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Volume 31, Issue 9
Displaying 1-10 of 10 articles from this issue
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[in Japanese]1988 Volume 31 Issue 9 Pages 721-724
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese]1988 Volume 31 Issue 9 Pages 725-728
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
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[in Japanese]1988 Volume 31 Issue 9 Pages 729-731
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
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Changes in Insulin Sensitivity in Adrenal Demedullated RatsSetsuro Okada, Yuzo Sato, Chikashi Yamamoto, Yoshiharu Oshida, Akihisa ...1988 Volume 31 Issue 9 Pages 733-737
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe purpose of this study was to determine the influence of epinephrine on the improvement of insulin sensitivity after long-term physical training.
The euglycemic insulin clamp technique was performed in adrenodemedullated trained rats (ADMX-T group, running over 5, 000m/day for 4wk), adrenodemedullated sedentary rats (ADMX group), sham-operated trained rats (SHAM-T group), and control rats (CT group). The insulin infusion rates were 4.4, 8.8 and 29.2mU/kg/min. The plasma glucose concentration was maintained constant at basal preinfusion levels by the periodic adjustment of a variable amount of glucose infusion, and glucose metabolism (GM) was determined.
The following results were obtained.
1. The more the insulin infusion rate increased, the more GM increased.
2. Under the condition of physiological hyperinsulinemia, the GM of ADMX-T, ADMX and SHAM-T were significantly higher (respectively 92%, 42%, 37%) than that of CT.
The results suggest that epinephrine is a negative factor in increased insulin sensitivity after physical training.View full abstractDownload PDF (690K) -
Takeshi Mizobuchi, Mitsuhiro Matsumura1988 Volume 31 Issue 9 Pages 739-744
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo study the release of β-endorphin-like immunoreactivity (β-EpLI) in diabetes mellitus, two groups of diabetic rats were prepared by administration of 30 or 60mg/kg body weight of streptozotocin (STZ). Concentrations of insulin and β-EpLI in portal plasma and various tissues were measured in these rats, and the following results were obtained.
1. Concentrations of β-EpLI in portal plasma and pancreatic tissues of both groups of STZ-induced diabetic rats were significantly increased as compared with those of the control group.
2. Concentrations of β-EpLI in the pituitary tissues of both groups of STZ-induced diabetic rats did not change significantly as compared with those of the control group.
3. Portal plasma levels of β-EpLI and the concentration of β-EpLI in the pancreatic tissue of diabetic rats (60mg/kg body weight) given lente insulin every day differed little from those of the control group.
These results suggested that the pancreas might participate, at least partly, in the increase of β-EpLI release in STZ-induced diabetic rats. Furthermore, from the observations that portal plasma levels of β-EpLI in STZ-induced diabetic rats given lente insulin for seven days were similar with those of the control group, it was considered that increases of portal plasma β-EpLI in rats with STZ-induced diabetes were due to insulin deficiency.View full abstractDownload PDF (932K) -
Eisuke Takazakura, Kenzou Ohsawa, Yasuhito Terada, Hiroshi Makino, Hir ...1988 Volume 31 Issue 9 Pages 745-751
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSixteen cases of refractory diabetic gangrene were successfully treated by a new combination therapy: continuous intra-arterial infusion of prostaglandin E1 (PGE1) insulin and heparin solution (PIH therapy). Angiography revealed arteriosclerosis obliterans (ASO) in three of the cases. PIH solution was infused, by means of a portable infusion pump, through a catheter placed in the femoral artery, at the following doses: PGE1 0.15 ng/kg/min. Actrapid insulin 10 U/day, heparin 100 U/day. In all 13 patients without ASO, the gangrene was healed completely in 21 to 120 days (averge 58.6 days), whereas among the three diabetics with ASO, it was healed in only one case and amputation was performed on the other two cases. All healed patients revealed positive RI accumulation in the wound on a 99mTC-MAA perfusion scan and elevation of deep skin temperature by 3° to 7°C after the beginnig of PIH therapy, while in the two patients who did not respond to PIH both tests were negative.
PIH therapy is indicated as a new method of treatment for diabetic gangrene intractable to conventional treatment. Positive RI accumulation and an elevation of deep skin temperature in the wound suggest a high possibility of healing gangrene with PIH therapy.View full abstractDownload PDF (2656K) -
Akira Sasaki, Masuko Uehara1988 Volume 31 Issue 9 Pages 753-760
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 23, 577 death certificates mentioning diabetes, 10, 927 as the underlying cause and 12, 650 as a contributory condition, which were filed in Osaka, Japan, during a 25-year period between 1960 and 1984, were analyzed, using the multiple coding method.
1) The ratio of death certificates mentioning diabetes, which was only 0.9% of all causes of death in 1960-1964, rapidly increased to 3.5% in 1980-1984. Among diabetics, the ratio of patients aged 65-years or over increased markedly duing the same period, from 47.2% to 68.8%.
2) On the other hand, the ratio of diabetes as the underlying cause among certificates mentioning diabetes decreased drastically, from 57.7% in 1960-1964 to 36.8% in 1980-1984.
3) Remarkable changes in the underlying causes of death among diabetics were observed during the study period: an increase in disease of the circulatory system, especially heart disease, which exceeded cerebrovascular disease in 1980-1984.
4) An increase in diabetic nephropathy, which had not been analyzed previously since it was reported as a contributory condition, was also confirmed using the multiple coding method employed here.View full abstractDownload PDF (2593K) -
Yuki Yamashiro, Hiroshi Taniguchi, Shigeaki Baba1988 Volume 31 Issue 9 Pages 761-766
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe target antigens of islet cell antibodies (ICA) have not been identified. We tried to modify the antigenic structure of islet cells and to see if there were changes in the immunohistochemical reaction of ICA-positive sera with them.
Human pancreatic tissues were treated with periodate, borohydride, neuraminidase, methanol, chloroform-methanol or protease for modification of their antigens. The treated tissues were subjected to immunohistochemical staining with ICA-positive sera.
Two types of ICAs were observed, one probably reacting with the sialic acid residue of glycolipid and the other with protein. Patients with the latter ICA were found to have a longer duration of diabetes than those with the former type.
The results suggested that there are at least two types of ICAs which recognize different antigens, and that this difference might be related to the duration of diabetes.View full abstractDownload PDF (2668K) -
Takashi Nagai, Yasumasa Yoshie, Takashi Tomizawa, Setsuo Kobayashi1988 Volume 31 Issue 9 Pages 767-772
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a diabetic patient with xanthogranulomatous perinephric abscess. A 56-year-old woman with uncontrolled diabetes mellitus of 3 years' duration was admitted to our hospital for treatment of a sense of thirst, lumbago and fever. She had often been treated for urinary tract infections. Physical examination disclosed bilateral back pain and a right lumbar hard tumor with tenderness. Urinalysis showed pyuria and leucocyte casts. A specimen of urine obtained by catheter yielded E. coil on culture. Fasting blood glucose was 290 mg/dl, glycohemoglobin A1 13.5%, total cholesterol 177 mg/dl, and triglyceride 193 mg/dl. Renal echography demonstrated a right perinephric mass lesion. After control of diabetes mellitus and inflammation by transfusion, insulin therapy and antibiotics, the mass lesion was drained surgically. Histopathological examination revealed xanthogranulomatous perinephric abscess. We discuss the association between xanthogranulomatous perinephric abscess and diabetes mellitus and consider that good control of diabetes mellitus and early and accurate chemotherapy prevents this condition.View full abstractDownload PDF (4523K) -
1988 Volume 31 Issue 9 Pages 773-778
Published: September 30, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1329K)
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