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Volume 32, Issue 3
Displaying 1-11 of 11 articles from this issue
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Noriko Ujihara, Chieko Takahashi, Tetsuya Babazono, Tsutomu Sanaka, Yu ...1989 Volume 32 Issue 3 Pages 155-160
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe effects of dietary protein restriction on renal function and the development of diabetic renal failure were studied for six months. The patients were divided into three groups. Group A comprised eight patients who received a low protein diet (35-40 kcal/kg, protein 0.6-0.8 g/kg). As a control, six patients in group B received a normal protein diet (35-40 kcal/kg, protein 1.0-1.2 g/kg), while ten patients in group C received a usual diabetic diet (25-30 kcal/kg, protein 1.0-1.2 kg).
Serum creatinine (Cr), blood urea nitrogen (BUN) and serum total protein (TP) were followed up for six months.
After six months, the protein-restricted patients (group A) showed no significant elevation of BUN or Cr, while the patients in groups B and C showed significant elevations of Cr (p<0.05) and tended to have elevated BUN levels There was no reduction of TP in any group during the six months.
In the regression analysis of reciprocal Cr against time, the slope was improved after protein restriction in group A (-2.67±1.27×10-2 to-1.60±16.9×10-2, p<0.05).
These findings suggest that dietary protein restriction has a beneficial role in treating patients with diabetic renal failure.View full abstractDownload PDF (930K) -
A Long-term ObservationAkira Sasaki, Naruto Horiuchi, Kyoichi Hasegawa, Masuko Uehara1989 Volume 32 Issue 3 Pages 161-167
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRisk factors related to the development of diabetic retinopathy were studied by long-term observation along with their incidence rate and the duration from the onset of diabetes to the development of retinopathy, using a total of 976 Type 2 diabetic patients (mean age 52.1±10.9 years) who were free from retinopathy at entry to the study and were followed up for a mean of 8.3 years.
During the observation period, 322 patients (33.0%) developed dlabetic retinopathy, the incidence rate per 1, 000 person-years being 39.8. The rate was significantly related to age at noset of diabetes, fasting plasma glucose (FPG) level at entry and type of treatment, but not to systolic blood pressure or cigarette smoking.
The incidence rate increased sharply as the observation period became longer. But, at the same time, it was strongly related with glycemic control; patients with FPG ≥ 200 mg/dl had the highest incidence rate, while patients with FPG < 140 mg/dl always showed the lowest rate in each group during the observation pariod.
The mean period from the onset of diabetes to the development of retinopathy was 9.2 years, indicating an increasing trend in the period as age at onset of diabetes became younger. Among the patients whose age at onset of diabetes was < 35 years, the period was influenced largely by FPG level at entry; a longer period was observed in patients with a lower FPG level, and vice versa.View full abstractDownload PDF (1220K) -
Koichi Oshiro, Hisashi Yoshida, Fumio Nagamine, Ryuji Sunagawa, Masami ...1989 Volume 32 Issue 3 Pages 169-175
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDiabetes mellitus is well recognized as one of the risk facotrs for coronary arteriosclerosis. However, the sevenity of stenosis and morphologic characteristics of the coronary artery in diabetes mellitus have not yet been established. In the present study, the severity of stenosis and morphologic characteristics of the coronary artery were analyzed in diabetic patients with ischemic heart disease by coronary arteriography.
Twenty patients with diabetes (DM) and impaired glucose tolerance (IGT) were compared with 20 control (C) patients who were matched for age, sex and risk factors other than DM and IGT. The severity of stenosis was determined by the Gensini score, which is based on the size and location of stenotic lesions, of the coronary artery. Individual stenosis was classified by Rosch classification into six types: short concentric, short eccentric, tubular regular, tubular irregular, tubular irregular with ulcerating plaque and diffuse. The results suggested that the severity of coronary artery disease was not significantly different between DM, IGT and C patients, all of whom had similar Gensini scores, and that DM patients had more tubular irregular-type morphological stenosis than IGT and C patientsView full abstractDownload PDF (1171K) -
Katsumi Noda, Fumio Umeda, Yasuhiro Sako, Toshihiko Hashimoto, Toyoshi ...1989 Volume 32 Issue 3 Pages 177-181
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSVibratory perception threshold (VPT) in diabetic patients (NIDDM) with (n=13) or without neuropathy (n=12) and age matched control subjects (n=12) was measured at the right internal malleolus using a vibratory perception meter (TM-31A). After continuous vibratory stimulation at 150μm amplitude for 5 min, VPT was again measured at 0, 2 and 5min.
