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Volume 31, Issue 1
Displaying 1-11 of 11 articles from this issue
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Kazuko Otsuka, Masahiko Yoshida, Hikaru Koide1988 Volume 31 Issue 1 Pages 1-6
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied clinical factors affecting the progress of diabetic nephropathy.
Sixty-three patienfts were divided among four groups from the viewpoint of nephrotic syndrome (NS) and hemodialysis (HD) in their clinical course.
group 1 with NS and HD
group 2 without NS and with HD
group 3 with NS and without HD
group 4 without NS and HD
The mean years from the diagnosis of diabetic nephropathy to HD were 3.6 ± 2.4 years in group 1 and 7.3±7.3 in group 2 (p<0.05)
The period from the onset of NS and HD were 1.2 ± 0.8 years in group 1. All patients of this group proceeded to HD within three years.
The findings of eyegrounds were more severe in the NS groups than the non-NS groups, while those of patients in group 2 were slight even at the start of HD.
The rate of complication of hypertension was nearly same in all groups.
In conclusion, the presence of NS had an important effect on the progress of diabetic nephropathy.View full abstractDownload PDF (1044K) -
Reiko Okazaki, Kempei Matsuoka, Akira Horiuchi, Katsuya Maruyama, Isao ...1988 Volume 31 Issue 1 Pages 7-13
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum laminin and type III procollagen peptide (P-III-P) in diabetics was measured by radioimmunoassay methods. Results were analyzed with regard to diabetic microangiopathy, diabetic control and duration. Both serum laminin and P-III-P levels increased with development of diabetic retinopathy and proteinuria. Patients with diabetic microangiopathy but with good diabetic control of short duration showed significantly higher values of both serum laminin and serum P-III-P than did those without diabetic microangiopthy but with poor control of long duration. Most of the former patients had been incorrectly treated with hypoglycemic agents in the past. It is suggested that serum laminin and serum P-III-P may play an important role in the development of diabetic microangiopathy. Furthermore, incorrect use of hypoglycemic agents seems to affect connective tissue metabolism in diabetics.View full abstractDownload PDF (1110K) -
Yutaka Mori, Junichi Yokoyama, Masahiko Nishimura, Osamu Serizawa, Yos ...1988 Volume 31 Issue 1 Pages 15-20
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSpontaneously developed diabetes mellitus was observed in aged males of an inbred strain of Wistar rats, WBN/Kob. Non-obese male WBN/Kob rats developed glycosuria and hyperglycemia at about 6 months of age. The cumulative incidence of diabetes was 43%(33 out of 76) at 12 months of age and reached 90% at the age of 21 months. Diabetic rats were hypersensitive to exogeneous insulin, but showed no significant decrease in plasma glucose level when treated with oral tolbutamide. Serum levels and urinary excretion of amylase in WBN/Kob rats were significantly higher than those in control Wistar rats.
The pathophysiology of this diabetes mellitus was quite different from that of type I or II diabetes mellitus in man and animals. A new strain of spontaneously developed diabetic rats with exocrine pancreatic insufficiency was established.View full abstractDownload PDF (706K) -
Yutaka Mori, Junichi Yokoyama, Masahiko Nishimura, Osamu Serizawa, Yos ...1988 Volume 31 Issue 1 Pages 21-25
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo investigate the pathophysiology of the spontaneously developed diabetic rat (strain WBN/Kob) with exocrine pancreatic insufficiency, pathological examination of the pancreas was performed at 2 to 3 month intervals. Serial sections of the pancreas were stained with HE and immunostained for insulin and glucagon by the ABC method. At 1 month of age, no abnormal change was observed in the islet or acinar cells. At 3 months inflammatory change and fibrous exudation were observedbut the islet cells were intact. A gradual increase in fibrous tissue was observed at 6 and 9 months. At 12 months, fibrous tissue had invaded an extensive area of the pancreas and involved the islets. The amylase content of the pancreas in WBN/Kob rats was markedly lower than that in normal Wistar rats at the same age. Islets composed of few endocrine cells were detected and immunohistochemical study showed decreased numbers of not only B cells but also A cells.View full abstractDownload PDF (6425K) -
Keiko Taito, Yasue Omori, Satomi Minei, Meimi Shimizu, Keiko Azuma, Ri ...1988 Volume 31 Issue 1 Pages 27-33
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMaternal serum alpha-fetoprotein, (MSAFP) in normal pregnant women has been used to screen for fetal neural tube defect.
