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Volume 45, Issue 6
Displaying 1-8 of 8 articles from this issue
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Shigenobu Saito, Koichi Kashiwazaki, Tsutomu Hirano, Shinji Koba, Taka ...2002 Volume 45 Issue 6 Pages 391-397
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSHigh sensitivity C-reactive protein (HS-CRP) was evaluated in patients with diabetesmellitus (DM) or coronary heart disease (CHD). Diabetic patients with retinopathy (DR) were further classified to determine the relevance of microangiopathy to HS-CRP. No significant difference was seen in HS-CRP between controls and DM or DR patients.In contrast, HS-CRP was significantly higher in all CHD patients, regardless of DM or DR. In all subjects, HS-CRP correlated significaly with HDL-cholesterol and BMI. Multivariate regression analysis showed a significant contribution of HOMA-R or BMI to HS-CRP. HOMA-R was selected as an explanatory factor in all subjects or all CHD patients, and BMI in controls or all diabetic patients. In all subjects, multiple logistic regression analysis showed that the presence of CHD and insulin resistance were significant independent variables.In CHD patients, HS-CRP increasedindependently of T-C (LDL-C), LDL particle size, BMI and HOMA-R.These results suggest that HS-CRP may be a marker for coronary heart disease rather than a marker for insulin resistance or obesity.View full abstractDownload PDF (1214K) -
Shoji Kuroda, Kazuhiko Sakaguchi, Yutaka Onishi, Tetsuya Teranishi, Hi ...2002 Volume 45 Issue 6 Pages 399-405
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSOld age is one of many reported contraindications to metformin therapy. We measured plasma lactate and pyruvate in type 2 diabetes patients with or without metformin. Plasma lactate was not elevated in the metformin-treated group. Plasma lactate levels did not correlate with age. Patients with high lactate had alcoholism, heart failure, asthma, and arteriosclerosis obliterans. One was administered excess metformin. These cases were generally contraindicated, suggesting that age alone should not be considered a contraindication to metformin therapy.View full abstractDownload PDF (1024K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 6 Pages 407-410
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese], [in Japanese]2002 Volume 45 Issue 6 Pages 411-414
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Masaru Sakurai, Yasuyuki Nishimura2002 Volume 45 Issue 6 Pages 415-420
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 24-year-old woman admitted with fever and abdominal pain was found in laboratory tests to have elevated pancreatic enzyme.Abdominal ultrasonography and computed tomography showed diffuse pancreatic swelling.These findings indicated a diagnosis of acute pancreatitis.She was treated with gabexate mesilate and ulinastatin, and pancreatitis improved within a week.
On admission, urine sugar was negative, blood glucose 128mg/dl, and HbA1c4.5%, but blood glucose gradually elevated, developing into diabetes mellitus. Islet cell antibody and autoantibody to glutamic acid decarboxylase were negative. Virus antibody titers for mumps, rubella, Epstein-Barr virus, Coxsackie virus, and cytomegalovirus were also negative. Her insulin secretion severely impaired in the urinary C-peptide excretion and glucagon loading tests. This data suggested that her islet beta cells had been severely damaged by acute pancreatitis. The clinical course was interesting in that it was very similar to that of non autoimmune fulminant type 1 diabetes.View full abstractDownload PDF (1386K) -
Kanako Nishikai, Akira Shimada, Shiro Iwanaga, Yoshinori Nakagawa, Hir ...2002 Volume 45 Issue 6 Pages 421-426
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 70-year-old man diagnosed with diabetes mellitus and hypertension since the age of 30 was treated with oral hypoglycemic agents and antihypertensive drugs. He went to the hospital irregularly and his glycemic control was poor. He reported pain and numbness in the body and feet due to painful diabetic neuropathy from the age of 63. He was admitted for worsening pain and treated with 300 mg/day of mexiletine, which effectively relieved his pain. Because electrocardiography showed first-degree atrioventricular block on admission, we followed up with electrocardiography after 1 week of mexiletine administration to make sure mexiletine had no adverse effect, even though he did not report syncope, dizziness, or palpitation. Electrocardiography showed Wenckebach second-degree atrioventricular block, so we discontinued mexiletine. Fortunately, 4 days after discontinuing mexiletine, the atrioventricular conduction disturbance recovered to that at the level at admission. We thus emphasize the importance of close follow-up with serial electrocardiography after mexiletine administration to treat painful diabetic neuropathy.View full abstractDownload PDF (1188K) -
[in Japanese], [in Japanese], [in Japanese]2002 Volume 45 Issue 6 Pages 427-430
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
2002 Volume 45 Issue 6 Pages 431-454
Published: June 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (7288K)
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