VPT in the three groups was significantly increased after the stimulation. VPT was significantly higher in both groups of diabetic patients than in controls at 0, 2 and 5min after the stimulation. Additionaly, the increment in VPT from before to after the stimulation (at 0min) showed significantly positive correlations with FPG and HbA1c level, suggesting that the change in VPT after the stimulation may be related with glycemic control in diabetic patients.
The measurement of VPT after continuous vibratory stimulation with a TM-31A revealed abnormal peripheral nerve function in diabetic patients who had no clinical neuropathy.View full abstractDownload PDF (894K) -
Fusae Abe, Mitsuyasu Yano, Meisei Hirota, Naofumi Ito, Hideo Yoshioka, ...1989 Volume 32 Issue 3 Pages 183-188
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA method for the determination of serum glycated albumin (GA) by high-performance liquid chromatography is presented. The system involves anion exchange chromatography to separate albumin, and consecutive boronate affinity chromatography to separate glycated and nonglycated albumin. Various conditions for measurement with this assay system were examined in comparison with those of fructomamine (FA).
The method is precise: CV for within-day assay ranged from 1.29 to 3.77%, and that for between-day assay was 4.94%. Assay of GA by this method was not influcenced by the protein concentration of the samples, or the presence of bilirubin, ascorbic acid or glucose, all of which interferred to some extent with the measurement of FA.
Mean recovery, calculated as the percent of added GA recovered in the supplemented samples, was 104.2%(range 99.1-108.7%). Plasma GA concentrations were not significantly different from serum GA values, while plasma FA concentrations were lower than those of serum.
The clinical reference ranges for GA and FA were 17.0-23.3% and 2.36-3.05mmol/l, respectively. These were calculated from the determination of 155 healthy subjects based on a probability plot. The GA and FA values of patients with diabetes mellitus were far beyond the respective clinical reference range.
The proposed method for the determination of glycated albumin is reliable enough to be applied for clinical use.View full abstractDownload PDF (3865K) -
Yuri Ono, Masahiko Katoh, Satoshi Tsushima, Mamoru Kudoh, Shoichi Naka ...1989 Volume 32 Issue 3 Pages 189-193
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong the chronic complications of diabetes mellitus, the changes occurring in the central nervous system (CNS) have not been well investigated because there has been no adequate method. Auditory brainstem response (ABR) has recently been used as a method to investigate CNS function, and the changes in ABR in diabetics have been reported as prolongation of the latency of each wave and prolongation of interpeak latency. However, follow-up data on ABR in diabetics have not been reported. In this study, ABR was followed for two years in 20 diabetic patients (6 males, 14 females, mean age 42.6±9.1). ABR was recorded with a DISA system 1500 that elicited binaural white click stimuli at an analysis time of 10 msec with the level set from 80dB to 120dB.
1) After 2 years, the latency of waves I, III and V was similarly prolonged and the site of prolongation of ABR was mainly wave I (peripheral nerve site).
2) There was a relationship between the change in nerve conduction velocity in the extremities and the change in wave I of ABR during the 2 years.
3) Aggravation of renal function influenced the prolongation of ABR.View full abstractDownload PDF (885K) -
Hideki Hidaka, Yuzuru Nakajima, Takahiko Aoki, Mariko Harada, Masaaki ...1989 Volume 32 Issue 3 Pages 195-201
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPeripheral vascular diseases (PVD) were clinically studied in 220 diabetic subjects in relation to risk factors for atherosclerosis. The mean age of the subjects was 58 years, and the mean known duration of diabetes was 11 years.
PVD was found in 77 diabetic subjects (35%) who fit one of the following criteria unilateral abscence of pulsation of superficial arteries, presence of arterial bruit, or abnormal ankle blood pressure determined by ultrasound Doppler equipment. The subjects who had more than one of these clinical signs showed a significant incidence of ischemic symptoms in the lower extremities, such as foot gangrene or ulcer, and intermittent claudication. The subjects with PVD were associated with more atherosclerotic diseases, e.g., cerebrovascular accidents and myocardial infarction, as well as diabetic microvascular complications, than subjects without PVD. The prevalence of PVD increased with both age and duration of diabetes. The manifestation of PVD was not significantly related to serum lipid levels.
