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Volume 45, Issue 3
Displaying 1-8 of 8 articles from this issue
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Naoko Torichigai, Masanori Iwase, Daisuke Gotoh, Yuji Uchizono, Motota ...2002 Volume 45 Issue 3 Pages 167-171
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSMuch attention is being paid to cutaneous electrogastrography as a noninvasive gastric function test. We studied electrogastrography in diabetic patients without upper gastrointestinal symptoms from the standpoint of autonomic neuropathy in 19 asymptomatic diabetic patients and 7 healthy controls. Diabetic patients were divided into those without (n=10) and those with autonomic neuropathy (n=9) based on heart rate variability tests. The percentage of time in normal 3 cpm did not differ between control and diabetic patients with and without autonomic neuropathy before a meal, whereas after a meal, it was significantly lower in those with autonomic neuropathy than in controls (67±10% in controls, 48±6% in diabetics without autonomic neuropathy, 37±9% in diabetics with autonomic neuropathy, p< 0.05 vs controls). The postprandial? to-fasting power ratio tended to decreased in diabetic patients compared to controls. We found that abnormal electrogastrography may be associated with autonomic neuropathy in asymptomatic diabetic patients, suggesting that electrogastrography may be useful for detecting gastric autonomic neuropathy.View full abstractDownload PDF (852K) -
Hiroko Takaike, Junnosuke Miura, Mari Ohsawa, Yasuko Uchigata, Yasuhik ...2002 Volume 45 Issue 3 Pages 173-180
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSPoor glycemic control greatly influences the development of diabetic complications, and acceleration of the polyol pathway is one of the main factors causing microangiopathy. We clarified whether the urinary excretion of polyol products was related to clinical severity of diabetic complications in 153 type 1 diabetic patients whose urinary albumin creatinine ratio (ACR) was under 100 meg. Cr. Optic fundi were checked by ophthalmologists and ACR, type IV collagen creatinine ratio (U-IV-C), and urinary polyol products such as sorbitol, fructose, and myo-inositol were measured by using a single-void first morning urine. Patients with retinopathy excrete more fructose and myo-inositol greater than those without retinopathy. ACR showed no relationship with urinary polyol products. Urinary type IV collagen independently showed a positive correlation to urinary myo-inositol. Production of type IV collagen was accelerated by high glucose, thought to indicate expansion of the mesangium. Increased urinary myo-inositol may reflect activation of the polyol pathway in the diabetic kidney. Measurement of both urinary myo-inositol and U-IV-C is important in ascertainig the existence of renal impairment caused by high glucose.View full abstractDownload PDF (967K) -
Masahito Katahira2002 Volume 45 Issue 3 Pages 181-185
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 66-year-old man diagnosed with diabetes mellitus in 1990 mainly treated by diet had hemoglobin A1c ranging from 6.2% to 8.9% before 1998, but exceeding 10.0% after 1998. He was referred due to sulfonylurea failure in September 2000. Since casual plasma glucose (202 mg/dl), hemoglobin A1c (14.5%) and antiglutamic acid decarboxylase (GAD) 65 antibody titer (79.4 U/ml) were all elevated and small intestinal tumors were detected by computed tomography (CT), he was admitted. Urinary C-peptide (CPR) was low (6.4μg/day), andbothanti-insulin antibody and anti tyrosine phosphatase-like protein islet antigen-2 (IA-2) antibody were negative. Although the histology of the small intestinal tumors was found to be gastrointestinal stromal tumor (GIST) and urinary CPR was elevated (77.9μg/day) Postoperatively, anti-GAD 65 antibody titer remained high.An examination of human leukocyte antigen (HLA) showed 3 resistant alleles- DRB1*1502, *0403, and DQB1* 0601- and 1 susceptible allele-DQB1*0302-to type 1 diabetes mellitus. Since resistance is said to be dominant in susceptibility, DRB1*0403-DQB1*0302 is a neutral or resistant haplotype and DRB1*1502-DQB1*0601 is a resistant haplotype to type1diabetes.This case shows that slowly progressive type1diabetes with resistant haplotypes can become insulin-independent after the removal of impaired glucose tolerance due to factors such assmall intestinal tumors.View full abstractDownload PDF (1151K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 3 Pages 187-190
