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Volume 32, Issue 7
Displaying 1-11 of 11 articles from this issue
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Motoaki Shichiri1989 Volume 32 Issue 7 Pages 491-495
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (994K) -
Masanori Wakisaka, Shigeki Nagamachi, Kenjiro Inoue, Yasuyuki Morotomi ...1989 Volume 32 Issue 7 Pages 497-501
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSN-Isopropyl-123I-p-iodoamphetamine (IMP) was used to determine the regional cerebral blood flow in 9 diabetic patients (average age: 71.8 years) and 9 non-diabetic subjects (average age: 71.7 years), none of whom had a history of cerebrovascular accident. There were no significant differences in the physiological or laboratory data between the diabetic and non-diabetic groups except in fasting plasma glucose and HbA1c levels. Areas of hypoperfusion of the cerebral hemispheres were observed in 7 diabetic patients, 5 of whom showed multiple lesions. On the other hand, areas of hypoperfusion were observed only in 4 of the non-diabetic subjects and only 1 of these demonstrated multiple lesions. We evaluated the cerebral blood flow semiquantitatively as follows: the area where the radioactive count was 65% or more of the maximum count of the slice was defined as a region of normal cerebral blood flow (ROI-A) the area where the count was 45% or more as region of brain tissue except for ventricles (RUT-B). The numbers of pixels of ROI-A and ROI-B were counted in each slice and the ROI-A/B ratios of 16 slices were averaged individually. The average percent ROI-A/B ratio was significantly lower in the diabetic group than that in the control group, (49.4±1.9 (Mean±SEM) vs 56.6±1.9%, p<0.05) These observations suggest that the area of normal regional cerebral blood flow is reduced in aged diabetics, even in the absence of a history of cerebrovascular accident. J. Japan Diab. Soc. 32 (7): 497-501, 1989View full abstractDownload PDF (3004K) -
Kazumasa Igarashi1989 Volume 32 Issue 7 Pages 503-510
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to evaluate diabetic nephropathy, five proteins with different molecular weights and isoelectric points were measured by RIA in urine samples of controls and diabetic patients without clinical nephropathy after water loading test. The degree of diabetic nephropathy was divided into three groups according to the maximum urinary albumin excretion rate (U-AERmax) after water loading test: group 1 (U-AERmax <15μg/min), group 2 (15-100μg/min), and group 3 (>100μg/min).
The ratio of orosomucoid to U-AERmax in group 1 was significantly higher than that in the control sample, though the ratio of lambda free light chain to U-AERmax was not significant in either group. The results suggest that the charge selectivity loss of the glomerular basement membrane (GBM) may occur in the group 1stage, because orosomucoid and lambda free light chain have similar molecular weights with different isoelectric points. Furthermore, the leakage of IgG, which has a large molecular weight, was significantly increased in group 3. This result indicates that pore size selectivity loss in the GBM may exist in group 3. These findings suggest that the water loading test might be useful in analyzing the severity of diabetic nephropathy.View full abstractDownload PDF (1517K) -
S Okada, Y Miyai, Y Masaki, K Sato, T Higuchi, Y Ogino, K Ichiki, S Ta ...1989 Volume 32 Issue 7 Pages 511-515
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA study was undertaken to ascertain the validity of Teuscher's method for measuring the increase in knowledge of the disease gained by patients with diabetes after training. An investigation was carried out on the correlation between the increase in knowledge obtained with diabetes training (ΔK) and the decrease in HbA1 (ΔHbA1) in a group of diabetic patients who were given information concerning their disease. This series comprised ambulatory non-insulin-dependent diabetics without insulin or oral agents (N=79), 26 in the high socioeconomic stratum (Stratum A) and 53 in the middle or low socioeconomic stratum (Stratum B). Diabetes training resulted in an increase in the number of correct answers