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Volume 48, Issue 2
Displaying 1-8 of 8 articles from this issue
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Originale Article
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Shinichiro Mine, Yosuke Okada, Ichiro Takagi, Aya Tanaka, Hiroko Mori, ...2005 Volume 48 Issue 2 Pages 89-95
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSPrevious studies have indicated that adiponectin alters insulin sensitivity and is involved in atherosclerosis in patients with diabetes mellitus (DM). We studied the influence of orally administered pioglitazone on the concentration of serum adiponectin and macrophage chemoattractant protein (MCP)-1 concentrations in patients with type 2 DM. Subjects were 26 healthy individuals and 109 diabetic patients (diet therapy 44 ; sulfonylurea (SU) 42 ; SU + pioglitazone 18 ; SU + metfolmine 5). We found that (1) serum adiponectin was significantly higher (p<0.01) in the SU + pioglitazone group than in the SU or SU + metfolmine group ; (2) serum MCP-1 was significantly lower (p<0.05) in the SU + pioglitazone group than in other groups ; (3) high serum adiponectin and low serum MCP-1 in patients on pioglitazone were detected within 12 months of administration ; and (4) serum MCP-1 correlated significantly and negatively with serum adiponectin. The fact that pioglitazone combination therapy reduced MCP-1 concentrations and increased adiponectin concentrations suggests it has a more favorable therapeutic effect on patients with DM, including possible prevention of atherosclerosis, through the control of blood glucose and improvement of vascular disorders.View full abstractDownload PDF (406K)
Case Reports
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O. Ebisui, T. Inoue, J. Mitsuhashi, T. Enomoto, Y. Sako2005 Volume 48 Issue 2 Pages 97-101
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS -
Mariko Inoue, Miho Ajima, Kumiko Hamano, Yasuo Totsuka2005 Volume 48 Issue 2 Pages 103-107
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSWe report the case of a diabetic patient who developed beriberi after being started on a severer protein-restricted diet and diuretic therapy.
A 54-year-old woman with a 14-year history of slowly progressive type 1 diabetes mellitus was admitted to our hospital because of a progressive sensory disturbance in the extremities, muscle pain and weakness, gait disturbance, and peripheral edema. She had started a low-protein diet (50 g/day ; 0.8 g/kg ideal body weight) at age 51. Three months previously, she had been admitted to the nephrology department of our hospital for amoxicillin-induced acute renal failure, and at that time, her protein intake had been further restricted to 30 g/day and furosemide had been started.
Cardiomegaly (C/T ratio ; 53.9%) and a heart murmur were observed in addition to neurological abnormalities, and a subsequent blood examination revealed vitamin B1 deficiency (6.9 ng/ml ; normal range : 28∼56 ng/ml). All of her symptoms resolved after treatment with thiamine hydrochloride (10 mg/day).View full abstractDownload PDF (408K) -
S. Sasaki, T. Inoguchi, R. Ohtsuka, T. Sonta, H. Tsubouchi, N. Sato, T ...2005 Volume 48 Issue 2 Pages 109-114
Published: 2005
Released on J-STAGE: April 11, 2008
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Y. Takeuchi, N. Itoh, Y. Kuroda, K. Yokoyama, T. Matsuyama2005 Volume 48 Issue 2 Pages 115-121
Published: 2005
Released on J-STAGE: April 11, 2008
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Masataka Osaki, Takuya Awata, Koichi Inukai, Yohei Nakashima, Masaki W ...2005 Volume 48 Issue 2 Pages 123-129
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSPrurigo pigmentosa, first reported by Nagashima et al. in 1971, is a rare inflammatory dermatosis of unknown etiology. Lesions are typically pruritic erhythematous papules, superseded by reticular hyperpigmentation, usually symmetrically distributed on the back, neck, and chest. Several hundred cases have been reported, mainly in Japan, and some are associated with diabetes mellitus. We report prurigo pigmentosa in 2 patients with type 1 diabetes with ketosis and high titer of IA-2 antibodies. Two women, aged 28 and 31 years, reported thirst, polyuria, and weight loss, subsequently suffering from prurigo pigmentosa. Laboratory examinations on admission showed ketosis, hyperglycemia, and decreased insulin secretion. IA-2 antibody was positive with high titer in both, although GAD antibody was negative in 1 case. In both cases, pruritic eruption improved after the start of insulin treatment. We suggest that ketosis and IA-2 autoimmunity play a potential role in prurigo pigmentosa pathogenesis.View full abstractDownload PDF (607K) -
Y. Tokuyama, T. Ishizuka, A. Kanatsuka2005 Volume 48 Issue 2 Pages 131-134
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS
Co-medcial
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T. Takei, K. Hiramatsu, H. Mori, K. Fujiwara, K. Nishimura, M. Sakai, ...2005 Volume 48 Issue 2 Pages 135-137
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS
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