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Volume 38, Issue 7
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Yuan-Qing Zhao, Hajime Himei, Takashi Matsuoka, Yoshiteru Kawanishi1995 Volume 38 Issue 7 Pages 485-490
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA spectral analysis of changes in R-R interval was parformed at rest and during deep breating by the maximum entropy method (MEM) and compared between patients who showed sympathetic skin respones (SSR) omission a low amplitude or no response and normal responses, then SSR was further compared with findings on myocardial scintigraphy (SPECT) using changes in the low-frequency range.
The standard deviation and hinge spread of variation range of R-R interval and values of segmental integration were significantly increased in the high-frequency range after deep breathing, reflecting parasympathetic nerve function. But in the low-frequency range, reflecting sympathetic nerve function, the value of segmental integration had already decreased at rest and no increase after deep breathing was observed on SSR test in patients with impaired autonomic nervous function who showed by myocardial scintigraphy (SPECT) or prolongation of latency and a clear decrease in the amplitude of SSR or no responses.
In power spectral analysis of the variation range of R-R interval recorded with SRR-5 on ECG using MemCalc 1000, the change in the value of segmental integration in the low-frequecy range during deep breathing was considered to be a useful clinical index for the evaluation of sympatheti nerve function in patients with diabetes mellitus.View full abstractDownload PDF (1177K) -
Jun-ichi Hirai, Takanobu Wakasugi, Takashi Saga, Chikashi Kitoh, Taday ...1995 Volume 38 Issue 7 Pages 491-499
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effects of obesity and glucose intolerance on blood pressure and their relation to renal dysfunction have not been fully elucidated. We assessed the influence of body mass index, glucose intolerance, age, and sex on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), serum creatinine (Cr) and proteinuria in 5807 subjects who had received health examinations.
The subjects were divided into 5 groups according to their body mass index: lean, normal lean, normal obesity, overweight, and obesity. They were also divided into 4 groups based on the results of an oral glucose tolerance test: normal (NOR), borderline (BOR), impaired glucose tolerance (IGT), and diabetes mellitus (DM). We then checked the blood pressure and the renal dysfunction of each subgroup. The following results were obtained:
(i) SBP and DBP values were increased beginning in the normal obesity stage.
(ii) SBP, DBP and PP values were increased in the diabetic cases.
(iii) Blood pressure was more influenced by obesity than glucose intolerance or renal dysfunction.
(iv) The blood pressure was influenced arithmetically in men 40 to 59 years old and women 40 to 49 years old, and synergistically in women 50 to 59 years old by theobesity and glucose intolerance.View full abstractDownload PDF (1350K) -
Clinical Features and the Relationship to Serum Type IV Collagen LevelsHiroko Yoshino, Sumiko Hasumi, Yasue Omori1995 Volume 38 Issue 7 Pages 501-507
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSLimited joint mobility (LJM) and Dupuytren's contracture are cutaneous collagen disorders which occur in diabetic patients. 168 cases of NIDDM, with and without cutaneous collagen disorders, were investigated concerning the prevalence and severity of microvascular complications and their relationship to serum type IV collagen levels. Thirty of the patients (17.9%) had LJM and 26 (15.5%) had Dupuytren's contracture. HbA1c was significantly higher in the patients with LJM than in the patients without LJM (p<0.05). No significant differences were found between the patients with and without LJM in regard to age and duration of diabetes. There were significant differences in age, duration of diabetes and HbA1c between the patients with Dupuythen's contracture and without. The prevalence of proliferative retinopathy was 61.5% in the patients with Dupuytren's contracture, and much higher than in the patients without collagen disorders (20.7%). Serum type IV collagen 7S levels were significantly higher in the patients with Dupuytren's contracture (5.77±0.93ng/ml) than in the patients with neither LJM or Dupuytren's contracture (4.89±0.64ng/ml)(p<0.01). There were no significant differences between the patients with LJM and without LJM. No significant differences were found according to the severity of LJM or Dupuytren's contracture. These findings suggest that the Dupuytren's contracture in diabetic patients may be associated with a metabolic disorder of type IV collagen, and its development may be closely associated with diabetic microangiopathy.View full abstractDownload PDF (1153K) -
