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Volume 44, Issue 12
Displaying 1-7 of 7 articles from this issue
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Analysis of Examination Frequency of Metabolic States and Diabetic Complications by Health Insurance Claims for Medical Care and Questionnaires to Employees of an Electronics CompanyHideki Hidaka, Shun-ichi Furusawa, Katsumasa Tsujinaka, Yoshimitsu Yam ...2001 Volume 44 Issue 12 Pages 919-925
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSQuality of care estimated by frequency of examination of metabolic states and diabetic complications was studied in diabetic subjects at an electronics company. Subjects were 498 among 14, 073 enployees over 40 years old, judged as “requiring medical treatment for diabetes” in 1997 health check-ups. A survey in 1999 studied medical information in 1998 (response: 88%). Some 347 patients (81%) answered they were under regular medical care and 136 patients received opthalmologic examinations in the clinic during 1998. A review of health insurance claims for medical care showed 117 patients had funduscopic examinations and 74 had examinations for microalbuminuria. Of those with insulin treatment, 60% received funduscopic exami nations, but only 30% had microalbuminuria examinations. Quality of care evaluated by the frequency of examinations of metabolic states and diabetic complications was significantly better but far from ideal even in clinics with clinical diabetes specialists registered with the Japan Diabetes Society. Guidelines for the treatment of diabetes published in 1999 and revised in 2000 by the Japan Diabetes Society should be widely disseminated for better quality of care in diabetic patients.View full abstractDownload PDF (1234K) -
Takashi Kadowaki, Yasuhiko Iwamoto, Hisahiko Sekihara, Nobuakira Taked ...2001 Volume 44 Issue 12 Pages 927-933
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe studied whether plasma BNP concentration measurement was useful in screening for silent ischemia or asymptomatic cardiac dysfunctions in diabetic outpatients in daily clinical practice. Plasma BNP and ANP concentrations in 573 outpatients with diabetes were measured. Plasma BNP concentrations increased with complications of hypertension, heart diseases, cardiac dysfunction, diabetic neuropathy, diabetic nephopathy, and diabetic retinopathy. Plasma BNP also was significantly correlated with NYHA classification, blood pressure, cardio-thoracic-ratio (CTR), SV1+SV5, 6, interventricular septum thickness, posterior wall thickness, left ventricular mass, and left ventricular mass index. In subjects without heart disease, plasma ANP concentrations showed a correlation with blood glucose, but plasma BNP concentrations did not show such a correlation. Receiver operating characteristic analysis revealed that plasma BNP concentrations showed sensitivity of 62.7% and specificity of 75.0% in detecting heart diseases or cardiac dysfunction. In addition, the result of logistic regression analysis indicated that plasma BNP measurement was the best clinical parameter in the prediction of heart diseases and cardiac dysfunction. Measurement of the plasma BNP concentrations is thus useful in diagnosing heart diseases in diabetic subjects in daily clinical practice.View full abstractDownload PDF (1302K) -
Dependence on Extracellular (EC)-SODEisuke Maehata, Tetsuo Adachi, Minoru Inoue, Masao Yano, Hiroji Shimom ...2001 Volume 44 Issue 12 Pages 935-941
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTotal SOD activity and EC-SOD concentrations in the serum of 367 patients with type-2 diabetes mellitus were measured. The correlation between the two SOD was r=0.338, a significant relationship (p<0.01). High blood SOD states (total SOD>4.0U/ml) tended to depend on the level of extracellular (EC)-SOD. There were 26 patients (7.1%) in the high EC-SOD (>500ng/ml) group and341 (92.9%) in the low ECSOD (<200ng/ml) group. In the low-EC-SOD group, the correlation between EC-SOD and albumin excretion index (AEI) was r=0.170 (p<0.01). Serum EC-SOD concentrations were81.1±21.9 ng/ml in the normoalbuminuric group (N=214), 83.2±19.8 ng/ml in the microalbuminuric group (N=100) and102.9±35.3ng/ml in the macroalbuminuric group (N=27), and were significantly higher in than the healthy group (N=53) at 73.1±16.7ng/ml (p<0.01), indicating that the serum EC-SOD concentration increased with the development of nephropathy. This study therefore shows that total SOD activation is highly dependent on the level of EC-SOD, and suggests that active oxygen is related to the onset and escalation of diabetic nephropathy. EC-SOD was thus effective as a marker for this disease.View full abstractDownload PDF (1192K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2001 Volume 44 Issue 12 Pages 943-947
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
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Mariko Kajikawa, Michihiro Oya, Yoshiyuki Tsuura, Tomomi Takeda, Sekie ...2001 Volume 44 Issue 12 Pages 949-953
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 54-yar-old man was diagnosed with Wolfram syndrome without WFS 1 gene mutation.
The patient was admitted with a 3-day history of dysuria but no personal or family history of diabetes. A year earlier, he had been diagnosed with idiopathic optic atrophy.
On admission, plasma glucose was 696 mg/dl, arterial blood pH 7.25, base excess-11.6 mmol/l and ketouria was present.The patient was diagnosed and admitted for routine therapy for diabetic ketoacidosis (DKA).He was later treated with insulin injection twice a day. On admission, HbA1c was 7.2%.Islet cell antibodies and antiglutamic acid decarboxylase antibodies were negative. Laboratory determination of HLA type showed DR-4 and DR-9 haplotypes. Insulin-dependent diabetes mellitus was suggested because endogenous insulin secretion was severely reduced. During admission, he had a urinary tract infection and abdominal computed tomography (CT) showed severe hydronephrosis of the rightkidney. Because the right kidney was not functioning and might cause recurrent infection, endoscopic nephrectomy was done. The diagnosis was hydronephrosis due to congenital uretero-pelvic junction (UPJ) stenosis. Audiometry showed a dip at high frequencies. Although insulin-dependent diabetes mellitus accompanied by optic atrophy, urinary tract abnormality, and auditory disturbance suggested Wolfram syndrome, WFS 1 gene mutation was not detected by direct sequence analysis of peripheral blood leukocyte DNA.View full abstractDownload PDF (1354K) -
[in Japanese], [in Japanese], [in Japanese]2001 Volume 44 Issue 12 Pages 955-958
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2001 Volume 44 Issue 12 Pages 959-963
Published: December 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS
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