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Volume 43, Issue 5
Displaying 1-10 of 10 articles from this issue
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Michiyo Takayama, Ken Shinmura, Hiroshi Hasegawa, Masato Tani, Toshiko ...2000 Volume 43 Issue 5 Pages 347-354
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe performed two studies to investigate the clinical roles of VEGF and HGF in diabetes mellitus.(1) Serum concentrations of VEGF and HGF were measured in type-2diabetic patients (DM, n=74) and control subjects (C, n=44) by enzyme-linked immunosorbent assay, and their relationship to fasting plasma glucose (FPG), hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), liver function, systolic blood pressure, smoking, and diabetic angiopathy were analyzed.(2) VEGF and HGF concentrations were measured in both the serum and anterior aqueous humor of type-2diabetic patients (n=33) and nondiabetic patients (n=12) who underwent eye surgery, and their correlations with diabetic retinopathy were determined.(1) There were no differences in serum VEGF between C and DM, but, serum VEGF was significantly higher in DM with diabetic angiopathy. Serum HGF was higher in DM and smokers, and inversely correlated with HDL-C and FPG.(2) Neither serum VEGF nor HGF were associated with retinopathy, but anterior aqueous humor VEGF was extremely higher and HGF tended to be higher in DM with preproliferative diabetic retinopathy. VEGF and HGF were not correlated in serum, but a positive correlation was observed in anterior aqueous humor. These results suggest that VEGF and HGF affect diabetic retinopathy, however, no relationship to diabetic macroangiopathy could be detected.View full abstractDownload PDF (1630K) -
Mayumi Morimoto, Michitoshi Doi, Seijiro Tsutsumi, Ichiro Yokota, Kenj ...2000 Volume 43 Issue 5 Pages 355-360
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA highly sensitive IRMA for serum C-peptide (CPR), whose sensitivity was 0.01ng/ml and 10 times higher than that of the commercially available RIA kit (RIA kit), was developed. serum CPR was undetectable by the IRMA in27of52juvenile type-1diabetics. This may reflect the clinical reflect the clinical characteristics of type-1diabetes, i, e., that secretion of insulin is often suppressed. CPR was undetectable by the IRMA in serum treated with charcoal and serum from patients who had undergone total pancreatectomy but values of 0.17-0.23ng/ml were determmed with the RIA kit (RIA kit, Shionogi, Osaka, Japan). In a dilution test of two patients' sera diluted with CPR-free serum and the serum of a patient who had undergone total pancreatectomy, linearity of the dilution line from point 0 was observed with the IRMA but not RIA kit. Thus, the lower serum CPR values obtained by the IRMA might be more reliable than those obtained with the RIA kit. A good correlation was obtained between the semlm glucose values and CPR values measured by the IRMA and RIA kit, although the CPR values obtained with the IRMA were lower than those obtained with the RIA kit. Serum CPR values in juvenile type-1diabetics measured by the IRMA were well correlated with those determined with the commercial RIA kit, although CPR vahles by the former were lower than those obtained with the latter.View full abstractDownload PDF (842K) -
[in Japanese], [in Japanese], [in Japanese]2000 Volume 43 Issue 5 Pages 363-366
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
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Noriko Takebe, Kiyoshi Fujimaru, Kiyoshi Matsubara, Haruhito Taneichi, ...2000 Volume 43 Issue 5 Pages 367-371
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 69-year-old woman with SPIDDM (slowly progressive insulin-dependent diabetes mellitus) associated with pernicious anemia is reported. Her onset of diabetes mellitus was at the age of 65 years. After treatment with oral hypoglycemic agents for 5 years, insulin therapy was initiated. She had complained of general fatigue and headache for the last 2 years. Laboratory findings showed severe macrocytic hypochromic anemia, low concentrations of serum VB12, and antibodies against intrinsic factor and parietal cells. The serum C-peptide level was low even after a glucagon loading test. Anti-islet cell antibodies were negative, but antibodies to glutamic acid decarboxylase were positive. Furthermore, anti-thyroglobulin antibodies and anti-thyroperoxidase antibodies were also positive. She had B 54 (22) and DR 4 of HLA. Her anemia was improved by parenteral treatment with hydroxocobalamine. These findings indicate that the patient had pernicious anemia, SPIDDM, and chronic thyroiditis. Autoimmune mechanisms are thought to play essential roles in the development of these three diseases. Only 11cases of diabetes mellitus associated with pernicious anemia have been reported in Japan.View full abstractDownload PDF (849K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2000 Volume 43 Issue 5 Pages 373-377
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
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Hideo Nunome, Masanobu Takeda, Akiko Sato, Tomoko Nakagami, Naoko Iwas ...2000 Volume 43 Issue 5 Pages 379-384
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSPyomyositis is an infection of skeletal muscles, that occurs frequently in tropical areas, tropical pyomyositis, however it is uncommon in Japan.
