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Volume 45, Issue 11
Displaying 1-8 of 8 articles from this issue
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Sunao Matsubayashi, Toshio Mukuta, Akihito Sakanaka, Shin-ichi Miyagaw ...2002 Volume 45 Issue 11 Pages 783-789
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe evaluated the relationship of the personality trait according to Tokyo University Egogram (TEG) toHbAic in 61 type 2 diabetic patients of 42 men and 19 women (52.8±12.0 years of age, 9.9±9.5 years of illness, and 24.5±4.5 kg/m2 of BMI) maximal up to 36 months after the education of diabetic inpatient.TEG is consisted of five categories of critical parent (CP), nurturing parent (NP), adult (A), free child (FC), and adapted child (AC). The complications were 25 patients for obese, 27 patients for neuropathy, 15 patients for retinopathy, 8 patients for nephropathy, and 17 patients for macro-angiopathy. The diet therapy alone, oral hypoglycemic agent, and insulin therapy were applied for 4 patients, 33 patients, and 24 patients, respectively. HbA1c from all patients decreased to 7.5±1.8% at 3 months after the education from 10.5±2.3 % before the education. However, HbAic gradually increased since 6 months after the education.Although there was no significant difference between two groups of the high score and the low score of CP, NP, A, or FC divided from the median, HbAic from the group of high score of AC was significantly increased since 15 months after the education compared to that from the group of low score of AC.In conclusion, diabetic patients having the high score of AC related to the personality of low self esteem and/or co-dependant to others seems to be that their blood glucose control was gradually worsen although which initially improved due to the education applied to them.View full abstractDownload PDF (920K) -
T. Akiyama, K. Kanda, H. Yoshikawa, Y. Hirohata, Y. Kihara, H. Nakamur ...2002 Volume 45 Issue 11 Pages 791-795
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe studied whether long-term treatment using α-glucosidase inhibitor (α GI), acarbose, prevents thed evelopment of impaired glucose tolerance (IGT) into diabetes.
Subjects with IGT were divided into 2 groups matched for age, gender, and body mass index (BMI).Subjects were trained in diet therapy (2, 5 kcal/kg body weight) before the study and treated with (group A) or without (group B)α-glucosidase inhibitor (α-GI) for 6 months.Subjects underwent a 75 g oral glucose tolernce test (OGTT) with serum glucose and insulin concentration measured at 0, 60, and 120 min before and after 6 months of treatment.Insulin resistance was assessed by the homeostasis model assessment (HOMA-R) index.Serum glucose before or after glucose loading in both groups was reduced significantly after treatment.Serum glucose in group A were not significantly reduced compared to those in group B, however, the HOMA-R index of group A was more reduced than that of group B (A: 3.64±0.01 vs 2.07±0.01, B: 3.64±0.02 vs 2.86±0.01;p<0.05, before vs after), suggesting that the insulin resistance of group A was significantly improved compared to that of group B (p<0.05).Our results suggest that α GI treatment in high-risk subjects before diabetes onset prevents IGT from developing into diabetes.View full abstractDownload PDF (722K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2002 Volume 45 Issue 11 Pages 797-802
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Koichi Mori, Takayuki Yokoyama, Takayuki Yamada, Masahide Nakao, Tomoa ...2002 Volume 45 Issue 11 Pages 803-807
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 66-year-old man admitted for impetigo with methicillin-resistent Staphylococcus aureus (MRSA) had type 2 diabetes for over 20 years and was on hemodyalysis for the last 3 years.After impetigo developed into diabetic gangrene, he has the right leg amputated. Generally, impetigo has a good prognosis, and is most common in children in warmer seasons. We assumed that his clinical course is related to susceptibility to bacterial infection, since he had diabetes mellitus and was undergoing hemodyalysis. When a diabetic patient on hemodyalysis develops impetigo, we should immediately start intensive care for both general and local control of the infection to prevent diabetic gangrene.View full abstractDownload PDF (1310K) -
Kohei Yamaguchi, Junri Minamino, Hirokuni Sumi2002 Volume 45 Issue 11 Pages 809-814
