Journal of the Japan Diabetes Society

[title in Japanese]

S. Miyao

1968 Volume 11 Issue 1 Pages 1-6
Published: January 31, 1968
Released on J-STAGE: August 10, 2011

DOIhttps://doi.org/10.11213/tonyobyo1958.11.1

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Interrelationship between Glucose and Lipid Metabolism in Adipose Tissue of Rats Fed High Calorie Diet

Y. Shigeta, M. Kang, K. Izumi, M. Hoshi

1968 Volume 11 Issue 1 Pages 7-13
Published: January 31, 1968
Released on J-STAGE: August 10, 2011

DOIhttps://doi.org/10.11213/tonyobyo1958.11.7

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Interrelationship between glucose and lipid metabolism has been studied in rats fed high calorie diet (HCD rats) compared with rats fed control diet (CD rats), gluconeogenesis and lipogenesis of which have been previously reported by authers.
1) In vivo experiments:
The fasting blood sugar level of HCD rats was higher than that of CD rats and there was no significant difference between both K values after IVGTT. On the other hand the incorporation of glucose-6-¹⁴C into fatty acids was fortified in the carcass of HCD rats. In determining insulin like activity and NEFA, hyperinsulinism and high NEFA levels of serum and epididymal adipose tissue were seen in HCD rats.
2) In vitro experiments:
When the adipose tissue of HCD or CD rats was incubated with glucose-6-¹⁴C and insulin, it has been shown that the glucose uptake, incorporation of glucose-¹⁴C into fatty acids and NEFA release in HCD rats decreased, but the incorporation of glucose-¹⁴C into CO and glyceride glycerol and glycerol release in HCD rats did not decrease compared with that in CD rats. Also we found that epididymal adipose tissue was resistant to insulin response in HCD rats. re-esterification of NEFA.
These data suggest that glucose tolerance is not disturbed, but its hyper NEFA emia and hyperinsulinism cause the abnormal pattern of glucose metabolism in HCD rats, which accelerates obesity because of the
The difference between fatty acid synthesis from glucose in vivo and in vitro seems to be due to the total amount of adipose tissue.

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Incidence of Glycosuria and Diabetes Mellitus in Cases Exposed to the Atomic Bomb

Sunao Wada, Ryoso Kawate, Michio Yamakido, Yuji Nishiki, Chikako Ito, ...

1968 Volume 11 Issue 1 Pages 14-22
Published: January 31, 1968
Released on J-STAGE: August 10, 2011

DOIhttps://doi.org/10.11213/tonyobyo1958.11.14

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58, 235 subjects in 1963, 49, 174 subjects in 1964, 55, 393 subjects in 1965 and 82, 001 subjects in 1966 received a screening test for glycosuria using tes-tape. Since this study wes done on individuals who were exposed to the Atomic Bomb, no one was under 17 years of age when examined. Urine sample was obtained between 9 AM for 4 PM. Incidence of positive glycosuria was 3.0%, 3.9%, 4.4% and 4.3% respectively in each year. The incidence was 3.6 times higher in the male than in the female. Maxium incidence was noted in men over 60 years old being 10.1%, and minimum was in women under 39 years old being 1.1%. Of the glycosuric patients, 25.1% of males and 56.1% of females were obese, and 11.9% of males and 18.2% of females gave a family history of diabetes mellitus.
2, 352 subjects from the cases who showed positive glycosuria had an oral glucose tolerance test. It was positive for diabetes mellitus in 42.6% of the subjects, 28.6% showed possible diabetes mellitus, 5.4% showed oxyhyperglycemia, 0.9% showed renal glycosuria and 22.3% were normal. Detection ratio of diabetes mellitus from the glycosuric patients was higher in the female (55.2%) than in the male (37.7%), though incidence of glycosuria was higher in the male than in the female. Of the 21 subjects who were diagnosed as renal glycosuria, 20 were male.
The incidence of family history of diabetes mellitus was 14.6% in the diabetics and 12.8% in the glycousuric nondiabetics. This incidence in the nondiabetics was much higher than that of nonglycosuric nondiabetics (1.72%) which was reported by Dr. Rudnick in Hiroshima ABCC.
Of total diabetic patients, the cases detected by this study was 72.7%. This would indicate that the screening test measuring urine sugar is valuable for the detection of diabetes mellitus in this kind of mass survay.
The incidence of hypercholesteremia and of hypertension was statistically higher in the detected diabetics than in the nondiabetics.

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[title in Japanese]

1968 Volume 11 Issue 1 Pages 23-73
Published: January 31, 1968
Released on J-STAGE: August 10, 2011

DOIhttps://doi.org/10.11213/tonyobyo1958.11.23

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