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Volume 38, Issue 2
Displaying 1-10 of 10 articles from this issue
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[in Japanese]1995 Volume 38 Issue 2 Pages 83-89
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
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[in Japanese]1995 Volume 38 Issue 2 Pages 91-93
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
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[in Japanese]1995 Volume 38 Issue 2 Pages 95-97
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
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Fukashi Ishibashi1995 Volume 38 Issue 2 Pages 99-104
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSBlood pressure, urinary NO (assessed by NO2-/NO3-, stable metabolite of NO) and cGMP were monitored for one hour before and during L-arginine infusion (LA) in 20 patients with NIDDM and 20 healthy controls.
LA induced hypotension immediately after infusion, with the minimum blood pressure values occurring at the end of the infusion. The hypotension induced by LA was attenuated in NIDDM (SBP: 126.4±3.0→112.3±2.8mm Hg, DBP: 79.8±2.9→68.2±2.8mm Hg) compared with the controls (SBP: 123.8±1.4→104.6±1.8, DBP: 76.3±2.8→62.3±2.2mm Hg). Urinary NO values before and during LA were inversely correlated with systolic and diastolic blood pressure both in the controls and in NIDDM (p<0.05 or p<0.01). NO values before and during LA in NIDDM (22.4±2.7→26.7±2.5μmol/gCr/hr) were higher than the controls (15.8±1.4→19.2±1.6μmol/gCr/hr). There were no differences between the two groups in urinary cGMP before (440.8±25.4 vs 423.6±47.1μmol/gCr/hr) or during (582.8±55.2 vs 569.5±44.2μmol/gCr/hr) LA. Urinary NO and cGMP were significantly correlated before (p<0.005) and during (p<0.001) LA in the control subjcts, but not in NIDDM.
These results indicate that LA-induced hypotension in NIDDM is attenuated probably due to impaired generation of cGMP by NO.View full abstractDownload PDF (779K) -
Toshihiro Kawabata, Hideki Hidaka, Hideto Kojima, Yukio Shigeta1995 Volume 38 Issue 2 Pages 105-112
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effects of high-density lipoproteins (HDL) on the accumulation and efflux of cholesterol were studied in J774 macrophage cells cultured at a high glucose concentration to investigate whether a high level of glucose changes cell functions in relation to the high incidence of atherosclerosis in diabetes mellitus. 14C-oleate incorporation rates into cholesterol ester in the presence of acetyl LDL increased 2.1-fold in cells cultured at 33 mM glucose for 10 days (HG cells) compared with those in 11 mM glucose (NG cells). The incorporation rates were decreased by HDL dose-dependently and reached 21.8%±3.4% of the basal value with 200μg/ml HDL in the NG cells, but the suppressive effects of HDL were reduced in the HG cells (56.0±3.4% of basal, p<0.01), where the effects in osmolarity-adjusted cells with mannitol were not altered compared with those in NG cells. HDL-induced efflux of cholesterol from the cells preincubated with 14C cholesterol-labeled acetyl DLL was also decreased in HG cells (11.0±0.1% vs. 9.8±0.1%, p<0.05). Acyl Co-A: cholesterol acyltransferase (ACAT) activity was increased 1.7-fold in the HG cells, but acid and neutral esterase activities as well as 125I HDL binding were not changed, suggesting that the mechanisms of deterioration in HDL action in HG cells are accounted for not by the alteration of HDL receptors, but by intracellular abnormalities induced by culture under a high glucose concentration.
These results indicate that culture under high glucose levels changes the functions of cholesterol accumulation and efflux in the J774 macrophage cell line, inducing foam cell formation, and suggest that poor glycemic control may contribute to the development of atherosclerosis not only by the glycation of lipoproteins and/or extracellular matrix but also by altered cellular function in macrophages in diabetes mellitus.View full abstractDownload PDF (1185K) -
Tatsuhiko Urakami, Hiroko Matsunaga, Yukinobu Miyamoto, Misao Owada, T ...1995 Volume 38 Issue 2 Pages 113-118
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSSerial changes in the prevalence of islet cell antibodies (ICA) and ICA titers over the ten years follwing diagnosis were studied in 34 children with insulin-dependent diabetes mellitus (IDDM), 17 with abrupt onset and 17 with slow onset, whose duration of disease was more than five years.
