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Volume 31, Issue 5
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1988 Volume 31 Issue 5 Pages 375-376
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3611K) -
Kazuo Katsumata, Tamotsu Okada, Tatsuro Ohta, Yoshinao Katsumata1988 Volume 31 Issue 5 Pages 377-383
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSpatients with sleep apnea syndrome (SAS) underwent 75 g-OGTT, and IRI response to 75 gglucose loading was tested. Among 28 patients, 11 showed diabetic patterns, 10 showed borderline patterns and only 7 showed normal patterns of GTT. Clinical profiles of the 28 SAS patients including the 11 diabetics with SAS are given below. We also present a typical case of a diabetic patient with severe SAS.
1) There were no differences in CV of 100 heart beats at rest, results of the Schellong test, secretions of adrenalin or noradrenalin in 24-hour urine, or frequency of apnea among diabetic, borderline and normal groups. Eleven out of 28 SAS patients showed CV values lower than 2.0, although all but three patients were normal on the Schellong test.
2) IRI values at 60 and 120 minutes on the 75 g-OGTT in the borderline group with SAS were higher than those of the normal group. Insulin resistance might be present in SAS patients with borderline GTT because plasma glucose levels in these patients were higher than those in the normal group.
3) All 11 diabetic patients with SAS were NIDDM. Since the degree of autonomic disturbance in the diabetic SAS patients was not severe, it is unlikely that the pathogenesis of SAS with diabetes mellitus was due to severe autonomic disturbance derived from diabetic metabolic disturbance. The results of this study indicate that there is a close relationship between diabetes mellitus and SAS.View full abstractDownload PDF (1041K) -
Gen Yoshino, Tsutomu Kazumi, Masahide Iwai, Ippei Iwatani, Rinzo Uenoy ...1988 Volume 31 Issue 5 Pages 385-391
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCS-514 is one of the newly introduced inhibitors of endogenous cholesterol biosynthesis. In this study we determined the effect of this drug on plasma lipids, lipoprotein composition and glucose metabolism in 13 diabetics with elevated plasma cholesterol level. No serious adverse effects were noted on hematopoietic, hepatic or renal function in any of the patients after administration of 10 to 30 mg daily of CS-514 for 6 months. Plasma cholesterol, triglyceride and phospholipid were decreased from the first month. The three lipids in very low density lipoprotein (VLDL) and low density lipoprotein (LDL) also decreased simultaneously. High density lipoprotin (HDL)-cholesterol level was elevated at the first month but returned to the initial level after 6 months. There were no significant changes during the study period in the lipid per lipid ratio of any lipoprotein fraction, cholesterol per apo A-I or apo A-II in HDL or cubic root of plasma triglyceride per square root of apo C-II. Blood glucose, hemoglobin A1C and insulin response to an oral glucos load did not change at all after CS-514 treatment, suggesting no serious adverse effect of this drug on glucose metabolism in humans. Thus, CS-514 can be a useful agent for the treatment of hypercholesterolemia associated with diabetes mellitus.View full abstractDownload PDF (921K) -
Kenji Takahashi, Masahiko Sawahara, Satoru Okazaki, Tetsuya Fukuda, Ta ...1988 Volume 31 Issue 5 Pages 393-399
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCross-species reactivity of islet cell cytoplasmic antibodies (ICA) sera from patients with Type 1 (insulin-dependent) diabetes mellitus was investigated by using pancreases of various species.
Thirteen ICA-positive sera detected with human blood type 0 pancreas tissue were reacted with tissue sections of Sprague-Dawley rat pancreas, C3H mouse pancreas and Brockmann's corpuscle of yellowtail fish by the indirect immunofluorescence technique. The ICA titer was defined as the highest dilution of serum causing fluorescence of the islet. Spearman's rank correlation coefficient (rs) was used for statistical evaluation of the results.
Significant correlations were found between ICA titers in human pancreas and those in rat (rs=0.956, p<0.001) and mouse (rs=0.676, p<0.05) pancreas, but not between the ICA titer in human pancreas and grades of fluorescence intensity in Brockmann's corpuscle.
It was concluded that the antigens with which ICA reacts are species-nonspecific and that ICA can be detected clinically by using rat pancreas as a substitute for human pancreas. Furthermore, it was considered that target antigen proteins of rat islet cells reacting with ICA should be investigated for analysis of the immunopathogenesis of Type 1 diabetes mellitus.View full abstractDownload PDF (3572K) -
Yasuhiro Yamaguchi, Yoshiaki Kumamoto, Masaharu Aoki, Yoshikazu Satoh, ...1988 Volume 31 Issue 5 Pages 401-406
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSince the main etiologic factor of diabetic impotence (IMP) is said to be neurogenic, electrophysiological assessment is necessary when we deal with this condition. We measured the conduction velocity of the penile dorsal nerve (PDNV) and the conduction time of the bulbocavernosus reflex (BCRL) in 9 diabetics without IMP and 30 diabetics with IMP which was subdivided according to the decrease in the extent of erection into types I (11), II (6) and III (13).
