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Volume 40, Issue 10
Displaying 1-12 of 12 articles from this issue
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[in Japanese]1997 Volume 40 Issue 10 Pages 641-642
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
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[in Japanese]1997 Volume 40 Issue 10 Pages 643-645
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
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[in Japanese]1997 Volume 40 Issue 10 Pages 647-649
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]1997 Volume 40 Issue 10 Pages 651-653
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese]1997 Volume 40 Issue 10 Pages 655-658
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
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Takahiro Kawano, Kimiaki Nishiura, Norio Kurumatani, Yoshiko Dohi, Kun ...1997 Volume 40 Issue 10 Pages 659-663
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo investigate a possible relationship between diabetes mellitus and the incidence of colon cancer, a cross-sectional study was performed. The subjects were 391 patients (235 males, 156 females, average age 61 years) who had been examined by total colonoscopy in Oyodo Municipal Hospital. The relationship between diabetes mellitus and the occurrence of colon cancer was examined by the odds ratio. Colon cancer was detected in 17 of the 57 patients with diabetes mellitus (30%) and in 48 of the 334 patients with normal glucose tolerance (14%). The prevalence odds ratio of colon cancer in patients with diabetes mellitus against patients with normal glucose tolerance was 2.35 (95% confidence interval: 1.23-4.48). These results suggest that diabetes mellitus may affect the incidence of colon cancer.View full abstractDownload PDF (706K) -
Norihiro Hirai, Akira Kanamori, Kiyokazu Matoba, Yoshitada Yajima1997 Volume 40 Issue 10 Pages 665-672
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe relationship of glomerular filtration and tubular reabsorption of albumin to urinary albumin excretion (UAE) was investigated in 42 NIDDM patients (DM) and 10 healthy controls (C) by inhibiting tubular reabsorption of albumin using 1-lysine loading. Based on the urinary albumin excertion rate (AER, μg/min), the NIDDM patients were divided into 3 groups: DM-I (n=22), AER<15 ; DM-II (n=13), AER 15-40 ; and DM-III (n=7), AER≥40, <200. Base-line AERs and the AERs after I-lysine loading (glomerular albumin excretion rate, GAE) were 6.7±0.84 (mean±SEM) and 180.4±8.3 in C, 6.2±0.8 and 180.7±10.6 in DM-I, 34.3±5.2 and 208.4±22.3 in DMII and 143.2±2.1 and 237.8±20.3 in DM-III. The baseline AER was correlated with GAE (r=0.366, p<0.05). The ratio (%) of albumin reabsorbed by tubules (GAE-baseline AER) to GAE was 96.3±0.5 in C, 96.5±0.4 in DM-I, 80.8±3.1 in DM-II and 40.4±7.3 in DM-III, and this ratio was inversely correlated with UAE (r=-0.933, p<0.001). In microalbuminuric patients with NIDDM, tubular reabsorption of albumin decreased as AER increased. These results suggest that in patients with AER≤40, the influence on UAE of decreasing tubular reabsorption was greater than that of increasing glomerular filtration, whereas the reverse was true in patients with AER>40, the influence on UAE of increasing glomerular filtration was greater than that of decreasing tubular reabsorption.View full abstractDownload PDF (1373K) -
Yusuke Tando, Teruo Nakamura, Toshihiro Suda, Kazuo Takebe1997 Volume 40 Issue 10 Pages 673-678
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 58-year-old man with non-insulin dependent diabetes mellitus (NIDDM), in whom diabetes mellitus was detected at age 45 but was not regularly treated, complained of mild fever, general fatigue and appetite loss. Paralytic ileus was suspected on the basis of laboratory data, the clinical findings of dehydration and abdominal swelling and the findings of gas in the small and large intestine on abdominal x-ray film. After admission, computed tomography showed a large amount of gas in the abdomen and an abscess with niveau behind the right kidney. So the patient was diagnosed as having a retroperitoneal abscess. After correction of blood glucose levels by insulin administration, treatment of the dehydration and antibiotic therapy, the abscess was surgically drained. Cultures of the drained pus were positive for Klebsiella pneumomiae. The patient had a fever again 8 weeks after his admission. The abscess was reopened and drained and the patient was doing well and had not had any recurrence of symptoms. Retroperitoneal abscess is a comparatively rare disease. In Japan, 74 cases of retroperitoneal abscess have been reported in the last 5 years. Twenty-two of the cases had diabetes mellitus. In 11 of these cases, diabetes mellitus was concerned in their onset.View full abstractDownload PDF (4947K) -
Yoshikazu Umeno, Yoshirou Ota1997 Volume 40 Issue 10 Pages 679-684
