Polarographic behavior of 15 kinds of commercial sulfanilamide derivatives was examined and the compounds were classified into four groups. The polarography was carried out with tetramethylammonium bromide as the supporting electrolyte. The compounds which showed one-step reduction wave in non-buffered solution containing 10% of dioxane were classed in Group 1 and it included N
1-(3, 4-dimethyl-5-isoxazolyl) sulfanilamide, N
1-(1-phenyl-5-pyrazolyl) sulfanilamide, N
1-(5-methyl-3-isoxazolyl) sulfanilamide, and N
1-acetylsulfanilamide. Group 2 included the compounds which showed perfect wave in a solution containing around 80% of dioxane and these were N
1-2-pyridylsulanilamide, N
1-2-thiazolylsulfanilamide, and N
1-(3, 4-dimethylbenzoyl) sulfanilamide. The compounds which showed one- to two-step waves in a solution containing 10% of dioxane and also a reduction wave in buffered solution were classed into Group 3 and included N
1-(5-methyl-1, 3, 4-thiadiazol-2-yl) sulfanilamide, N
1-(2, 6-dimethyl-4-pyrimidinyl) sulfanilamide, N
1-(2, 6-dimethoxy-4-pyrimidinyl)-sulfanilamide, N
1-2-pyrimidinylsulfanilamide, N
1-(4-methyl-2-pyrimidinyl) sulfanil amide, and N
1-(6-methoxy-3-pyridazinyl) sulfanilamide. The compounds which failed to show reduction wave in any of these conditions were sulfanilamide and N
1-amidinosulfanilamide, and these were classed in Group 4. Conditions for measurement of sulfanilamide derivatives in Group 1 were examined and it was found that their determination is possible within a concentration range of 0.2-1.0 m
M. Method for this determination was also established.
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