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Volume 12 (1969)
- Issue 6 Pages 429-
- Issue 5 Pages 307-
- Issue 4 Pages 221-
- Issue 3 Pages 147-
- Issue 2 Pages 65-
- Issue 1 Pages 1-
Volume 12, Issue 4
Displaying 1-14 of 14 articles from this issue
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H. Oka, S. Saito1969 Volume 12 Issue 4 Pages 221-225
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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Masateru Toyoda1969 Volume 12 Issue 4 Pages 226-232
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSInsulin has been shown to accelerate the incorporation of labeled amino acids into the protein of the isolated rat diaphragm.
1) This insulin stimulation is not exerted through an effect of the hormone on the transport of external amino acids to intracellular sites of protein synthesis.
2) The basic and insulin-enhanced incorporation of radioactive amino acids into protein of isolated cut diaphragm from normal and fasted rats is not affected by the presence or absence of glucose in the incubation medium.
3) Erythrose inhibited simultaneously the basic incorporation of amino acid and its stimulation by insulin. The effect of erythrose is not reversed by Krebs cycle intermediates, but these intermediates permit insulin to enhance protein synthesis, showing that both an intact supply of Krebs cycle intermediates and a glucose utilizing system are neccessary for insulin action.
4) Inhibition of endogenous carbohydrate metabolism in the diaphragm by 2-deoxy-glucose inhibits amino acids incorporation and abolishes the stimulatory effect of insulin.
5) The basic incorporation and its stimulation by insulin are restored to normal by addition of the metabolically active sugars, glucose and mannose.
It is concluded that protein synthesis in the isolated diaphragm and its stimulation by insulin are dependent upon some normal glycolitic reaction, but there is some difference of energy supply between the basic incorporation of amino acids and its stimulation by insulin.View full abstractDownload PDF (983K) -
E. Kimura, H. Takayama1969 Volume 12 Issue 4 Pages 232-237
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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N. Sakamoto1969 Volume 12 Issue 4 Pages 237-240
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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1969 Volume 12 Issue 4 Pages 241-245
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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H. Maezawa, T. Wakabayashi1969 Volume 12 Issue 4 Pages 246-249
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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K. Onoe1969 Volume 12 Issue 4 Pages 250-258
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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S. Nishiyama1969 Volume 12 Issue 4 Pages 258-262
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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M. Ohta1969 Volume 12 Issue 4 Pages 263-269
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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1969 Volume 12 Issue 4 Pages 270-272
Published: July 31, 1969
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1969 Volume 12 Issue 4 Pages 273-279
Published: July 31, 1969
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Hiroshi Tada1969 Volume 12 Issue 4 Pages 280-290
Published: July 31, 1969
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Hiroyuki Sando, Yasunori Kanazawa, Takeshi Kazuya1969 Volume 12 Issue 4 Pages 291-295
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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Hiroyuki Sando, Yasunori Kanazawa, Takeshi Kazuya1969 Volume 12 Issue 4 Pages 296-303
Published: July 31, 1969
Released on J-STAGE: August 10, 2011
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