In our continuing search for structurally and biologically interesting metabolites from marine organisms and plants, we investigated the constituents of Okinawan marine sponges and
Hypericum plants, resulting in the isolation of several new and unique natural products. Their structures were elucidated on the basis of spectroscopic analyses and chemical conversions. Novel bromopyrrole alkaloids, nagelamides X-Z, were isolated from a sponge
Agelas sp. Heteroaromatic alkaloids, hyrtimomines A and B, were isolated from a sponge
Hyrtios sp. together with bisindole alkaloids, hyrtimomines C-E. An oxylipin with a trimeric structure, manzamenone O, was obtained from a sponge
Plakortis sp. Dimeric eudesmane sesquiterpenes connected through various linker moieties, halichonadins K-L, were isolated from a sponge
Halichondria sp., and isomalabaricane triterpenes, stelliferins J-N, were obtained from a sponge
Rhabdastrella sp. The investigation for the extracts of
Hypericum plants gave new meroterpenes, acylphloroglucinols, and xanthones. Biyoulactones A-E are meroterpenoids from the roots of
Hypericum chinense. Acylphloroglucinols, chipericumines A-D, and highly prenylated xanthones, biyouxanthones A-D, were also isolated from the same origin. Tricyclic meroterpenes, yezo'otogirins A-C, and liner meroterpenos, yojironins A and B, were isolated from
Hypericum yezoense and
Hypericum yojiroanum, respectively.
抄録全体を表示