All issues
Volume 37, Issue 12
Displaying 1-9 of 9 articles from this issue
- |<
- <
- 1
- >
- >|
-
Psychosocial Factors and Glycemic ControlYukikazu Kaino, Kaichi Kida1994 Volume 37 Issue 12 Pages 867-871
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (802K) -
Keigo Naka, Hideyuki Sasaki, Machi Furuta, Tokio Sanke, Kishio Nanjo1994 Volume 37 Issue 12 Pages 873-880
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSIn order to establish a method for estimating sympathetic function, the coefficient of variation of resting wave amplitudes of plethysmography (CVWH), the ratio of amplitude of plethysmography in ice water immersion to the amplitude at rest (RWH) and the recovery rate of skin temperature after 5 minutes' ipsilateral ice water immersion to the resting skin temperature (T5) were studied.
Fifty diabetics ranging in age from 15 to 60 years (mean±SE=42.5±1.9), and 58 healthy controls ranging in age from 20 to 60 years (42.9±1.6) were subjected to this study.
In this study, plethysmographic waves were continuously recorded by photoplethysmometer PT300 (Fukuda), and the skin temperature was measured by digital thermometer Digimulti (Takara).
The study in healthy controls revealed that RWH was less influenced by aging or atherosclerosis than CVWH and T5. In diabetics, RWH and CVWH were lower than those in age-matched healthy controls. Diabetics with autonomic neuropathy had a significantly lower RWH than those without neuropathy.
More detailed relationships between RWH and the severity of autonomic disturbance were evaluated in 88 diabetics. There was a close relation between RWH and the autonomic neuropathy score sum of scored symptoms, orthostatic hypotension and CVR-R. The critical point for judging abnormal autonomic function was estimated at 30% of RWH of the controls.
We conclude that the measurement of RWH using digital plethysmography in a simple, reliable and quantitative method with which to assess autonomic function, particularly sympathetic function, in diabetic patients.View full abstractDownload PDF (1331K) -
Y Kida, H Taki, H Nakagawa, A Kashiwagi, H Hidaka, R Kikkawa, Y Shiget ...1994 Volume 37 Issue 12 Pages 881-888
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe investigated the risk factors for Mönckeberg's arteriosclerosis (MA) in NIDDM and whether MA impairs peripheral circulation on the basis of foot examinations and measurements of transcutaneous PO2 (TCPO2). Radiological examinations of the lower extremities were performed in 401 NIDDM. 1) Patients to detect MA was found in 42 subjects (prevalence=10.5%). 2) Discriminant analysis demonstrated that duration of diabetes, nephropathy, peripheral neuropathy, low HDL-cholesterol, hypertension, and reduced body mass index could serve as independent risk factors for MA. 3) Both the severity and the incidence of MA are well correlated with the severity of nephropathy. 4) NIDDM with MA is frequently associated with intermittent claudication, pain at rest, gangrene, and/or peripheral pulselessness. 5) TCPO2 in the foot was significantly lower in NIDDM with MA than in NIDDM without calcification, and 66% of subjects with MA had a TCPO2≤50 mmHg. These data indicate that MA may be capable of serving as a clinical marker of peripheral vascular disease in NIDDM because of its frequent association with arterial obstruction, microangiopathy and neuropathy.View full abstractDownload PDF (1383K) -
Hiroyuki Matsushima, Yoshimitsu Yamasaki, Hideko Nishizawa, Mineo Koda ...1994 Volume 37 Issue 12 Pages 889-894
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSIn order to quantitatively evaluate atherosclerosis in borderline diabetes (BLDM), ultrasound high resolution B-mode imaging of the carotid artery was conducted to non-invasively determine the average thickness of the intimal-medial complex (avgIMC) in 92 BLDM subjects. The avgIMCs in BLDM was comparable to the valves in age-matched diabetics, but significantly higher than in 87 normal volunteers (1.17±0.20mm vs 0.73±0.09mm) 40's). Euglycemic clamping showed a significantly decrease in the glucose infusion rate of BLDM subjects than of normal volunteers. Hyperglycemic clamping a decrease in the first insulin secretory response in this group but not in second phase insulin secretion, and avgIMC was inversely (r=-0.445, p<0.05) correlated with decreased insulin sensitivity. These data indicate that BLDM subjects have advanced atherosclerosis in their carotid arteries, and that insulin resistance and the resulting hyperglycemia and heperinsulinemia may accelerate their atherosclerosis.View full abstractDownload PDF (987K) -
Mayumi Sanaka, Satomi Minei, Meimi Shimizu, Tamaki Tetsuou, Keiko Yana ...1994 Volume 37 Issue 12 Pages 895-900
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSSerum 1, 5-AG decreases in pregnant diabetics during pregnancy. To determine the reason for this we measured serum 1, 5-AG in 61 pregnant diabetics at delivery and in the cord vessels of their newborn infants by gas chromatography.
The average level of serum 1, 5-AG at delivery in 30 normal pregnant women was 10.4±5.0mg/l, whereas in pregnant diabetics it was 3.4±1.9mg/l.
The average level of cord serum 1, 5-AG in the newborn infants of normal pregnant women was 10.7±5.0mg/l, whereas in pregnant diabetics it was 3.8±1.9 mg/l. There was a significant positive correlation between maternal serum 1, 5-AG levels at delivery and the cord serum 1, 5-AG levels of their newborn infants.
The 1, 5-AG levels in maternal serum at delivery and cord serum in patients with non-insulin-dependent diabetes mellitus (NIDDM) were lower in the case of heavy-for-dates (HFD) infants than appropriate-for dates (AFD) infants. There was a negative correlation between cord serum 1, 5-AG levels and the birth weight of the newborn infants of NIDDM mothers.
