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Volume 48, Issue 5
Displaying 1-7 of 7 articles from this issue
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Original Article
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Kazuko Kanda, Yosuke Okada, Emiko Morita, Hidekatsu Sugimoto, Yoshiya ...2005 Volume 48 Issue 5 Pages 309-315
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSObjective : To define the life style of diabetic patients especially those in the work force and to study the problems related to treatment of diabetes in patients who require treatment during working hours.
Research design and method : The study subjects were 698 outpatients of our diabetes mellitus clinic. A questionnaire on the life style, work and home conditions and treatment modalities, was sent to these patients.
Results : (1) The mean HbA1c level of 317 working diabetic patients (7.2±1.7%) was significantly higher than that of 381 non-working diabetic patients (6.7±1.2%). (2) The proportion of alcohol drinkers and smokers was higher while the proportion of those taking regular exercise was lower in the working patients than in the non-working patients. (3) Importantly, any medication including insulin injections is needed during working hours in 22.8% of the working patients, 26.4% of whom sometimes fail to take their medications as well as insulin injections.
Conclusions : Blood glucose control of working patients may be worse than that of non-working patients, and some patients may fail to take their medications including insulin injections while at work. These alarming results emphasize the need for special programs to educate patients and their employers on the need for strict adherence to treatment of diabetes mellitus.View full abstractDownload PDF (523K) -
So Nagai, Satoshi Taniguchi, Masaaki Umetsu, Shinya Mishima, Tatsujiro ...2005 Volume 48 Issue 5 Pages 317-323
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSOctreotide therapy has proved effective in treating acromegaly. In these patients, a high incidence of impaired glucose tolerance is recognized. Octreotide acetate decreases growth hormone in over 90% of acromegalic patients, but glucose tolerance is not always improved. We studied the long-term effects of octreotide acetate on glucose metabolism among acromegalic patients. AUC glucose and AUC IRI calculated on 75 g OGTT, insulin sensitivity and β-cell function evaluated by HOMA-S and -β, HbA1c, GH, and IGF-I were assessed in patients eligible for evaluation before and after octreotide therapy. GH and IGF-I decreased significantly with octreotide therapy (p<0.01). HbA1c worsened significantly after octreotide treatment in diabetic patients diagnosed before octreotide therapy (p<0.05). HOMA-S was unchanged. HOMA-β was significantly reduced (p<0.05) after octreotide therapy. In conclusion, octreotide therapy for acromegalic patients with diabetes mellitus requires careful monitoring of glucose tolerance.View full abstractDownload PDF (245K)
Case Report
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Yoshihito Fujita, Mitsuo Fukushima, Shimpei Fujimoto, Kazuaki Nagashim ...2005 Volume 48 Issue 5 Pages 325-330
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSA 51-year-old man seen for high fever, thirst, polyposia, polyuria, and general malaise on January 25, 2002, was brought 6 days later to the emergency room with hematemesis. Laboratory data on admission was as follows : plasma glucose, 697 mg/dl ; pH 7.12 ; HbA1c, 6.0% ; and elevated serum pancreatic enzyme (elastase 1, 2,610 ng/dl ; pancreatic phospholipase A2, 1,390 ng/dl). Urinary C-peptide was not detected and anti-GAD antibody was negative. These findings suggested a diagnosis of fulminant type 1 diabetes, and insulin therapy was begun. Endoscopy showed wide-ranging mucosal erosion with hemorrhage in all surrounding tissues from the esophagus to the stomach and the duodenum, so intravenous hyperalimentation (IVH) and H2 blocker were administered. Although abdominal symptoms appear at high frequency with fulminant type 1 diabetes, this case is unique in that it includes severe symptoms such as hemorrhage and acute wide-ranging mucosal erosion in the upper gastrointestinal tract.View full abstractDownload PDF (340K) -
Kazuma Miwa, Tatsuya Haga, Jiro Nakamura2005 Volume 48 Issue 5 Pages 331-335
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESSA 48-year-old premenopausal woman diagnosed with mild dyslipidemia at 35 and type 2 diabetes mellitus at 45 and admitted in March 2003 was found to have severe dyslipidemia (total cholesterol, 421 mg/dl, triglyceride, 2,733 mg/dl) and lipoprotein electrophoresis showed a broad β pattern.
We diagnosed her with familial type III hyperlipoproteinemia (HLP) based on the apoE protein phenotype (E2/E2). She had complicated lower Lipoproreinlipase (LPL), fasting chyromicronemia, and coronary arteriostenosis. Premenopausal type III HLP patients are considered rare and Japanese type III HLP patients to have low plasma lipid.
We report this case of a premenopausal type III HLP patient with severe dyslipidemia and decreased LPL protein. We concluded that insulin resistance and decreased LPL protein play an important role in type III HLP onset and aggravation.View full abstractDownload PDF (424K) -
K. Kobayashi, H. Sato, A. Ohtake, H. Niimi, N. Sasaki2005 Volume 48 Issue 5 Pages 337-339
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS -
S. Taniguchi, S. Ikuyama, M. Yasuda, M. Mori, J. Nishimura2005 Volume 48 Issue 5 Pages 341-346
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS
Co-medical
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T. Endo, S. Hata, H. Yamazaki2005 Volume 48 Issue 5 Pages 347-353
Published: 2005
Released on J-STAGE: April 11, 2008
JOURNAL FREE ACCESS
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