Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 65, Issue 9
Displaying 1-9 of 9 articles from this issue
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Feature
Optimal Care for Diabetes in Older People
Original Article
Pathophysiology, Metabolic Abnormalities, Complications
  • A Survey of Sleep Condition in Japanese Patients with Diabetes
    Yuji Tajiri, Yuka Goto, Yuko Matsuo, Yui Nakamura, Yoshie Otsuka, Moek ...
    2022 Volume 65 Issue 9 Pages 497-504
    Published: September 30, 2022
    Released on J-STAGE: September 30, 2022
    DOIhttps://doi.org/10.11213/tonyobyo.65.497
    JOURNAL FREE ACCESS
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    A bidirectional relationship between sleep disturbance and diabetes mellitus (DM) has been reported. This cross-sectional study analyzed 209 outpatients with DM who visited our hospital between January 2017 and December 2018. We investigated the sleep condition by a questionnaire using the 3-Dimensional Sleep Scale (3DSS). Sleep quality in DM patients was significantly lower than that in healthy subjects. A multivariate analysis was performed which included the results of each item in the 3DSS as outcome variables in DM patients. Sleep phase was positively correlated with patient's age, and was advanced among elderly patients. Sleep quality proved to be markedly low in patients complaining of nocturia and users of hypnotic agents, and was significantly low in patients with leg cramps and female patients. Sleep quantity was inversely corelated with HbA1c, and was significantly low in patients with leg cramps and female patents. Sleep disturbance in DM patients was evident in the present observational study, and multi-dimensional approaches including treatment to alleviate neuropathy or urological intervention seem to be warranted.

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Case Report
  • A Case of Variant Hemoglobin Hb Hoshida [β43 Glu (GAG) →Gln (CAG) ] Diagnosed at the Onset of Acute-onset Type 1 Diabetes Mellitus
    Yoshiko Nakagawa-Nagahama, Masaki Igarashi, Masaomi Miura, Takayoshi S ...
    2022 Volume 65 Issue 9 Pages 505-511
    Published: September 30, 2022
    Released on J-STAGE: September 30, 2022
    DOIhttps://doi.org/10.11213/tonyobyo.65.505
    JOURNAL FREE ACCESS
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    We experienced a case of variant hemoglobin that was discovered after the onset of acute-onset type 1 diabetes mellitus. In this case, HbA1c was able to be properly measured by the enzymatic method, but extremely low values of HbA1c and an abnormal peak that was likely caused by variant hemoglobin were observed on high-performance liquid chromatography. The variant hemoglobin was identified as Hb Hoshida [β43 Glu (GAG) →Gln (CAG) ]. Hb Hoshida is a genetic abnormality of the hemoglobin beta chain that was first reported by Iuchi et al. from Japan in 1978 and has since been reported in several cases associated with diabetes mellitus. In cases with type 1 diabetes mellitus, the existence of variant hemoglobin may cause difficulty in differentiating between acute-onset type 1 diabetes mellitus and fulminant type 1 diabetes mellitus, which requires special attention. In the outpatient setting, glycated albumin, intermittently scanned continuous glucose monitoring and continuous glucose monitoring may be useful for glycemic control.

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