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 60-year-old woman had been experiencing thirst and fatigue since the spring of 1991. The symptoms gradually increased, and she was treated by a local medical doctor. The first diagnosis of diabetes mellitus was made at this time, and an oral hypoglycemic agent was administered. However, she consulted the medical service of our hospital because of increasing symptoms. Her height and body weight were 155 cm and 35.5 kg (BMI 14.8). The first examination in our hospital revealed a fasting plasma glucose level of 366 mg/dl and an HbA1c level of 14.3% while the urine was strongly positive for glucose and ketones. Intensified conventional insulin therapy was started. Thirty units of insulin controlled her glucose levels, and the daily doses of insulin for effective glycemic control gradually diminished thereafter. After the initiation of insulin therapy, she entered into total remission in about 1 month. Urinary CPR secretion increased from 19.5 μg/day to 43 μg/day. However, a gradual decline of C-peptide values has been observed since the remission period. Marked elevations of blood glucose recurred, and a total of 6 hospitalizations were required. The insulin dose was increased during each subsequent hospitalization. The endogenous insulin secretion was impaired in 1996. Urinary CPR was 7.6 μg/day, and ΔCPR6 during a 1-mg iv glucagon load was 0.1 ng/ml. ICA were negative while anti-GAD antibodies were positive witha value of 45 U/ ml (normal value: less than 5U/ml) in 1996. DR4 was detected in her HLA haplotype. In summary, we report a rare case of IDDM in an elderly patient who entered into remission 3 times.View full abstractDownload PDF (921K) -
Kazuhiko Sugiyama, Hideo Sasaki1997 Volume 40 Issue 10 Pages 685-690
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe report on a severely dehydrated patient with diabetic ketoacidosis associated with rhabdomyolysis following overconsumption of sugar-containing soft drinks. A 16-year-old boy who had severe obesity (body mass index 35 kg/m2) was admitted to our hospital because of unconsciousness. His HbA1c level was 10.8% suggesting that he was a diabetic. He caught a cold a week before admission. Increased insulin requirement due to upper respiratory tract infection might have exaggerated his hyperglycemia. Since then he had been thirsty and drank about 10, 000 ml of sugarcontaining soft drinks per day for seven days, and became comatose. On admission, laboratory examination showed metabolic acidosis (pH 7.05), hyperglycemia (plasma glucose: 1, 723 mg/dl), hyper-ketonemia (3-β-hydroxybutyric acid: 6, 110 μmol/l ; acetoacetic acid: 650 μmol/l) and hyper-myoglobinemia (14, 000 ng/ml). We diagnosed his condition as diabetic ketoacidosis associated with rhabdomyolysis. Although over 10, 000 ml day was infused from the first to third hospital day, his central venous pressure remained very low (0 cmH2O), indicating severe dehydration. On the third day, he completely recovered consciousness, and oral intake and subcutaneous insulin injection were begun. After treatment with insulin for 28 days, his diabetes could be controlled with diet and exercise. Serum and urinary C-peptide levels were high on the ninth hospital day (1.6ng/ml, 184 μg/day, respectively) and anti-GAD antibody was negative. He was diagnosed as having non-insulin dependent diabetes mellitus.View full abstractDownload PDF (872K) -
Makiko Yamaguchi, Koji Nakano, Motoharu Kondo1997 Volume 40 Issue 10 Pages 691-695
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe patient, a 21-year-old woman, acutely developed visual disturbance without symptoms caused by hyperglycemia. Her family history was positive for diabetes; her mother had IDDM. After examination, she was diagnosed as having IDDM and had a massive occular hemorrhage on the right and soft exudate on the left optic fundus due to diabetic retinopathy. Secretion of her growth hormone increased. She also had mild peripheral and autonomic neuropathy and nephropathy. Although photocoagulation therapy was performed with slow glycemic control by insulin therapy, a vitreous hemorrhage occurred and consequently vitrectomy of her right eye was performed 6 months after the diagnosis. In addition to the duration of diabetes and glycemic control, some factors including abnormal secretiion of growth hormone and genetic factors might be considered for early onset and acute progression of retinopathy.View full abstractDownload PDF (851K) -
Shuzo Kumagai, Miki Hidaka, Shigemi Hanamura, Hiroshi Ninomiya, Haruka ...1997 Volume 40 Issue 10 Pages 697-700
Published: October 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe purpose of this study was to investigate the profiles of sex hormone and sex hormone-binding globulin (SHBG) levels in Japanese men with impaired glucose tolerance (IGT) and those with non-insulin-dependent diabetes mellitus (NIDDM). After matching for age, some obesity indices and physical fitnesss levels, sex hormone, LH, FSH and SHBG levels in the two groups were compared. There were no siginificant differences between the groups. However, free testosterone and SHBG levels in the IGT and NIDDM groups were significantly lower than those of the control group. From these results in men, it is suggested that relative hypogonadism may exist in patients with the early phase of NIDDM and/or IGT.View full abstractDownload PDF (655K)
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