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Volume 42, Issue 3
Displaying 1-9 of 9 articles from this issue
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Toshika Otani, Hiroki Yokoyama, Akiko Sato, Junnosuke Miura, Hitomi Ya ...1999 Volume 42 Issue 3 Pages 179-185
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe examined Japanese diabetic patients with diagnosis before the age of 30 and evaluated their cases to ditermine if a time-trend for the calendar year existed in the following categories: onset age of diabetes, type of diabetes and gender difference. Between 1980 and 1995, 2, 176 Japanese patients were registered in our Diabetes Center with onset of diabetes before the age of 30. Of these 2, 176 patient, 841 (39%) had insulin-dependent diabetes mellitus (IDDM), and 1, 335 (61%) had non-insulin-dependent diabetes mellitus (NIDDM). The time-trend regarding these categories was investigated by assigning patients to the following groups: group A, diagnois between 1960 and 1975, group B, diagnosis between 1976 and 1985, and group C, diagnosis between 1986 and 1995. NIDDM patients with a diagnosis before the age of 9 were present in all three groups. The numbers of both male and female IDDM patients with onset after 20 years of age, were increased in group C, but not in groups A and B (p<0.0001). Regarding NIDDM, the number of male patients with a diagnosis between the ages of 14 and 17 years was more increased in groups A and C than that in group A (A vs B; p<0.0001, A vs C; p<0.0001). The number of female NIDDM patients showed a similar finding in all three groups as in male NIDDM patients.View full abstractDownload PDF (869K) -
Hiroshi Nakamura, Osamu Nakagawa, Nagayuki Tani, Seiki Ito1999 Volume 42 Issue 3 Pages 187-191
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSIn order to elucidate the effect of biguanide on changes in the glomerular filtration rate (GFR) after ingestion of protein, 15 healthy volunteers were studied. The following variables were determined before and after eating cooked beef containing O.8g protein/kg of body weight with and without metformin: GFR, concentration of plasma amino acids, serum lactate. GFR rose significantly (p<0.01) after ingestion of cooked beef. Increased GFR after ingestion of beef was suppressed by administering metformin pretreatment. The increases in plasma alanine and serum lactate after ingestion of beef with metformin pretreatment were larger (p<0.05) than after ingestion of beef alone. Thus, metformin reduces the GFR increase response after ingestion of meat. These results suggest that biguanide inhibits glomerular hyperfiltration induced by the intake of proteln.View full abstractDownload PDF (663K) -
Molecular Biological Analysis of ICAM-1 ExpressionMasaki Ohtsuka1999 Volume 42 Issue 3 Pages 193-200
Published: March 30, 1999
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSAtherosclerotic changes in human arteries demonstrate expression of the inter cellular adhesion molecule-1 (ICAM-1) on endothelial cells and the subsequent attachment of monocytes.
The effects of high concentrations of D-glucose on the expression of ICAM-1 by cultured human endothelial cells were examined by immunofluorescence microscopy and reverse transcription polymerase chain reaction (RT-PCR) analysis.
Immunofluorescence staining revealed that cultured endothelial cells in the presence of 30 mM of D-glucose resulted in an increase in ICAM-1 expression, relative to that apparent for cells culutred at 5 mM D-glucose.
Similarly, RT-PCR showed that exposure of cells to 30mM D-glucose resulted in a significant increase in the amount of ICAM-1 mRNA (p<0.03).
The antioxidant N-acetyl-L-cysteine (NAC) at a concentration of 10 mM reduced the abundance of nuclear factor κB (NF-κB) and ICAM-1 mRNA in cells cultured in fibronectin-coated dishes, but had no effect on laminin-coated dishes.
Furthermore, high concentrations of glucose (30mM) increased the amounts of ICAM-1 and NFκB mRNAs in cells cultured on either fibronectin or laminin.
These results suggest that the nature of the extracellular matrix can influence NF-κB signaling in the endothelial cells and that high concentrations of D-glucose increase the expression of both ICAM-1 and NF-κB.View full abstractDownload PDF (2505K) -
Akira Kanamori, Chikara Aoki, Yoshitada Yajima1999 Volume 42 Issue 3 Pages 201-207
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe studied the effect of callus lesions on plantar pressures, and whether callus removal or wearing well-cushioned shoes reduced pressure at callus sites.
We measured plantar pressure in five patients with diabetic neuropathy and plantar callosities (six metatarsal heads and two great toes), using the foot-pressure distribution analyzing system, F-SCAN (Tek-Scan, Inc., USA). While subjects were standing barefoot, peak pressures (mean±SD) were significantly higher at eight callosity sites (2, 788±1, 772g/cm2) than at the same sites in twenty healthy subjects (451±247). Furthermore, peak pressures at these sites were significantly higher while walking barefoot than while standing still. With treatment, peak pressures were reduced in these areas by 53% from 2, 788±1, 772 to 1, 313±618g/cm2 (p<0.05). In addition, wearing well-cushioned Doctor shoes (Lowell Shoe, Inc., USA) reduced peak pressures by 67% before treatment of callosities and 79% after treatment.
These results suggest that a callus acts as a foreign body elevation plantar pressures, which can be reduced by callus removal and by wearing well-cushioned shoes, and thus, may prevent foot ulceration in diabetic patients with neuropathy.View full abstractDownload PDF (1327K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 3 Pages 209-213
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Yuko Murase, Sachiko Yoshimoto, Kosei Ueda, Minoru Noto1999 Volume 42 Issue 3 Pages 215-219
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe present a case of a 69-year-old diabetic woman with group B streptococcal metastatic endophthalmitis. After the onset of diabetes at age 59, her glycemic control was poor. She was admitted to our hospital because of bilateral loss of vision. On admission, she suffered from cellulitis in her right gluteal region, and both blood and vitreal cultures were positive for group B streptococcus. Her diagnosis was group B streptococcal metastatic endophthalmitis, and she was treated with intravitreal injection of imipenem/cilastatin and intravenous injection of imipenem/cilastatin, clindamysin and piperacillin sodium. Eventually, she underwent bilateral enucletion. Diabetes mellitus is reported as the most frequent risk factor of metastatic bacterial endophthalmitis. Therefore, for immediate diagnosis, physicians should consider that diabetic patients who present with both systemic infection and acute ocular symptoms may have an endogenous infection.View full abstractDownload PDF (1364K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 42 Issue 3 Pages 221-225
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
[in Japanese], [in Japanese]1999 Volume 42 Issue 3 Pages 227-228
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (398K) -
1999 Volume 42 Issue 3 Pages 229-256
Published: March 30, 1999
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (8443K)
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