Case 1: A 45-year-old man with Type 2 Diabetes was admitted because of severe pain, swelling and hotness in his right lower extremity. He had undergone puncture of the right knee joint three times before admission. A CT scan of his right lower extremity demonstrated a low-density area with gas production in the muscles. After a needle aspiration of the right femoral muscles and right knee joint, a diagnosis of pyomyositis and septic arthritis was determined. Incision and drainage were performed on hospital day 17, which significantly improved his outcome.
Case 2: A 31-year old man with Type 2 Diabetes was admitted because of swelling and hotness in his left lower extremity after skin ulceration due to a scalding injury before admission. Radiography demonstrated gas production, and a large amount of fluid collection was revealed on an ultrasonography. Under the diagnosis of pyomyositis, incision of the left lower leg was performed on hospital day 47, which significantly improved his outcome.
Pyomyositis should be taken into account as one of a differential diagnosis when a diabetic patient presents with swelling, pain and hotness of muscles. Moreover, CT scan and ultrasonography are useful for diagnosis of pyomyositis.View full abstractDownload PDF (1895K) -
Shinichi Teno, Tetsuya Babazono, Kozo Katsumori, Naoko Iwasaki, Makoto ...2000 Volume 43 Issue 5 Pages 387-391
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSPrurigo pigmentosa is an inflammatory dermatosis that was first described by Nagashima et al. in 1971. The lesions are characterized by recurrent pruritic erythematous papules that resolve leaving a peculiar, reticulate hyperpigmentation. The cause of prurigo pigmentosa is unknown, however, some cases with prurigo pigmentosa have been reported to be related to ketosis. We report here three patients with PP that were seen during the onset of diabetes mellitus with diabetic ketosis. These males aged 15, 12 and 41years complained of thirst, polyurea and weight loss. From the laboratory examinations on their admission revealing ketosis (ketoacidosis in the seccond patient), hyperglycemia and decreased insulin secretion, they were diagnosed as having newly onset-diabetes. They had HLA-DR 4. During the onset period, prurigo pigmentosa was found on the right shoulder, the neck and back and the upper abdomen of the respective patients. In all the patients, pruritic eruption improved after intensive insulin treatment and only patient 3 was treated with minocycline. We suggest that ketosis caused by newly onset-diabetes and HLA-DR 4 may play a potential role in the pathogenesis of prurigo pigmentosa.View full abstractDownload PDF (1495K) -
[in Japanese], [in Japanese], [in Japanese]2000 Volume 43 Issue 5 Pages 393-396
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
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Keiichi Kodama, Akira Shimada, Akira Kasuga, Manabu Nakashita, Ryuji S ...2000 Volume 43 Issue 5 Pages 397-402
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 78-year-old man was diagnosed as having diabetes mellitus and Idiopathic Thrombocytopenic Purpura (ITP) in 1988. He was started on 5mg of prednisolone daily in 1993. His blood sugar level gradually increased to 1994, and therefore he was admitted to our hospital and insulin therapy was started in 1997. During the admission period, he was found to have anti-GAD and JA-2 antibodies indicating that he was suffered from type 1 diabetes. We report this case because the occurence of type 1 diabetes with ITP is considered to be relatively rare.View full abstractDownload PDF (1131K) -
2000 Volume 43 Issue 5 Pages 405-419
Published: May 30, 2000
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (4872K)
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