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Volume 37, Issue 11
Displaying 1-10 of 10 articles from this issue
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Mitsuru Hoshi, Tadashi Takimoto, Yasuo Tano, Yoshihiro Saito1994 Volume 37 Issue 11 Pages 791-801
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (4280K) -
Mikiko Kawaguchi, Keiichiro Tanigawa, Yuzuru Kato1994 Volume 37 Issue 11 Pages 803-809
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effect of maternal heat stress on embryogenesis in the rat was examined. On day 10.5 post-conception, normal dams (n=8) and the streptozotocin-induced diabetic dams (n=9) were exposed to heat shock (rectal temperature of 41°C for 5min). Control dams (normal dams: n=8, diabetic dams: n=8) were restrained in a similar manner at room temperature. On day 11.6 of gestation, total number of somites (SN), crown-rump length (CRL), total protein (TP) and DNA content were measured in each embryo. Heat stress did not affect the SN, CRL or TP of the embryas of normal dams, but their DNA levels were significantly reduced (32.3±0.6vs. 30.0±0.5μg, p<0.05). The total DNA content of embryos of diabetic dams was lower than in the control embryos and was further reduced by heat stress (27.3±0.6vs. 24.0±0.5μg, p<0.05). The incidence Of anomalies in the embryos of diabetic rats was slightly but not significantly greater than in the embryos of non-diabetic rats, but unaffected by heat stress. These findings suggest that prevention of embryo cell proliferation during organogenesis is not directly linked to teratogenesis.View full abstractDownload PDF (3893K) -
Mototaka Yoshinari, Yasufumi Doi, Kenzou Iino, Misao Yamamoto, Noriyas ...1994 Volume 37 Issue 11 Pages 811-818
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSAlthough the treatment of hyperglycemia reduces the serum lipid level, moderately controlled diabetics are known to have dyslipidemia. To study the prevalence of hyperlipidemia in moderately well controlled NIDDM, serum lipid levels were measured in 680 NIDDM outpatients who visited 22 clinics in Fukuoka prefecture during the last week of January, 1993. Their mean hemoglobin Ai c level was 7.3±1.5%(SD). The prevalence of hyperlipidemia (total cholesterol>220mg/dl and/ or triglyceride>150mg/dl) was 52% when the patients treated with lipid-lowering drugs were included. Drugs, 74% of which were a HMGCoA reductase inhibitor, were given to 32% of the hyperlipidemics. Alcohol intake decreased the total cholesterol level, but more than 30g/day increased triglyceride levels.
In conclusion, 48% of NIDDMs under moderate glycemic control had hypercholesterolemia. Lipid lowering drugs were administrated to 32% of hyperlipidemics and reduced the prevalence of hypercholesterolemia to 32% of the total. Alcohol intake of less than 30 g/day may be allowed to reduce hyperlipidemia in these NIDDM patients.View full abstractDownload PDF (1295K) -
Takeshi Osonoi, Yoshihiro Fukumoto, Tomio Onuma, Miyoko Saitou, Yasuhi ...1994 Volume 37 Issue 11 Pages 819-825
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSSingle-photon emission computed tomography was performed in 52 diabetics and 10 healthy volunteers using MIBG. The diabetics had no particular findings of electrocardiography, echocardiography, or exercise thallium imaging and no cardiovascular episodes. The healthy volunteers had no abnormal findings on exercise thallium imaging or glucose tolerance test. The average relative regional uptake (RRU) was decreased in the inferoposterior wall compared with the anterior or lateral wall in both the diabetics and volunteers. According to the RRU and visual images, we divided the diabetics into the following four groups: 14 who were normal (group N), 30 with segmental defects (group S), 4 with diffuse defects (group D) and 4 without accumulation (group DH). Diabetic complications (retinopathy, nephropathy, and neuropathy) and hypertension were more frequent in group S than group N. However, there were no significant differences in the physiological evidence of autonomic neuropathy (C. V. of the R-R interval on the ECG and blood pressure response to standing or deep breathing) between groups S and N. Vibration sense was significantly more impaired in group S than in group N. These results suggest that cardiac imaging with MIBG might be a useful examination for the early diagnosis of diabetic autonomic neuropathy.View full abstractDownload PDF (4737K) -