We measured MSAFP levels in 57 pregnant diabetic women, throughout pregnancy, to clarify the relationship between MSAFP and fetal abnormality.
The controls were 136 healthy pregnant women. No twins were born in either group.
Average age at delivery in pregnant diabetics was 28.8±4.2 years and average duration of diabetesuntil delivery was 7.0 ± 4.6 years. The pregnant diabetics consisted of 24 women with IDDM and 33 with NIDDM.
Pregnancies resulted in 2 spontaneous abortions, 1 intrauterine death, 9 premature deliveries, and 45 full-term deliveries.
MSAFP levels in the diabetics incresed from 12 to 15 weeks of gestation (mean MSAFP levels in 12 to 15 weeks of gestation: 18.9 ± 10.1 ng/ml), peaking at 32 to 35 weeks, (272.8 ±78.3 ng/ml),
There were no differences in MSAFP levels between diabetics and controls up to 12 weeks or after 20 weeks.
MSAFP levels in the diabetics during 12 to 19 weeks of gestation were significantly lower than in the controls.
We found no relaionship between MSAFP levels in diabetics and fetal abnormalities or mean blood glucose levels throughout regnancy.View full abstractDownload PDF (3002K) -
Shogo Masuta, Tsuneo Nakamichi, Yuuichiro Maeda, Humihiko Hata, Yoshia ...1988 Volume 31 Issue 1 Pages 35-40
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined the novel test developed by Johnson et al, the fructosamine test for clinical application. This test permits the measurement of glycated serum protein by colorimetrically recognizing ketoamine (the Amadori compound) produced nonenzymatically by the condensation of glucose and protein.
The serum fructosamine level was about 0.4 mmol/l higher than that in the plasma. The level of serum fructosamine correlated with the furosine level (p<0.001, r=0.78), and the fasting blood glucose level two weeks before sampling. Diabetics had significantly higher fructosamine levels than the contols. (3.83±0.78 mmol/l vs. 2.56±0.30 mmol/l respectively).
Determining the serum fructosamine level may be a clinically useful, rapid, and technically easy test. It can also indicate the blood glucose control situation two weeks before sampling.View full abstractDownload PDF (935K) -
Takashi Iizuka1988 Volume 31 Issue 1 Pages 41-46
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPlasma lipids, lipoproteins, apolipoproteins and lecithin: cholesterol acyltransferase (LCAT) activity were measured in 89 diabetic patients (53 males and 36 females) on insulin treatment in addition to diet control and exercise before and after admission.
The following results compared to the pre-admission were obtained at the time of discharge:
(1) Body weight, fasting blood glucose, triglyceride, total cholesterol, apolipoproteins (A-I, A-II, B, C-II, E) and insulin levels were significantly decreased.
(2) The apolipoprotein A-I/A-II ratio was significantly increased from 4.8 to 5.1 (P<0.001)
(3) The plasma level of HDL 2-cholesterol was not changed: however HDL 3-cholesterol was significantly decreased, resulting in a significant increase in the HDL 2-cholesterl/HDL 3-cholesterol ratio (P<0.001)
(4) HDL 2-triglyceride and HDL 3-triglyceride levels were not changed.
