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Volume 40, Issue 3
Displaying 1-6 of 6 articles from this issue
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Kazuhiro Matsumura, Hideto Kojima, Hideki Hidaka, Ryuichi Kikkawa1997 Volume 40 Issue 3 Pages 147-154
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe roles of insulin-like growth factor I (IGF-I) and hyperglycemia in the development of gut hyperplasia, which was found in insulin-deficient animals, were studied. Ornithine decarboxylase (ODC), a rate-limiting enzyme in the de novo synthesis of polyamines, has important regulatory roles in epithelial cell proliferation in the small intestine. In IEC-6 cells, a model epithelial cell line, IGF-I (100 nM) stimulated ODC mRNA expression six fold, ODC enzyme activity 19-fold, and [3H] thymidine incorporation rates four fold as compared with the control. The IGF-I-induced stimulation of [3H] thymidine incorporation was inhibited by the simultaneous addition of difluoromethylornithine (DFMO; 5 mM) and this DFMO-induced inhibition was abolished by treatment with 10 μM putrescine. Moreover, the IGF-I-induced ODC enzyme activation was totally prevented by treatment with actinomycin D (4 μM), suggesting the importance of ODC mRNA expression in cell proliferation induced by IGF-I. Furthermore, increased concentrations of glucose in the culture medium had an additive effect on IGF-I-stimulated ODC activation and [3H] thymidine incorporation in IEC-6 cells. Since the increased glucose concentration in the culture medium had no effect on ODC mRNA expression with or without IGF-I, its effect on ODC activity was induced through post-transcriptional control. These results suggest that IGF-I and hyperglycemia may play important roles in the small intestinal hyperplasia in insulin-deficient diabetic animals.View full abstractDownload PDF (2710K) -
Part II Changes in Dental Condition during Ten Years in NIDDM PatientsTeiji Shibasaki, Seiichiro Saito, Tomohiro Kasuya, Sonoko Anazawa, Yos ...1997 Volume 40 Issue 3 Pages 155-163
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe purpose of this study was to investigate the effects of good and poor control of NIDDM on teeth and periodental conditions. Thirty-four NIDDM patients who underwent dental examination in 1982 were followed up for ten years. These patients (males, 19; females, 15; age, 50-69yr. in 1992) were divided into a good control group (group A, HbA1c< 8.0, n=14) and a poor control group (group B HbA1c≤8.0, n=20) according to the mean HbA1c for ten years. The duration of diabetes in group B was significantly longer than in group A. Many more decayed teeth and missing teeth were observed in group B than in group A at examinations in both 1982 and 1992. The number of missing teeth increased significnantly in both groups during ten years and the mean number of teeth lost in group B (3.9) was greater than in group A (1.6). Gingivitis and alveolar bone resorption in group B were also severer than in group A at both examinations. During ten years, gingivitis improved equally in two groups. However, alveolar bone resorption and periodontal pockets increased equally in the two groups. We conclude that diabetes should be controlled properly in order to maintain good dental conditions, and dental examination should be performed at the onset of NIDDM and periodically thereafter, because the dental condition seems to be related to the control and duration of NIDDM.View full abstractDownload PDF (1213K) -
Ken Sato, Hiroki Yokoyama, Masanobu Takeda, Osamu Tomonaga, Chieko Tak ...1997 Volume 40 Issue 3 Pages 165-170
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSCharge selectivity and size selectivity were assessed by the clearance ratio of IgG and IgG4, which are the same in molecular weight but different in electronic charge. The subjects were 32 NIDDM patients, 14 males and 18 females, with normoalbuminuria (n=14), incipient nephropathy (n =12) and overt nephropathy (n=6). Timed urine samples were collected in the morning, during exercise of 1h walking, in the afternoon, and during overnight sleep. The urinary albumin excretion rate (AER) and serum and urinary concentrations ofβ2 microglobulin (βMG), IgG and IgG4 were measured and the selectivity index (SI) was calculated by the IgG/IgG4 clearance. The ratio AER was divided into normoalbuminuric (A0, AER <20), microalbuminuric (Al, AER 20-200), and macroalbuminuric (A2, AER > 200). IgG clearance was higher in A2 than in Al and A0. SI was significantly lower in Al than in A0, and was even lower in A2 than in Al. No difference was found in βMG clearance between the groups. Also there were no differences in AER and SI among different timed-urine samples. The study may indicate that loss of charge selectivity precedes loss of size selectivity in diabetic nephropathy.View full abstractDownload PDF (789K) -
1997 Volume 40 Issue 3 Pages 171-180
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
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1997 Volume 40 Issue 3 Pages 181-202
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1997 Volume 40 Issue 3 Pages 203-210
Published: March 30, 1997
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (1667K)
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