Cochlear microphonics (CM) and action potential (AP) were measured in animals in which labyrinths were damaged by injection of the various kinds of solution into the facial nerve through the stylomastoid foramen.
The results obtained were as follows:
1) After the injection of tetracycline and hydrochloride, the CM and AP waves were not recorded, even applying the maximal sound stimulus.
2) After the first injection of antigen into the sensitized rabbits, CM amplitude was markedly increased at 4KHz, while increased slightly at 0.5KHz.
After the repeated injections, caloric response was reduced and the CM and AP amplitude decreased or did not show response to the sound stimuli of the 20dB above VDL in both frequencies.
The CM and AP amplitude, however, recovered to the same threshold as before the first injection limits 24 hours after the first procedure.
Histopathological findings of the organ of Corti after the injection of tetracycline and hydrochloride revealed degeneration, but no remarkable change was seen in immunologically treated cases.
It is thought that these electrophysioiogical phenomena induced by the injection of antigen into sensitized animals were resulted from the antigen-antibody reactions in the autonomic nerve and microcirculations in the cochlea.
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