These data suggest that maternal 1, 5-AG crosses the placenta and is related to the growth of the fetuses of NIDDM mothers.View full abstractDownload PDF (833K) -
with Special Reference to a Study on Diabetic AngiopathiesYoshikatsu Migita, Akira Oshima, Hideyuki Wakasugi1994 Volume 37 Issue 12 Pages 901-906
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSIn the present study we investigated the occurrence of diabetes mellitus, hypertension and microangiopathies complicating chronic pancreatitis and assessed the effect of diabetic complications on the prognosis. The subjects of this study were 13 patients with pancreatic diabetes who were followed for a long period. Hypertension was detected in 6 of the 9 patients whose diabetes had been diagnosed more than 10 years previously. Control of hypertemsion was difficult in most cases. Hypertension developed 11 to 17 years (avavage; 13.5 years) after diabetes was diagnosed. Around the same time both retinopathy and mephropathy developed in 5 of these 6 patients. Blood glucose was poorlycontrolled at the time the above complications were first moted (HbA1 10.6-12.9%). Seven of the patients died. Diabetic complications are thought to have been the main cause of their death. The incidence of such complications im pancreatic diabetes is anmmost the same as in primary diabetes. Diabetic angiopathies in particular are believed to determine the prognosis of patients with pancreaticdiabetes due to chronic pancreatitis. These findings suggested that early detection and strict treatment of the above complications are important, in addition to good control of the diabetes.View full abstractDownload PDF (744K) -
Ikuyo Kusaka, San-e Ishikawa, Nobuya Fujita, Chiaki Matsumoto, Genro F ...1994 Volume 37 Issue 12 Pages 907-913
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSPyogenic hepatic abscess is a rare disease and its prognosis is unfavorable because of serious conplicationts, including sepsis and DIC. Recent progress in ultrasound and computed tomographic techniques enable us to diagnose hepatic abscess at an early stage, making it acurable disease. We have experienced 4 cases of diabete smellitus complicated by pyogenic hepatic abscess over the last 10 yenrs. There were 3 manes and 1 female with an age range of 38-66 years. Three of the 4 patients had a past history of cho1edocholithiasis and cholecystectomy. Clinical features were fever, nausea, vomiting and genernl malaise. All of the patients had poor blood sugar control. Abscesses were solitary and located in the right lobe of liver in all 4 patients. Aerobic bacteria including E. coli and Klebsiella pneumoniae were detected in the aspirated pus in 3 of the 4 patients. Gas formation was found in one patient and may have resulted from anaerobic glycolysis. Transhepatic abscess drainage and chemotherapy dramatically improved hepatic abscess. These results indicate that early diagnosis by an ultrasound and computed tomograpy approach is of great value in treating pyogenic hepatic abscess.View full abstractDownload PDF (3341K) -
Mikio Danbara, Taro Maruyama, Ryoji Iwasaki, Yutaka Suzuki1994 Volume 37 Issue 12 Pages 915-920
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 19-year-old female was first admitted to our hospital with diabetic ketoacidosis at age 13. Her diabetes was well controlled with diet therapy alone during her initial hospital stay. After treatment was discontinued, however, diabetic ketoacidosis recurred, and a total of six admissions were required. Insulin therapy was started at the time of the second admission and continuously maintained thereafter. The insulin dose was increased during each of the subsequent admissions except the sixth, when it was decreased. At the time of each admission, urine c-peptide levels were very low, comparable to those of insulin-dependent diabetes mellitus (IDDM) patients. The cpeptide levels then increased, reaching the levels of non-insulin-dependent diabetes mellitus (NIDDM) patients by the time of discharge. A 75g oral glucose tolerance test revealed a delayed CPR response, but insulin secretory capacity was intact. Neither IDDM-associated HLA types nor islet-cell auto antibodies (ICA) were found. Consequently, a diagnosis of NIDDM was made. This atypical form of NIDDM is rare and may shed light on the pathogenesis of both IDDM and NIDDM.View full abstractDownload PDF (962K) -
Rokuro Suzuki, Shiro Tanaka, Osamu Tojo, Tomofusa Ishii, Toshihiko Sat ...1994 Volume 37 Issue 12 Pages 921-924
Published: December 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe association between left ventricular diastolic dysfunction and myocardial MIBG accumulation was investigated. The subjects were 14 Type II diabetic patients who had no evidence of ischemic heat disease, LV hypertrophy or dilated cardiomyopathy as determined by exercise T1-201 myocardial scintigraphy and echocardiography. In 14 diabetic patients, isovolumic relaxation time (IRT) was measured by M-mode echocardiography, and the subjects were subdivided into two groups: Group 1, 8 patients with impaired left ventricular diastolic function (IRT≥80 msec), and Group 2, 6 patients with normal left ventricular diastolic function (IRT<80 msec). 123I MIBG myocardial scintigraphy was performed, and the myocardial accumulation of 123I MIBG was investigated.
The ratio of myocardial to mediastinal MIBG uptake was significantly (p<0.01) lower in Group 1 than in Group 2. And scintigraphic defects were significantly (p<0.05) more numerous in Group 1 than in Group 2. Patients in Group 1 had a greater frequency of cardiac autonomic neuropathy evaluated by QTc interval and coefficient of variation of R-R interval, when compared with Group 2.
These data suggest that, in diabetic patients with no evidence of ischemic heart disease, LV hypertrophy or dilated cardiomyopathy, impairment of left ventricular diastolic function is associated with cardiac autonomic neuropathy.View full abstractDownload PDF (664K)
- |<
- <
- 1
- >
- >|