These results indicate that the prevalence of PVD in Japanese diabetic subjects is similar to that in Western countries, and suggest that the severity of diabetes is related to the manifestation of PVD in overt diabetes.View full abstractDownload PDF (1238K) -
Hiroshi Nakamura1989 Volume 32 Issue 3 Pages 203-208
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGlomerular filtration rate (GFR), albumin excretion rate (AER), and fractional albumin clearance (FAC) were studied in eleven normal volunteers and seventeen diabetics after the consumption of 1.0g/kg body wt of either tuna fish meal or bean curd on separate days in order to evaluate the effect of short term protein administration on renal function. In normal subjects, the mean baseline GFR was 99.1±8.1ml/minute/1.48 m2, and the mean GFRs after the ingestion of tuna fish meal were 114.7±13.3 (1hr), 125.1±16.1 (2hr), and 135.0±18.1 (3hr). In these subjects, GFR did not increase significantly after the ingestion of bean curd. GFR in diabetic patients with normoalbuminuria should the same response as that in normal volunteers after the ingestion of each protein. In diabetics with microalbuminuria or massive albuminuria, GFR was not significantly increased after the ingestion of either protein. In both normal subjects and diabetics, urinary AER and FAC did not increase after either protein loading. The findings suggested that the response of GFR to acute protein loading may differ according to the amino acid composition of the protein ingested and the stage of diabetic nephropathy.View full abstractDownload PDF (1025K) -
Keiichiro Tanigawa, Hiroshi Furuya, Mikiko Kawaguchi, Yuzuru Kato1989 Volume 32 Issue 3 Pages 209-214
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined the kinetics of ketone bodies and blood glucose in a 32-year-old woman, who suffered from type la glycogen storage disease complicated by diabetes mellitus. A fasting test was carried out for 48 hours. Blood glucose and insulin levels were found to be markedly decreased 12 hours after the commencement of testing. Subsequently, ketone body levels gradually increased throughout the remainder of the test period. Ketone bodies as well as blood glucose were found to be elevated 30 and 60 min after administration of glucose. An insulin tolerance test (0.2 U/kg) demonstrated that the lowest levels of both ketone bodies and glucose occurred at 90 min. A steep rebound phenomenon for ketone bodies was observed from 150 min to 240 min, while blood glucose was not restored to its basal value even 240 min later. Thus, the profound biochemical change seen in this case was hyperketonemia. Ketone bodies appear to be efficiently utilized for energy metabolism when blood glucose is lowerd. The pathogenesis as complicated by diabetes mellitus remains unclear.View full abstractDownload PDF (954K) -
Naoki Miyamoto, Norihisa Shirakawa, Yasuhiro Kuroda, Fusae Abe, Kenji ...1989 Volume 32 Issue 3 Pages 215-217
Published: March 30, 1989
Released on J-STAGE: September 13, 2011
JOURNAL FREE ACCESSWe studied changes in the serum fructosamine (FRA) levels with aging in 127 non-diabetic children whose ages ranged from 0 to 16 years. The mean serum FRA concentration in non-diabetic children was 2.28±0.17 mmol/l and there was no signficant difference in the level between boys and girls. Statistically ignificant correlations were observed between age and the serum FRA level (r=0.47, p<0.01), as well as between age and the serum total protein level (r=0.45, p<0.01). There was also significant correiation between the serum level of FRA and total protein (r=0.47, p<0.01). This study revealed an increase in the serum FRA levels with aging in non-diabetic children, which might be due to an age-related elevation of the serum protein levels. The serum FRA levels in children must be evaluated with due consideration to these factors.View full abstractDownload PDF (441K) -
Chihiro Morita, Tetsuya Babazono, Toshika Ootani, Yukimasa Hirata1989 Volume 32 Issue 3 Pages 219-221
Published: March 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSExacTech® in a pen-sized digital glucose meter which requires 30 sec to reach a value after the appilication of whole blood, without wiping or washing of the test strip. The purpose of this study is to evaluate the accuracy of ExacTech®. When plasma samples of three different glucose levels (75 mg/dl, 165 mg/dl, and 351 mg/dl) were measured twelve times repeatedly with ExacTech®, the coefficients of variation were 8.0%, 7.8%, and 6.7%, respectively. When the venous blood glucose and plasma glucose levels from patients with diabetes were measured both with ExacTech® and with an autoanalyzer, the coefficient of correlation was 0.943 (n=156).
We cnclude that this meter is both convenient and accurate, and is of potential use for self-monitoring of hood glucose levels.View full abstractDownload PDF (2083K)
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