Type 1 diabetes is divided into two categories, autoimmune and idiopathic. Fulminant type 1 diabetes (FT1DM) is a subtype of the idiopathic type, in which islet-related autoantibodies are negative. A 61-year-old woman was admitted to our hospital with the abrupt onset of diabetic ketoacidosis. The plasma fasting glucose level was 30.8 mmol/
l, the HbA1c level was 8.5 % (two days earlier: 7.4 %), the plasma C-peptide level was 0.13 ng/m
l and the urine C-peptide level was<3.4
μg/day. According to the diagnostic criteria for FT1DM, including the rapid onset of hyperglycemia, ketoacidosis and decreasing insulin secretion, the patient was diagnosed with FT1DM. In this case, the titers of glutamic acid dehydrogenase (GAD) antibodies, insulinoma-associated antigen-2 (IA-2) antibodies, islet cell antibodies (ICA) and insulin autoantibodies (IAA) were all positive, suggesting that islet-associated autoimmunity may be involved in the development of FT1DM, although only a few cases of classical acute-onset type 1 diabetes have been reported to show FT1DM-like onset.
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