi Katoh, Toshirou Tanizaki, ...2003 Volume 46 Issue 1 Pages 23-27
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 75-year-old diabetic woman with arterial hypertension admitted for 1.5 hours of pain and coldness in her right forearm was found in arteriography to have a completely occluded radial artery, which was treated with direct injection of a thrombolytic agent into the brachial artery.Signs and symptoms of acute radial artery obstruction disappeared immediately after injection.After 15 days, repeated arteriography failed to show atherosclerotic changes in her right radial artery.Routine electrocardiographic (ECG) monitoring showed no abnormalities except for a pathological Q wave in leads V1-3.Myocardial perfusion scintigraphy showed a septal defect and UCG showed an enlarged left atrium but no abnormal wall motion.Frequent Holter monitoring showed asymptomatic paroxysmal atrial fibrillation (PAf).Increased risk of nonvalvular atrial fibrillation is reported to be associated with a history of coronary disease, hypertension, diabetes and an enlarged left atrium.We concluded that her arterial occlusion was due to PAf.Some 18 months after this episode, her PAf developed into CAf, which caused a cerebral embolism even though she was treated with warfarin.
Because PAf has been reported to carry a risk of thromboembolism, which approaches that of established chronic atrial fibrillation in those with heart disease, we suggest that diabetic patients with many risk factors be given Holter monitoring even if their ECGs are normal.View full abstractDownload PDF (1059K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2003 Volume 46 Issue 1 Pages 29-33
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
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Motoi Sohmiya, Ippei Kanazawa, Junko Tanaka, Kunio Koshimura, Yuzuru K ...2003 Volume 46 Issue 1 Pages 35-39
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 59-year-old man admitted for poor plasma glucose control and further examination of multiple myeloma was diagnosed with type 2 diabetes mellitus 3 years earlier. Despite insulin therapy, his HbA1c fluctuated between 7% and 8%. He also suffered from multiple stage I myeloma, not requiring therapy. Hyperactivity, overeating, and weight loss occurred 4 months after discharge. Thyroid function was normal and other malignant diseases were excluded. Since Hb A1c decreased to 4.8% with weight loss, insulin dosage was reduced to maintain good plasma glucose control. Eventually, insulin was not required to maintuin plasma glucose control. Intrinsic insulin secretion gradually increased. He was diagnosed as manic. Body weight increased from 49 kg to 60 kg after lithium carbonate administration was started. Insulin secretion was then maintained and Hb A1c was well controlled to 5-6% by diet alone. These findings suggest that a manic state and/or abrupt weight loss may improve plasma glucose control in such cases as ours.View full abstractDownload PDF (527K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2003 Volume 46 Issue 1 Pages 41-45
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2003 Volume 46 Issue 1 Pages 47-52
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
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2003 Volume 46 Issue 1 Pages 53-60
Published: January 30, 2003
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (1609K)
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