(5) LCAT activity was significantly decreased from 790 to 637 (nmoles/ml·hour)(P<0.05)
In conclusion, improvement of diabetic control in insulin-treated diabetics during hospitalization resulted in a significant change in the composition of HDL as well as LCAT activity, of which the patterns are atherogenic in lipoprotein metabolism.View full abstractDownload PDF (851K) -
Keiichiro Tanigawa, Shinya Note, Kohkichi Hata, Manabu Kitao1988 Volume 31 Issue 1 Pages 47-51
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe have shown previously that infants with single umbilical arteries (SUA) have various cardiovascular malformations with fatal outcomes. We recently experienced another infant with SUA, which was diagnosed antenatally by ultrasonography.
The mother was obese and had a history of glucosuria during pregnancy. A 75 g oral glucose tolerance test (OGTT) at 12 weeks of gestation revealed gestational diabetes. She did not maintain diet therapy. At 35 weeks of gestation, SUA was diagnosed by ultrasonography. The mother was admitted to our hospital and a 75-g OGTT showed a diabetic pattern. Since her body weight was over 45% obese, a 1, 200 kcal diet was initiated. Dialy profiles showed almost normal levels of blood glucose and slightly higher levels of ketone bodies. It was noteworthy that the ketone bodies increased after meals.
She gave birth one month earlier than expectd. The infant had no complications or malformations. SUA was confirmed by macroscopic and microscopic findings. An OGTT repeated one month post partum indicated that the mother had diabetes.
This case suggests that antenatal diagnosis of infants of mothers with gestational diabetes is necessary, and that obese pregnant women must be carefully followed during and after pregnancy.View full abstractDownload PDF (2118K) -
Yoshikuni Fujita, Hirofumi Shigei, Yayoi Nonomura, Akira Kanamori, Kiy ...1988 Volume 31 Issue 1 Pages 53-60
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA woman diagnosed as having insulinoma had a partial pancreatectomy at the age of 71 in 1973. One year later, she began to have hypoglycemia. At the age of 79, she went into a hypoglycemic coma and the I/G ratio of IRI (μU/ml) to glucose (mg/dl) was 3.0. Celiac angiography revealed multiple small masses in the liver. The diagnosis was insulinoma metastasizing to the liver. She was treated with 75 mg of diazoxide (DAX) per day. As a result her hypoglycemia was controlled. The I/G ratio was 0.2. At the age of 83, she became febrile and was not able to take DAX regularly. We expected her to remain hypoglycemic, but instead she became hyperglycemic. Subsequently, she went into a nonketotic hyperosmolar coma (NKHC) and shock. At autopsy, the liver showed numerous localized fatty areas measuring 1-2 cm in diameter. In the center of these localized fatty areas there were insulin-producing cell tumors up to 5 mm in diameter. The remaining pancreas was normal. It was concluded that insulin-producing lesions in the liver were the cause of the hypoglycemia. Although DAX could have been a causative factor of her NKHC, it was effective for controlling hypoglycemia for almost three years. This is the first report of localized fatty changes in the liver due to insulinoma metastasized to the liver.View full abstractDownload PDF (7786K) -
Yutaka Mori, Masahiko Nishimura, Osamu Serizawa, Hideaki Kurata, Junic ...1988 Volume 31 Issue 1 Pages 61-64
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNonobese dibetic (NOD) mice aged 10 weeks were intravenously treated with choleratoxin at a dose of 1.0 μg every two weeks until 24 weeks of age. At the age of 25 weeks, diabetes developed in 13 of 18 saline-treated control NOD mice. These mice showed partial or complete destruction of islets of Langerhans associated with marked lymphocytic infiltration. In contrast, diabetes was observed in 4 of 16 choleratoxin-treated NOD mice and the pancreatic islets showed only mild insulitis. Moreover, two-color flow cytometry analysis of T-cell subsets in peripheral blood revealed significant decreases in the percent of L3T4+ cells and Lyt 2+ cells in choleratoxin-treated NOD mice compared with saline-treated control NOD mice.
These results clearly indicate that choleratoxin prevents diabetes mellitus in NOD mice by inhibiting the development of insulitis by interfering with T-cell proliferation.View full abstractDownload PDF (3213K) -
1988 Volume 31 Issue 1 Pages 65-83
Published: January 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3197K)
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