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 45-year-old woman being treated for hypertension was found to have diabetes mellitus of recent onset. The patient was 165 cm tall, weighed 100 kg, and had a blood pressure of 146/82mmHg. After 6-month diet therapy with or without mazindol, her fasting plasma glucose (FPG) at 170mg/ dl and HbAic at 7.4% remaind high and troglitazone therapy (400mg/day) was begun, being continued for 2.5 years, during which FPG and fasting serum insulin (f-IRI) were regularly measured and insulin sensitivity was evaluated based on a homeostasis model assessment (HOMA) i ndex FPG×f-IRI/405). Immediately before therapy, the HOMA index was 6.2. During the first 6 months, it decreased to 2.0, but at 13 months was 3.7. Her weight, which was 89 kg at the beginning of troglitazone therapy, had decreased to 85 kg at 6 months, but rose to 92-93 kg at 12 months and remained unchanged during the second year of therapy. HbA1c was relatively low during the early stages of troglitazone therapy, but rose gradually thereafter. We thus recorded, an excellent correlation between changes in the HOMA index, in body weight, a nd in f-IRI through the entire clinical course of therapy. There was not derangement of diet and exercise therapy during weight gain. We changed her medication to metformin 2.5 years after the introduction of troglitazone, markedly improving glycemic control and the HOMA index.View full abstractDownload PDF (664K) -
Yosuke Okada, Takahisa Tanikawa, Nobuo Inokuchi, Ayumi Fukushima, Haru ...2002 Volume 45 Issue 11 Pages 815-820
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe present a rare case in which an 85-year-old woman's insulinoma was well controlled with low-dose octreotide therapy. She had hypoglycemic symptoms for 5years that had improved when she ate, so she gained about 10kg in the last year. When she was admitted, she was drowsy due to hypoglycemia. She had hyperinsulinemia (IRI 37μU/ml) despite hypoglycemia (PG 39mg/dl). Abdominal computed tomography (CT) showed a pancreatic tumor and angiography showed tumor staining at the same site. Arterial stimulation by calcium and venous sampling evaluation was positive, so we diagnosed her with insulinoma due to the pancreatic tumor, hyperinsulinemia, and radiographic findings. Due to high surgical risk factors, we decided to treat her with medication. As serum indulin decreased and plasma glucose level increased in an octreotide loading test 100μg, we treated her with 100μg of octreotide daily, after which her hypoglycemia completely disappeared. As her plasma glucose was elevated by 100μg of octreotide once a day and 75g-OGTT showed a diabetic pattern, we decreased the dose of octreotide from 100μg to 75μg. However, she has not had hypoglycemic symptoms and has enjoyed good quality of life since treatment was started. This is, to our knowledge, the first case report of hypoglycemia disappearing with once daily octreotide treatment.View full abstractDownload PDF (1376K) -
[in Japanese], [in Japanese], [in Japanese]2002 Volume 45 Issue 11 Pages 821-824
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Usefulness of Venous Blood Method As a Standardized Comparative Method for Blood Glucose Measurement Using Devices for Self-monitoring Blood GlucoseMakoto Tominaga, Isao Kobayashi, Katsuhiko Kuwa, Izumi Takei, Tadao Ho ...2002 Volume 45 Issue 11 Pages 825-834
Published: November 30, 2002
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe Japan Diabetes Society (JDS) Committee on Standardization of Laboratory Testing Related to Diabetes Mellitus surveyed in 1999 the device-to-device variation in blood glucose measurement among 6 selfmonitoring blood glucose (SMBG) devices, and reported significant deviation. The committee suggested that the device-to-device variation was due to the difference in manufacturers'own comparative method and proposed to SMBG manufacturers the venous blood method as a standardized comparative method. Venous blood samples with various glucose levels were made from heparinized venous blood, drawn from healthy subjects, either incubated at 37°C for 4 hours or not, and then were mixed with salined glucose solution added at different concentrations. Blood glucose in these blood samples was then measured with SMBG devices adjusted to the levels of glucose determined with conventional hexokinase method. Results for 10 SMBG devices confirmed the usefulness of venous blood as a standardized comparative method. In the 10 SMBG devices tested, the bias, difference in and mean glucose'levels between hexokinase and SMBG devices were scattered almost in a range of±15 mg/dl, and Sy/x, standard errors of regression equations, were less than 10 mg/dl.View full abstractDownload PDF (1533K)
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