to questions from 12.6±4.8 to 17.2±1.6 (p<0.001) in Stratum A and from 11.1±3.8 to 15.9±2.6 (p<0.001) in Stratum B, with the HbA1 value decreasing from 10.5±1.5% to 9.4±1.8%(p<0.05) in stratum A and from 11.3±2.3% to 9.7±1.9%(p< 0.001) in Stratum B. Thus, a positive correlation was noted between AK and AHbA, in Stratum A (n=16, r=0.57, p<0.05, Spearman's rank correlation test), whereas no such distinct correlation was observed in Stratum B. In control groups which did not take part in the teaching program, no significant change in these parameters was noted during the 2-month observation period. These results indicate that Teuscher's method is valid and useful as a means of measuring the increase in knowledge of disease acquired by patients with diabetes after training.View full abstractDownload PDF (640K) -
Immunologic AspectsYutaka Mori, Junichi Yokoyama, Akira Tsuruoka, Hideaki Kurata, Junko M ...1989 Volume 32 Issue 7 Pages 517-523
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined some immunological abnormalities in order to clarify the pathogenesis of WBN/Kob rats. In male rats, leukocytosis was observed at the age of 3 to 5 weeks and continued to be observed until 15 to 24 months of age. Leukocytosis however, was not observed in the female rat population. Regarding T cell subset, the absolute numbers of R1-3B3+ cells (pan T), OX19+cells (pan T), RTH-7+cells (helper/inducer T) and R1-10B5+ (suppressor/cytotoxic T), were significantly decreased in both male and female WBN/ Kob rats in comparison with Wistar rats. Although ICA was not detected, the sera of WBN/Kob rats revealed significantly higher titer of anti-insulin antibody in comparison with Wistar rats. In conclusion, leukocytosis. a remarkable T cell lymphopenia in the peripheral blood, and a higher titer of insulin antibody in the sera were observed in WBN/Kob rats. The relationship between these immunological abnormalities and the etiopathogenesis of endo-exocrine pancreatic impairment in this rat is unclear. Nevertheless, the new diabetic strain of WBN/Kob rats is valuable for studies on endo-exocrine pancreatic insufficiency.View full abstractDownload PDF (2283K) -
Shuichi Okada, Kihachi Ohshima1989 Volume 32 Issue 7 Pages 525-531
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe hypothesis that insulin resistance in obesity results from a reduction in glucose transport activity was tested studying obese female ddymice six weeks after the administration of gold thioglucose (GTG 800 mg/kg). Glucose uptake was studied by measuring the 2-deoxyglucosephosphate (2 DGP) accumulation after tritiumlabeled 2 DG infusion in lean and in obese mice, in both the basal and the insulin-stimulated states, using a perfused hindquarter preparation. Hexokinase activity in a skeletal muscle from the hindquarter was also studied by measuring the nicotinamideadenosine dinucleotide phosphate, (NADPH), production using the method of Berger. The 2 DGP accumulation rate in obese mice was significantly reduced not only in the insulin-stimulated state but also in the basal state. 2 DGP is not metabolised further, so a reduced 2 DGP accumulation suggest that the glucose transport activity or the hexokinase activity is reduced in the obese mice. Contrary to the 2 DGP accumulation, the hexokinase activity of obese mice did not differ from that of lean mice (lean: 5.0±1.1μmol/min/mg protein, obese: 5.2±0.2μmol/min/mg protein). These results suggest that reduced glucose transport activity plays a role in insulin resistance in the skeletal muscle of gold thioglucose-induced obese mice.View full abstractDownload PDF (1383K) -
Izumi Nashimoto1989 Volume 32 Issue 7 Pages 533-539