BCRL was not prolonged in the non-IMP group, but was prolonged in the IMP group, i.e., in 9%, 40% and 40% of the type I, II and III subgroups, respectively. PDNV was decreased in 11.1% of the non-IMP group, and in 36.4%, 50% and 69.2% of the type I, II and III subgroups of IMP, respectively. Penile neuropathy not found by the determination of BCRL was detected by PDNV determination at a high incidence with increase in the severity of IMP.
Furthermore, to ascertain the relationship between PDNV and erectile potency, nocturnal penile tumescence (NPT) studies were performed on most patients. PDNV was significantly slower in patients whose penile circumference during NPT was below 10 mm than in those in whom it was above 20 mm. The finding led to the conclusion that measurement of PDNV as well as BCRL may be useful in diagnosing erectile neuropathy in dibetic patients.View full abstractDownload PDF (967K) -
Yasuo Morimoto, Hiroshi Taniguchi, Yuki Yamashiro, Kazushige Ejiri, Sh ...1988 Volume 31 Issue 5 Pages 407-412
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe association of the complement system with the development of complications in non-insulindependent diabetes mellitus (NIDDM) was evaluated by measuring various components of the complements system. CH 50, C 3 and C 4 were significantly elevated in patients with NIDDMs as compared with healthy subjects. However, there was no difference in CH 50 and C 3 between diabetic retinopathy and neuropathy. C 4 was higher in diabetics with retinopathy/neuropathy than in diabetics without these complications. ACH 50 and C 3 d were similar in NIDDMs and healthy subjects, and were not associated with complications of NIDDM. C 3 d/C 3 in frank NIDDM was lower than in healthy subjects, but there was no significant difference between the type of complications.
Thus, NIDDM was revealed to have high levels of complements. These observations suggested that NIDDM might be associated with the classical pathway rather than the alternative pathway.View full abstractDownload PDF (4693K) -
Retrospective and Prospective Analyses in Renal Transplant RecipientsEiichi Imano, Makoto Nomura, Kazuo Bando, Ryuzo Kawamori, Motoaki Shic ...1988 Volume 31 Issue 5 Pages 413-419
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo investigate the effect of Cyclosporin A (CsA) on pancreatic β cell function, we performed retrospective and prospective studies in renal transplant recipients (n=10). In these patiens, CsA was administered at a dose of 6-8mg/kg/day after operation.
In the retrospective study, 4 renal transplant recipients who developed diabetes mellitus after operation were investigated (diabetic group), and it was revealed that the mean trough level of CsA was elevated to 248±97 ng/ml.
In the prospective study, in which 6 patients were investigated, trough levels of CsA were frequently monitored in an attempt to maintain a level of 100 to 200 ng/ml by changing the administered dose. Oral glucose tolerance test (75 g), intravenous glucose tolerance test (0.3 g/kg), and intravenous glucagon loading test (1 mg) were carried out before, and 2 weeks and 6 weeks after operation in each patient. Thee were no significant changes in glucose tolerance and endogenous insulin secretory capacity before and after operation, and no patients developed diabetes mellitus after operation (non-diabetic group). In this group, the mean trough level of CsA was maintained at 119±44 ng/ml. There were no significant differences in prednisolone and CsA doses between the diabetic and non-diabetic groups.
This study suggested that CsA at a high serum concentration and with simultaneously administered corticosteroid might be toxic to pancreatic β cells. Thus, frequent monitoring of CsA levels might be beneficial in preventing this adverse effect of CsA on pancreatic β cells.View full abstractDownload PDF (1079K) -
Kenshi Yao, Toshika Otani, Tomonori Komori, Tadasu Kasahara, Atsushi K ...1988 Volume 31 Issue 5 Pages 421-425
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe eperienced a pair of identical twins who developed IDDM (insulin-dependent diabetes mellitus) on the same day. Among their family members, the maternal uncle had non-insulin-dependent diabetes. In previous reports we were not able to find a pair of twins whose clinical onset was on the same day. Both twins had HLA-A 2, A 24, B 38, Bw 54, Cw 3, DR 4, DRw 9, a typical type of Japanese IDDM. Their HLA type was thought to be one of the risk factors for IDDM.
They developed diabetes on the second day of school excursion. It was thought that the main factor leading to diabetes on the same day was their drinking a lot of juice and eating many sweets during the school excursion.View full abstractDownload PDF (728K) -
Takando Fujii, Shuji Inoue, Katsuaki Tanaka, Hajime Nagase, Atsushi Ok ...1988 Volume 31 Issue 5 Pages 427-429
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo investigate the role of the suprachiasmatic nucleus (SCN) in glucose homeostasis, the effects of electrical stimuration of the SCN on glucose metabolism were examined in female SD rats. Electrical stimulation caused hyperglycemia associated with elevation of plasma glucagon and no change of plasma insulin levels. These findings suggest that stimulation of SCN may produce hyperglycemia by facilitating glucagon secretion.View full abstractDownload PDF (370K) -
1988 Volume 31 Issue 5 Pages 431-435
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1056K) -
1988 Volume 31 Issue 5 Pages 437-455
Published: May 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (4746K)
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