Masami Nemoto, Yutaka Mori, Junichi Yokoyama, Shoichi Hata, Shuichi Ka ...1995 Volume 38 Issue 7 Pages 509-515
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effects of allogenic bone marrow transplantation (BMT) on diabetes mellitus were examined using WBN/Kob rats. WBN/Kob rats reconstituted with WBN/Kob bone marrow cells showed severe glucose intolerance. However, WBN/Kob rats (RT1U) that had been lethally irradiated (8.0 Gy) and then reconstituted with bone marrow cells from normal LETO rats (RT1U) or WF rats (RT1U) showed decreases in serum glucose and increases in serum insulin during an oral glcose tolerance test 5 months after BMT. Pathohistologically, fibrotic change in the pancreas and islet deformity were greatly suppressed in WBN/Kob rats reconstituted with LETO or WF bone marrow cells. Assessment of T cell subsets revealed that the W3/13 (pan T) and W3/25 (Th)/OX8 (Tnon-h) ratios in WBN/Kob rats reconstituted with LETO or WF bone marrow cells were significantly lower than in WBN/Kob rats reconstituted with WBN/Kob bone marrow cells. OX33 (B) in WBN/Kob rats reconstituted with LETO or WF bone marrow cells was significantly higher than in WBN/Kob rats reconstituted with WBN/Kob bone marrow cells. These findings suggent that a stem cell disorder might be involved in the pathogenesis of diabetes in this rat strain.View full abstractDownload PDF (3763K) -
Michiko Asano, Yukichi Okuda, Kunimi Hirano, Takashi Yamaoka, Yoko Tsu ...1995 Volume 38 Issue 7 Pages 517-522
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe encountered a 50-year-old man with pancreatic diabetes who had a long history of heavy alcohol consumption. His serum glucose level was elevated, and he had previously been treated with insulin by another physician. About one year previously he developed erythema of the toes, watery diarrhea, a recurrent aphthous ulcer, glossitis and a taste disorder. His serum zinc level was found to be low, 39 μg/dl (normal range: 50-140). A diagnosis of acrodermatitis due to zinc deficiency was made, and the patient was treated with oral ZnSO4, 600mg daily. After a few weeks of zinc therapy, serum zinc levels increased and most of the symptoms were resolved.After zinc treatment his glucose intolerance improved, and a slight increase in his plasma C-peptide responce to arginine infusion was observed.View full abstractDownload PDF (2954K) -
Junko Setoguchi, Hirohumi Shigeta, Hisataka Tegoshi, Katsuya Wada, Yos ...1995 Volume 38 Issue 7 Pages 523-526
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSRecently, it was reported the interferon therapy for chronic hepatitis C, often induces retinal diseases. To investigate the effects of HCV infection on diabetic complications, especially diabetic Rretinopathy, 421 patients with non-insulin dependent diabetes mellitus were examined for anti-hepatitis C virus antibody (HCVAb), hepatitis Bs antigen (HBs-Ag), and liver function. They were divided into four groups (A, B, C, D); Group A: both HCVAb and HBsAg were negative, with normal liver-function (n=335), Group B: both HCVAb, and HBsAg were negative, with liver-dysfunction (n=35), Group C: positive HCVAb (n=42), and Group D: positive HBsAg (n=9). These four groups showed no significant differences from diabetic controls. The prevalence of diabetic retinopathy in Group C (52%) was, however, significantly higher than those of groups A (29%), B (14%), and D (11%), and the prevalence of diabetic nephropathy (40.5%) was higher than those of groups A (19.1%) and B (14.3%)(p<0.05). These findings suggest that HCV infection exacerbates diabetic microangiopathy. We speculate that activated lymphocytes in HCV-infected patients, produce cytokines wchich induce diabetic damage of small vessels.View full abstractDownload PDF (633K) -
[in Japanese]1995 Volume 38 Issue 7 Pages 527
Published: July 30, 1995
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (225K)
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