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Tsuyoshi Tanaka, Kohei Morioka, Misa Tsuji, Moriharu Misaki2002 Volume 45 Issue 3 Pages 191-194
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 41-year-old woman hospitalized for general malaise and thirst on January 28, 2000, had glycemia at 437 mg/dl, positive urinary ketone bodies, and blood gas analysis of p H7.288, HCO313.2mmol/l, compatible with diabetic ketoacidosis. Her Hb A1cwas near normal (6.3%). Serum concentrations of amylase, elastase 1, and lipase were elevated, but she had no symptoms of acute pancreatitis. Because tests for anti-GAD and IA-2 antibodies and ICA were negative, her disease was diagnosed as fulminant type 1 diabetes mellitus. Urinary C-peptide on admission was low (9.5μg/day), but recovered to normal, 32.0-34.6μg/day. The results of the arginine loading test showed improved insulin secretion. Her HLA typing was A 24, DRB 1*0405, 0901, DQB 1*0401, and *0303. We believe this case is instructive because improved insulin secretion in fulminant type 1 diabetes is considered relatively rare.View full abstractDownload PDF (580K) -
Hirofumi Ohnishi, Shigeyuki Saitoh, Satoru Takagi, Junichi Ohhata, Tak ...2002 Volume 45 Issue 3 Pages 195-198
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe usefulness of pulse wave velocity (baPWV) as an indicator of early-stage atherosclerosis in impaired fasting glucose was studied in 232 subjects randomly selected from a rural community in Japan. Body mass index (BMI), systolic blood pressure (SBP), fasting blood sugar (FBS), lipid parameters, ankle brachial pressure index (API), and baPWV were measured in each subject. API and baPWV were measured by ABI-form (BP-203 RPE; Nihon Colin). Subjects were divided into 3 groups based on FBS: a healthy group of subjects with FBS<110 mg/dl, an impaired fasting glucose (IFG) group of subjects with FBS of 110-125 mg/dl, and a diabetes mellitus (DM) group of subjects with FBS≥126 mg/dl and subjects taking hypoglycemic agents. Parameters were compared among groups. We found that the higher the plasma glucose, the higher the baPWV. Significant differences were found between baPWV in the healthy and IFG groups (1518 cm/s vs. 1673 cm/s ; p= 0.01) and in the healthy and DM groups (1518 cm/s vs. 1771 cm/s; p<0.0001). Multiple regression analysis showed that FBS was closely related to baPWV, age, and SBP, suggesting that IFG be strictly controlled to prevent the progression of atherosclerosis.View full abstractDownload PDF (596K) -
Noriyuki Sato, Hiroyuki Kase, Manabu Suzuki, Hideo Iijima, Yoshiaki Ka ...2002 Volume 45 Issue 3 Pages 199-204
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSProbucol is known to have an antioxidant effect, but its effect on serum malondialdehyde-modified LDL (MDA-LDL) is unknown. We studied the effect of 3-month probucol treatment on MDA-LDL and other lipids markers [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipid peroxidation (LPO), lipoprotein a (Lp (a)), and remnant-like particle cholesterol (RLP-C)] in type 2 diabetic patients with hypercholesterolemia.
At the start of treatment, MDA-LDL correlated positively with LPO, TC, LDL-C, and HbA1c (p<0.05). Probucol treatment significantly reduced MDA-LDL, LPO, TC, HDL-C, and LDL-C (p<0.05), although other markers were not changed. Furthermore, % change in MDA-LDL by probucol treatment also correlated positively with % changes in both LPO and HbAic.
This data suggests that probucol reduced MDA-LDL in type 2 diabetic patients. Probucol is thus useful in improving dyslipidemia quantitatively and qualitatively in type 2 diabetic patients.View full abstractDownload PDF (649K) -
2002 Volume 45 Issue 3 Pages 205-217
Published: March 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (2816K)
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