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Volume 11, Issue 5
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1968 Volume 11 Issue 5 Pages 263-267
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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[in Japanese]1968 Volume 11 Issue 5 Pages 267-275
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese]1968 Volume 11 Issue 5 Pages 275-282
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1968 Volume 11 Issue 5 Pages 282-289
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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[in Japanese]1968 Volume 11 Issue 5 Pages 289-292
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese]1968 Volume 11 Issue 5 Pages 293-296
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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Fusae Tsukamoto, Masako Shimoshige, Yasue Ohmori, Ryoko Hagura1968 Volume 11 Issue 5 Pages 297-304
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSChanges in blood sugar, plasma immunoreactive insulin (IRI) and non-esterified fatty acid (NEFA) were followed serially after oral loading of 100g of glucose (SGTT) and after glucose-glucagon-tolbutamide test (GGTT) as advocated by Ryan et al. in normals and in diabetics.
1) Following SGTT, diabetics were divided in two groups according to the peak values of serum IRI. In group A with peak values higher than 80μU/ml, the highest blood sugar values was more than 300mg/dl in only one of the 5 cases. In groupB with peak values of plasma IRI less than 80μU/ml, the highest blood sugar values exceeded 300mg/dl in all 11 cases. This revealed a close correlation between plasma IRI response and blood sugar after SGTT.
2) In normals, plasma IRI after GGTT increased rapidly to 978±163μU/ml in 5 minutes and decreased steeply thereafter.
3) IRI response after GGTT in diabetics showed similar brisk response and rapid return. The peak values, however was much lower even in group A, who were supposed to have milder diabetes, showing a mean of 271±37.9μU/ml and the highest value of only 384μU/ml. The peak values were reached not later than the normal controls.View full abstractDownload PDF (954K) -
Nobuo Kasahara1968 Volume 11 Issue 5 Pages 305-313
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRenal gluconeogenesis was experimentally proved with kidney slices in vitro. In vivo it was proved, however, only in hypoglycemic state. The present paper deals with the renal gluconeogenesis in diabetic rats under eviscerated conditions.
Method: Groups of normal rats, alloxan diabetic rats and steroid administered rats were each divided into two groups, i.e. one group of eviscerated rats with kidney and the other group of those without kidney. Decrease of blood sugar within one hour afth- evisceration, blood glucose entry ascertained by means C-glucose, and incorporation of C from C-actate into blood sugar were observed in each group above mentioned.
The results are as follows:
1) In normal rats, no significant differences in decrease of blood sugar after evisceration could be found between the group with kidney and that without kidney.
2) In diabetic rats and steroid-administered rats, however, the rats of decrease of blood sugar in group with kidney was smaller than that of the group without kidney.
3) The blood glucose entry in diabetic state occurred in the group with kidney. It hardly occured in the other group without kidney.
4) Incorporation of C from C-lactate into into blood sugar was seen to small extent in normal rats underglucose loading condition. But it was seen to remarkable extent in diabetic state.
It is suggested as follows:
1) Eviscerated animals are useful for investigation on renal gluconeogenesis.
2) Renal gluconeogenesis of normal animals under eviscerated condition was recognized to small extent in hypoglycemic state, and also to smaller extent under glucose loading condision.
3) An increased renal gluconeogenesis in diabeticanimals under eviscerated condition would be due to endcrinological abnormality rather than to high blood sugar levels. It may be considered that kidney has also some regulation in diabetic state, as it is the case with liver.View full abstractDownload PDF (1513K) -
Nobuo Kasahara1968 Volume 11 Issue 5 Pages 314-318
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn the previous investigation of the author, increased renal gluconeogenesis in diabetie was observed as a result of studies on eviscerated rats with kidney. In present report, effect of insulin on renal gluconeogenesis in alloxan diabetic rats were studied.
Method: 14C-lactate was injected intrayenouly to eviscerated diabetic rats with kidney and blood samples were withdrawn at the end of 30 min and 60 min after 14C-lactate injection. Incorporation of 14C from 14C-lactate into glucose was measured by glucosazon formation of each sample. Insulin (0.05u, 0.2u, 0.5u) was injected simultaneously with 14C-lactate and the rate of incorporation of 14C into blood glucose was compared with that of the control. Blood glucose was analysed by means of 14C-glucose in order to ascertained glucose entry and effect of insulin on the glucose entry in eviscerated diabetic animals was investigated.
Results: The effect of insulin in dose of 0.05u on incorporation of 14C from 14C-lactate into blood glucose in eviscerated alloxan diabetic rats was not observed. Insulin in dose of 0.2u did not affect the incorporation of 14C from 14C-lactate into blood glucose in eviscerated alloxan diabetic rats whose blood sugar levels were higher than 200mg/dl, but it suppressed the incorporation of 14C from 14C-lactate into blood glucose in rats whose blood sugar levels were lower than 200mg/dl. With the administration of insulin in dose of 0.5 u, the incorporation of 14C from 14C-lactate into blood glucose and blood glucose entry were definitely suppressed.
It is suggested that insulin directly affects the glucose metabolism in kidney and suppresses the increased renal gluconeogenesis in diabetic animals.View full abstractDownload PDF (803K) -
SDT-25Yukimasa Hirata, Yoshihiro Nakamura, Sadahide Inuzuka, Shibanosuke Kat ...1968 Volume 11 Issue 5 Pages 319-323
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSide effects such as nausea and vomiting occurred frequently during the standard glucose tolerance test. In our experience frequency of side effects shown in 608persons tested with 100g of glucose was 45.7percent.
Adding some flavors or changing the concentration of glucose in test solutions could not affect the frequency of side effects.
One new test solution (SDT-25) which consisted of hydrolyzed starch was administered in 240persons and the frequency of side effects of SDT-25was much less than that of glucose solution (p<0.01).
It was proved that blood sugar levels after SDT- 25ingestion were almost equal to those after glucose ingestion.View full abstractDownload PDF (814K) -
1968 Volume 11 Issue 5 Pages 324-331
Published: September 20, 1968
Released on J-STAGE: August 10, 2011
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