There was a high prevalence of ICA in both forms of IDDM at the time of diagnosis (abrupt onset 94%, slow onset 82%). However, the decline in the frequency of ICA in slow onset patients was less marked than that in abrupt onset patients after a duration of one year om more (47 vs 82%; 1-3 years, 24 vs 47%; 3-5 years, 24 vs 47%; 5-7 years, 18 vs 53%; 7-10 years, p<0.05). Concerning the changes in ICA titer, abrupt onset patients initially had high ICA levels (160-320 Juvenile Diabetes Foundaton; JDF units), but ICA titers decreased rapidly with time. On the other hand, soiw onset patients tended to show low ICA titers for a long period after diagnosis (20-40 JDF units).
From these results, it is possible that the change in ICA titer reflects the slow autoimmune destruction of pancreatic β-cells and slow onset IDDM is characterized by relatively mild progression in the early phase of the disease.View full abstractDownload PDF (904K) -
Study Using Minimal ModelJunji Hirayama, Hiroki Jiko, Mihoko Ihozaki, Tomomi Shiotani, Tokunori ...1995 Volume 38 Issue 2 Pages 119-124
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effects of an angiotensin converting enzyme inhibitor (alacepril) on insulin sensitivity were studied in patients with NIDDM associated with hypertension. Insulin sensitivity (SI) and glucose effectiveness (SG) were calculated by frequently sampling intravenous glucose tolerance test (Minimal Model Procedure). SI in hypertensive patients (1.5±0.210-4/min·(μU/ml), n=13) was significantly (p<0.05) lower than that in normotensive patients (2.8±0.510-4/min·(μU/ml), n=12).Alacepril administration (50mg/day, p.o., for4weeks) toulltreated hyperte nsivepatiellts (n=7) significantly lowered their blood pressure levels and significantly improved the reduced SI of 1, 5±0.410-4/min·(μU/ml) to 2.0±0.5 (p<0.05), not changing significantly the SG.
These results indicate that alacepril is a beneficial medicine for the treatment of NIDDM patients associated with hypertension.View full abstractDownload PDF (781K) -
Yasuo Kida, Atsunori Kashiwagi, Hiroko Nakagawa, Ryuichi Kikkawa, Yuki ...1995 Volume 38 Issue 2 Pages 125-131
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSVentricular late potential (LP) has been reported as a useful marker for sudden death due to ventricular arrhythmias. Our previous data indicated that sudden death was more frequent in diabetics than in the general population. Reducing the cause of sudden death is important in improving the life prognosis of diabetics. In the present study, the frequency of LP in 68 non-diabetic controls (group C) and 308 diabetics (group DM) was determined. Furthermore, clinical characteristics, ventricular arrhythmias and the life prognosis of diabetics with LP were also investigated. 1) The Frequency of LP was similar in groups C and DM (4.3% vs 4.9%). 2) No significant correlation was observed between LP and glycemic control, duration of DM, or diabetic complications in group DM. 3) Diabetics with LP tended to have a higher frequency of ventricular tachycardia, but no malignant arrhythmia was observed in many cases of LP. 4) During 2 years of follow-up, although 33% of diabetics with LP died, the association of LP with sudden death was not clear.View full abstractDownload PDF (1132K) -
Michiko Zen-nyoji, Kei Sato, Hiroyuki Shimizu, Noriyuki Sato, Masatomo ...1995 Volume 38 Issue 2 Pages 133-137
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe combination of diabetes mellitus is frequent in families of patients with multiple sclerosis (MS) in Europe and North America, but not in Japan. We report a 39-year-old woman who suffered from non-insulin dependent diabetes mellitus (NIDDM) with MS. She was diagnosed with NIDDM when she was pregnant at the age of 25. Oral hypoglycemic agent (OHA) therapy was started after the spontaneous abortion, but she stopped OHA therapy by herself. At the age of 32 years, insulin therapy was begun following the onset of retinal bleeding. At the age of 36 years, she felt numbness in the lower extremities. Around 3 months prior to admission, gait distrubance and dysarthria appeared. On admission, deep tendon reflex was generally weak and extensor plantar reflex was elicited. She had truncal ataxia, disturbed coordination in the left upper and lower extremities and dysdiadokokinesia. Urinary C-peptide (CPR) excretion was increased by 175μg/dayandserum CPR level responded well to 1 mg of intravenously administered glucagon. On MRI study, multiple low signal intensity (T1) and high signal intensity (T2) lesions were observed in the subcortical area. Since two oligoclonal bands were positive in the cerebrospinal fluid, she was diagnosed as having MS. The present case raises the possibility of the interrelationship between NIDDM and MS.View full abstractDownload PDF (2610K) -
1995 Volume 38 Issue 2 Pages 139-157
Published: February 28, 1995
Released on J-STAGE: March 02, 2011
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