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe urinary excretion rate of glycosaminoglycans (GAGs) was measured in timed-overnight urine samples from 154 non-insulin dependent diabetics (NIDDM) without overt diabetic nephropathy, and in those of 45 normal controls, using the dye-binding method of Alcian-blue 8GX. Albumin excretion rate (AER) was also measured in the same samples. The GAGs excretion rate in NIDDM was significantly higher than in the controls (p<0.005). In microalbuminuric patients (20<AER<200μg/min), GAGs excretion was significantly higher than in normoalbuminuric patients (AER<20μg/min). GAGs excretion rate did not correlate with diabetic duration, Hb Ai c levels, and blood pressure, however it directly correlated with creatinin clearance in normoalbuminuric patients without retinopathy. GAGs excretion in normoalbuminuric patients with proliferative relinopathy was significantly higer than that in normoalbuminuric patients with other stages of diabetic retinopathy (p<0.001). These results suggest that an abnomal metabolism of GAGs occurred in NIDDM with microangiopathy, and that an increase in GAGs excretion in microalbuminuric patients might reflect a reduction of anionic charge in the glomerular basement membrane. Further study is required to determine the effect of long-term metabolic control on GAGs excretion.View full abstractDownload PDF (1234K) -
Naoko Kumagai, Hikaru Sagara, Yoshiko Hayashida, Hideki Hayashi, Shinj ...1989 Volume 32 Issue 7 Pages 541-546
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 43-year-old female was admitted to this Department of Medicine in 1985 with suspected insulinoma. In 1974, at the age of 31 years, she had experienced an episode of unconsciousness during the third month of pregnancy, and laboratory data at that time suggested a diagnosis of insulinoma. Selective angiography however, demonstrated no mass lesion. This patient had been hospitalized with dementia, by the Department of Neuropsychiatry and the repeated consumption of carbohydrates to prevent hypoglycemic attacks, had resulted in marked obesity, (+83% by Jones' method). In 1985, a series of laboratory tests, including repeatedly determined plasma glucose and insulin levels, glucagon testing, fasting tests, selective angiography, abdominal ultrasonography, and percutaneous transhepatic portal vein catheterization, suggested the presence of a functioning insulinoma in the body of the pancreas. Subsequently, a globular tumor of 12mm in diameter was removed successfully, and this resulted in an almost perfect correction of obesity in approximately 6 months. Computerized tomography (CT) of the patient's brain revealed considerable atrophy mainly in the cerebral cortex ; finding which has been rarely documented in the literature.View full abstractDownload PDF (5059K) -
Masaki Amenomori, Itsurou Nishigaki, Kenji Ogino, Shigeo Yamashita, Mi ...1989 Volume 32 Issue 7 Pages 547-551
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 44-year-old man with diabetic ketoacidosis was treated with continuous subcutaneous insulin injection. On the fifth day, of hospitalization multiple red papules accompanied by severe pruritus, developed on the abdomen, face and extremities. The papules on the face and extremities disappeared leaving marked brownish pigmentation, as the patient's blood sugar level was controlled. Based on the specific clinical features and the histology of the lesions, a diagnosis of prurigo pigmentosa, was derermined. Prurigo pigmentosa is a rare inflammatory skin disease, that has been mainly reported in Japan. As there has been to date no report of prurigo pigmentosa associated with insulin-dependent diabetes mellitus, this case was considered very rare.View full abstractDownload PDF (3044K) -
Toshika Otani, Hiroki Yokoyama, Yasuko Uchigata, Yuko Higami, Tadasu K ...1989 Volume 32 Issue 7 Pages 553-555
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSHLA-DR typing was performed in 25 Japanese patients with maturity-onset type diabetes of young people (MODY), 486 healthy randomly selected subjects and 94 patients with insulin-dependent diabetes mellitus (IDDM). No significant differences in HLA-DR were noted between Japanese MODY and healthy Japanese controls, which is exactly the same results observed among Caucasians. Compared with MODY and healthy Japanese controls, the frequency of DR 2 in IDDM patients was significantly decreased, while, the frequencies of DR4 and DR9 were significantly high. These finding suggest that HLA-DR types are not related to MODY.View full abstractDownload PDF (357K) -
1989 Volume 32 Issue 7 Pages 557-564
Published: July 30, 1989
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1562K)
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