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Volume 47, Issue 1
Displaying 1-13 of 13 articles from this issue
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[in Japanese]2004 Volume 47 Issue 1 Pages 1
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 1 Pages 3-5
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 1 Pages 6-8
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 1 Pages 9-11
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 1 Pages 12-13
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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[in Japanese]2004 Volume 47 Issue 1 Pages 14-17
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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Maki Bunno, Akira Hibino, Haruhisa Otani, Masatoshi Mune2004 Volume 47 Issue 1 Pages 19-25
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe studied the relationship between the low-density lipoprotein (LDL) migration index (LDL-MI) and serum lipids, ankle brachial index (ABI), pulse wave velocity (PWV), and other clinical parameters in type 2 diabetic patients. LDL-MI in diabetic patients (0.367±0.037) were significantly higher than those in healthy controls (0.332±0.026)(p<0.0001). LDL-MI correlated positively with baPWV, FBS, HbA1c, TC, and TG, but negatively with HDL-C. LDLMI in diabetic patients with microalbuminuria was significantly higher than in those without microalbuminuria and significantly higher in those with cerebrovascular disease than in those without cerebrovascular disease. These results suggest that LDL-MI is useful for evaluating risk factors for atherosclerosis in type 2 diabetic patients.View full abstractDownload PDF (815K) -
HLA class II antigen gene is related to heterogeneity of Type 1 diabetes mellitus in Japanese childrenKeiko Nomoto, Shigeyuki Ohtsu, Noriyuki Takubo, Yukifumi Yokota, Nobuo ...2004 Volume 47 Issue 1 Pages 27-34
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSSequencing-based typing (SBT) facilitates DNA typing of HLA. Using the Match Maker and MT Navigator in combination is particularly useful for rapid DQA 1, DQB 1, and DRB 1 typing, enabling larger numbers of specimens to be rapidly and accurately typed.
To determine HLA-associated genetic factors in Japanese children with type 1 diabetes, we analyzed 166 patients with acute onset type 1 diabetes.Patients were divided into 3 groups by age at onset, i.e., 0-4, 5-9, and 10-15 years.Among them, significant positive association was seen in DQA 1*03-DQB 1*0303-DRB 1*0901, DQA 1*03-DQB 1*0401-DRB 1*0405 and DQA 1*03-DQB 1*0302-DRB I*0802 haplotypes and negative association in DQA 1*03-DQB 1*0302-DRB 1*0403, DQA 1*0102-DQB 1*0602-DRB 1*1501, DQA 1*0103-DQB 1*0601-DRB 1*1502 and DQA 1*0103-DQB 1*0601-DRB 1*0803 haplotypes. A significant positive association was seen in the DQA 1*03-DQB 1*0303-DRB 1*0901 haplotype and at onset at 0-4 years.
Analysis by age of onset suggests that, in addition to the difference in clinical course and the positive rate for islet autoantibodies, a difference may exist in the roles of HLA class II antigen genes in onset and/or progression of β-cell destruction.View full abstractDownload PDF (1308K) -
Junko Suga-Mitsuhashi, Tatsuhide Inoue, Yasutomo Fukunaga, Yasuhiro Ha ...2004 Volume 47 Issue 1 Pages 35-39
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 41-year-old woman with anorexia and stomachache on March 5, 2001, was diagnosed with acute gastritis with hyponatremia (Na: 125 mEq/l) 2 days later. Her consciousness rapidly worsened at night and she was brought to the emergency room. Laboratory data was as follows: plasma glucose: 1, 240 mg/dl, arterial blood pH: 6.9, HCO3: 2.3 mmol/l, Na: 116 mEq/l, K: 6.7 mEq/l, and urinary ketone bodies: positive. HbAic was 5.2%, but serum and urinary C-peptides were not detected. Serum concentrations of amylase, lipase, and elastase 1 were elevated, but returned to normal within 7 days. Diabetes-related autoantibodies including anti-GAD antibody and antiinsulin antibody were negative. These findings yielded a diagnosis of fulminant type 1 diabetes. Initial symptoms of fulminant type 1 diabetes may thus mimic those of gastritis or a common cold, without indicating hyperglycemia.View full abstractDownload PDF (636K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2004 Volume 47 Issue 1 Pages 41-44
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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Masaru Doi, Nozomi Fukai, Naoko Ozawa, Kouji Hagiwara, Mika Matsushita ...2004 Volume 47 Issue 1 Pages 45-50
Published: January 30, 2004
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSA 57-year-old Japanese woman admitted in April 2000 with diabetes associated with hyperthyroidismlasting 10 months had been treated with insulin for diabetes mellitus, but not for hyperthyroidism.Graves'disease was diagnosed by the presence of thyroid stimulating receptor antibody and increased uptake ofTc-99 m on thyroid scintigraphy, and treated with thiamazole. Decreased 24-hour urinary C-peptide output(8.7, μg/day)and the presence of islet cell antibodies and high titer(74, 100 U/ml)antiglutamic acid decarboxylaseantibody yielded a diagnosis of type 1 diabetes.She underwent intensive conventional insulin therapy.Immunoblotting using the patient's serum showed 65 kDa protein in the rat pancreas, thyroid, and adrenaltissues.
A possible common autoimmune abnormality may underlie the pathogenesis of the 2 disorders.View full abstractDownload PDF (1358K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2004 Volume 47 Issue 1 Pages 51-56
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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2004 Volume 47 Issue 1 Pages 57-64
Published: January 30, 2004
Released on J-STAGE: March 02, 2011
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