Yoshinori Ohtsuka, Noriyuki Yabunaka, Hiroshi Noro, Ichiro Watanabe, Y ...1994 Volume 37 Issue 11 Pages 827-832
Published: November 30, 1994
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSErythrocyte aldose reductase activity was measured in diabetic patients and normal controls. The enzyme activity was 2.07±0.14 (meas±SEM, U/gHb, n=45) and 1.11±0.12 (n=34) indiabetic patients and normal controls, respectively (p<0.0001). Activities of the enzyme correlated well with HbA1 (p<0.01) but not with fasting plasma glucose. To elucidate the effect of ambient temperature on erythrocyte aldose reductase activity, 9 male students were immersed in water at three different temperatures. After water immersion at 42°C for 10min, enzyme activity increased by 37.6%(p<0.01); however, this activity decreased after immersion for 10min at 39°C (-52.2%, p<0.01) and 25°C (-47.0%, p<0.05). Erythrocyte sorbitol content increased by 36.0%(p<0.05) after immersion at 42°C. These changes suggest that heat stress might have some effect on diabetic complications.View full abstractDownload PDF (695K) -
Kanako Otuka, Hisao Ito, Yoshiko Tokisawa, Masazumi Tanaka, Naoki Hach ...1994 Volume 37 Issue 11 Pages 833-837
Published: November 30, 1994
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSA 54-year-old woman was diagnosed with idiopathic thrombocytopenic purpura (ITP) in 1968, rheumatoid arthritis (RA) in 1971, and non insulin-dependent diabetes mellitus (NIDDM) in 1985. She was admitted with hyperglycemia and ketosis, because blood sugar control of NIDDM with urine c-peptide of 36ug per day had gradually become unstable since 1989. On admission, chemical studies of her diabetes mellitus showed less than 10ug per day of urine c-peptide and no response to the glucagon test. She had also experienced 6 abortions and premature births. Laboratory data showed positive findings of islet cell antibody, antiplatelet antibody, rheumatoid factor, and lupus anticoagulant. A diagnosis of antiphospholipid (aPL) syndrome was made on the basis of laboratory data and past history. Non Insulin-dependent dabetes melltus with aPL syndrome, ITP and RA resulted slowly progressive IDDM. The dose of glucocorticoid was increased, and she received intensive conventional insulin therapy. This case is very interesting in regard to the mechanisms of onset of serial autoimmune diseases.View full abstractDownload PDF (746K) -
Tokue Katori, Yoshiaki Hashimoto, Tokiharu Takahashi, Hiroko Teratani, ...1994 Volume 37 Issue 11 Pages 839-844
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 56-year-old man was admitted for evaluation of progressive postprandial hypoglycemia over a ten-year period. The high concentration of fastirlg plasma ilnmuoreactive insulirl (80μU/ml) with 34mg/dl of plasma glucose (PG), even though without hypoglycemic symptoms, suggested the presence of insulinoma. Excessive insulin secretion was also observed after meals (2h after breakfast: insulin 307μU/ml, PG 118mg/dl). Oral and intravenous glucose tolerance tests and the glucagon test resulted in excessive insulin secretion with peaks of 1040μU/ml, >9999μU/ml and 2768μU/ml, respectively. PG concentrations duriag intravenous glucose tolerance and glucagon tests decreased to less than 30mg/dl. A fasting exercise test performed suppressed insulin secretion from 31μU/ml to 6μU/ml at 60min and fasting raised PG from 48mg/dl to 82mg/dl. A 2cm tumor in the head of the pancreas was removed and identified histologically as a benign insulin-secreting islet cell tumor.
