Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 52, Issue 7
Displaying 1-14 of 14 articles from this issue
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The Theory and Practice of Behavioral Medicine in Diabetic Patients
Original Article
  • Development of the Japanese Version of the Diabetes Medication Satisfaction Questionnaire (Diab-MedSat)
    Hitoshi Ishii, Yujin Shuto, Sakura Okuyama
    2009 Volume 52 Issue 7 Pages 527-535
    Published: July 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.527
    JOURNAL FREE ACCESS
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    We translated the Diabetes Medication Satisfaction Questionnaire (Diab-MedSat) into Japanese and assessed Japanese version reliability and validity. Translation followed standard linguistic validation of forward translation, back translation, and pilot test for patients. Pilot test results for a small number of patients showed no difficulty in understanding the translated questionnaire. For psychometric assessment, statistical analysis was done using questionnaires answered by 208 patients with type 2 diabetes. To assess internal consistency, the Cronbach alpha coefficient ranged from 0.65 to 0.89. For Known-Group validity, scores were associated with the overall satisfaction with diabetes medication. For construct validity, the subscale structure was found to differ from the original questionnaire, but could be considered rooughly the same. The Japanese version of the Diab-MedSat was thus validated both linguistically and psychometrically.
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  • Features and Clinical Implications of Fasting Intact Proinsulin to Insulin Molar (P/I) Ratio 1: P/I Ratio vs Pancreatic β Cell Function in Type 2 Diabetes Mellitus and Reference Range in Subjects with Normal Glucose Tolerance
    Shoji Kawazu, Masako Yazawa, Yasuo Imai, Hitoshi Horie, Yoshikazu Hisa ...
    2009 Volume 52 Issue 7 Pages 537-545
    Published: July 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.537
    JOURNAL FREE ACCESS
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    Using an Intact-Proinsulin Assay® (MLT Research Ltd.), we studied the clinical implications and usefulness of the plasma intact proinsulin to insulin molar ratio (P/I) ratio in morning fasting. Obese (BMI≥25 kg/m2) adults (age≥30 years old) with normal glucose tolerance (NGT) had a significantly lower P/I ratio than nonobese adults with NGT. The P/I ratio reference range in nonobese adult NGT was 0.04-0.31. In nonobese subjects with differing degrees of glucose tolerance, the P/I ratio increased significantly with glucose intolerance severity. The P/I ratio in subjects with type 2 diabetes mellitus treated with diet and exercise alone whose fasting glucose exceeded 126 mg/dl was significantly higher than in those whose fasting glucose was less than 126 mg/dl. The P/I ratio correlated significant by inverse by with the insulinogenic index in the 75 g oral glucose tolerance test. We found that the P/I ratio is closely related to insulin secretory ability, and may be a simple, easy index for reflecting the impoverishment or functional decline in pancreatic β cells.
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  • Features and Clinical Implications of Fasting Intact Proinsulin to Insulin Molar (P/I) Ratio 2: Analysis on the Correlation Between P/I Ratio and Each Factor in the Type 2 Diabetes Mellitus
    Shoji Kawazu, Masako Yazawa, Yasuo Imai, Hitoshi Horie, Yoshikazu Hisa ...
    2009 Volume 52 Issue 7 Pages 547-554
    Published: July 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.547
    JOURNAL FREE ACCESS
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    We examined the characteristics of plasma intact proinsulin to insulin molar (P/I) ratio at fasting in the morning, using type 2 diabetic patients. P/I ratio showed a significant correlation with HOMA-β and Insulinogenic Index. In multivariate analysis, fasting plasma insulin was well associated with BMI, and intact proinsulin was associated with BMI and fasting plasma glucose. On the other hand, P/I ratio was associated with duration of diabetes in addition to the above. P/I ratio of the patients who were positive for family history showed significantly higher value than the non-family history group. Moreover, P/I ratio of the patients with diabetic complications showed significantly higher value than the non-complication group. Furthermore, P/I ratio of glibenclamide or glimepiride group, were significantly higher than that of the diet group. These results suggest that P/I ratio could be useful to understand pancreatic β cell dysfunction in type 2 diabetes mellitus, either for estimating the stage of diabetes or titrating the optimal drug therapy.
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