Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Search
Advanced search
OR
Browse
Search
Volume 52, Issue 1
Displaying 1-10 of 10 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Original Article
  • Clinical Effects of Metformin in Patients with Nonobese Type 2 Diabetes
    Kazuhiro Hosokawa, Shu Meguro, Osamu Funae, Chisato Murata, Kiyoe Kato ...
    2009 Volume 52 Issue 1 Pages 1-6
    Published: January 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.1
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Metformin is indicated for obese insulin-resistant type 2 diabetic patients but also acts clinically in nonobese patients.
    We retrospectively studied 275 patients—172 men and 103 women undrergoing 1-year metformin monotherapy as outpatient at Saiseikai Central Hospital, Tokyo. Based on BMI, we divided them into Group 1 with a BMI of 22 or less, Group 2 with 22.1-24.9, and Group 3 with 25 and over. By group, baseline age was 60.1±9.8 years old for 1, 59.8±8.6 for 2, and 55.8±11.9 for 3. Diabetes duration was 13.0±7.2 years for Group 1, 11.1±7.3 for Group 2, and 8.7±6.3 for Group 3. Group 1 baseline HbA1c was 8.07±0.71%, 8.15±0.96% for Group 2, and 8.16±1.28% for Group 3. Six months after metformin monotreatment alone, HbA1c had decreased by -0.79±0.88% in Group 1, -0.81±1.0% in Group 2, and -0.73±1.06 % in Group 3, with no significant difference.
    Patient age Group 3 overall was somewhat younger and diabetes duration shorter, but the HbA1c reduction from baseline to six months was similar in all groups.
    In summary, the metformin effect in nonobese patients was equally effective as in obese patients.
    View full abstract
    Download PDF (370K)
  • Blood Glucose Stabilization by Predinner Insulin Glargine in Intensive Therapy with Rapid-Acting Insulin Analog
    Hitomi Nakayama, Tomoko Kato, Hiroo Kaku, Fumi Niizeki, Tokunori Mukai ...
    2009 Volume 52 Issue 1 Pages 7-11
    Published: January 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.7
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To compare the effects of NPH insulin at bedtime and insulin glargine before dinner combined with premeal rapid-acting-insulin analog injections, we assessed daily plasma glucose profiles in 177 inpatients with Type 1 (n=61) or Type 2 (n=116) diabetes. We found no significant difference in doses of either rapid-acting-insulin analog or NPH/glargine, but Type 2 diabetes patients showed significantly lower post breakfast and post dinner glucose when injected with insulin glargine. Type 1 diabetes patients showed bedtime NPH associated with an elevated low blood glucose index at 03:00. Predinner glargine significantly reduced nocturnal hypoglycemic risk. These observations showed that predinner glargine combinated with rapid-acting-insulin analog acts more beneficially on postprandial hyperglycemia in Type 2 diabetes and nocturnal hypoglycemic risk in Type 1 diabetes than bedtime NPH in equivalent doses.
    View full abstract
    Download PDF (332K)
  • Prevalence and Psychological Aspects of Eating Disorder and Abnormal Eating Habits in Type 1 Diabetes Patients
    Sachie Tsukahara, Yasuko Uchigata, Kouichi Ishido, Masato Takii, Yasuh ...
    2009 Volume 52 Issue 1 Pages 13-21
    Published: January 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.13
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To clarify the prevalence of eating disorders (ED), i.e., anorexia nervosa, bulimia nervosa, and binge eating; abnormal eating habits (AEH); and others (others), we studied the clinical records of 96 hospitalized type 1 diabetes patients (31 men and 65 women from 20 to 40 years old) using five psychological tests, i.e., eating disorder eating disorder inventory (EDI), Zung self-rating depression scale (SDS), state-trait anxiety inventory (STAI), problem areas in diabetes surrey (PAID) and multi-dimensional perfectionism scale (MPS), and structured interviews. ED at 13.5% and AEH at 26.0% predominated and were more frequent in women, who also showed higher subscale scores for “penchant for thinness” and “body dissatisfaction”. Diabetic retinopathy and nephropathy were more frequent in ED patients than in the other two groups. “Perfectionism” and “ineffectiveness” on the EDI subscale and “parental expectations” on the MPS subscale were related to diabetic microangiopathy. About 10% of patients in the other group also had proliferative retinopathy and nephropathy. And their total scores for EDI, MPS, and other subscales were low, suggested effects of diabetes complications on their psychological background. These results suggest that early ED and AEH diagnosis is important in preventing diabetic complications in type 1 diabetes patients.
    View full abstract
    Download PDF (317K)
Case Report
Co-medical
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top