In summary, we report a rare case of insulinoma characterized by excessive insulin secretion in response to glucose, and therefore, postprandial hypoglycemia.View full abstractDownload PDF (2705K) -
Fumiaki Kitamuro, Hirofumi Hayashi, Yasuko Uchigata1994 Volume 37 Issue 11 Pages 845-849
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA case of insulin autoimmune syndrome is reported. A 78-yr old man came to us complaining of cold sweats and palpitations around noontime for 2 months.
Fasting blood glucose was 53mg/dl, and fasting IRI determined by the double antibody method was 320μU/ml. He had never received insulin injections.
The percent 125 I-insulin binding was 70%, and a large amount of total IRI extracted by the acid ethanol method was observed.
This patient possessed HLA-DR4/DQ3 bearing DRB10403/DQA10301/DQB10302, whereas almost all patients with insulin autoimmune syndrome have been reported to possess HLA DR4/ DQ3 bearing DRB10406/DQA10301/DQB10302.View full abstractDownload PDF (611K) -
Masafumi Shigehira, Tetsu Kawano, Hirofumi Uto, Tetsufumi Nakama, Juny ...1994 Volume 37 Issue 11 Pages 851-854
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSWe investigated the retinal findngs in eleven patients with diabetes mellitus during interferon (IFN) therapy for chronic type C hepatitis. Fundic examinations were performed periodically before and at 1 week, 2 weeks and 4 weeks and every month after IFN therapy. In eight of nine patients (88.9%) free of diabetic retinopathy before IFN therapy, retinal abnormalities, dot or patchy hemorrhage and cotton-wool spots, developed during IFN therapy. In another two patients with diabetic retinopathy before IFN therapy, retinal hemorrhage worsened. Therefore, we considered that diabees mellitus was a risk factor for retinal abnormality during IFN therapy. Fortunately, these abnormalities were not severe and did not exacerbate during IFN treatment except for one patient with diabetic retinopathy before IFN therapy, whose visual acuity was impaired. Thus we should use IFN carefully for diabetic patients.View full abstractDownload PDF (2607K) -
A Report of the Committee on an Interlaboratory Standardization of HbA1c Determination, the Japan Diabetes SocietyKenji Shima, Jiro Endo, Munetada Oimomi, Ichiyo Oshima, Yasue Omori, Y ...1994 Volume 37 Issue 11 Pages 855-864
Published: November 30, 1994
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSOn the basis of the previous interim report of this committee, it became apparent that there was a big variation in the measured values of HbA1c among the participants and this large interlaboratory variation was mainly due to differences in evaluation of a labile HbA1c component and in values measured with an instrument of one manufacture and with the other. In the present study we investigated whether standardizing to measure only stable component using common calibrators was useful to reduce the large interlaboratory variation. If it is so, the reference intervals of HbA1c value will be established using the standardized procedure. The committee sent a set of materials (two lyophilized erythrocyte hemolysates, two similarly processed calibrators and each one of fresh blood samples obtained from a healthy person and a diabetic patient) to 110 institutes and asked to measure stable HbA1c percentage in the materials. To assign HbA1c percentages to calibrators, we used HbA1c results from 100 participants who sent us the data good enough to evaluate judgingc from their chromatograms. Two-point calibration with assigned values improved interlaboratory variation as follows; CV with and without calibration, lyophilized hemolysate 1. 1.98% and 5.33%, lyophilized hemolysate 2, 1.43% and 3.24%, normal fresh blood, 3.88% and 7.76%, and diabetic fresh blood, 2.82% and 3.53%.
We concluded that this standardized procedure i.e. measuring only stable HbA1c component and correcting the HbA1c percentages thus obtained with the assigned value of the calibrators, is useful to reduce the interlaboratory variation to the clinically desirable level of 4.0% which was calculated from data of the questionnaire to about 100 qualified diabetologists in Japan.
The reference intervals of HbA1c percentage calculated from HbA1c results of 725 healthy subjects measured using the standardized procedure was from 4.3% to 5.8%.View full abstractDownload PDF (1431K)
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