YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
74 巻, 1 号
選択された号の論文の34件中1~34を表示しています
  • Coilに依る濃度曲線の解析
    嘉村 祐一
    1954 年 74 巻 1 号 p. 1-3
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    High freqency analyzer with a coil of under 10 megacycles, which is easy to handle, as an electrode possesses excellent properties at a high concentration. Theoretical observations were made on this apparatus and it was found that the center of sensitivity was at RL, i.e. higher the concentration of the solution, sensitivity transits to the lower frequency range. Calculation of the above equation and experimental evidences are described.
  • 佐伯 孝, 中野 三郎
    1954 年 74 巻 1 号 p. 4-9
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Quantitative determination of Menadione and hydroquinone was carried out by the potentiometric titration and comparison was made with the existing method and the error by the indicator method. It was thereby found that this method was applicable for accurate determination. Hydroquinone was titrated with 0.05N cerium sulfate and Menadione by 0.1-0.01N cerium sulfate solution. There are sufficient data on the standard oxidation potential of hydroquinone that such was measured only on Menadion in the present experiments, with theoretical considerations. Examination of reduction conditions and comparison with the o-phenathroline iron complex were carried out and promising results were obtained. Titration error by this method was found to be extremely small and titration was found to be possible with 0.1, 0.05, 0.02, and 0.01N solutions. It was also observed that the present method was better compared to the results of titanometry. The titration curve tended to become more gradual in strong acid while the addition of sodium acetate gave a negative result in an excessive amount but no influence when added in a small amount. Potential at the equivalence point is a function of acidity, is around 0.5-0.6V, and experimental results agreed well with the theoretical values.
  • 長瀬 雄三, 松本 潮
    1954 年 74 巻 1 号 p. 9-13
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Elbs' persulfate oxidation of α-and β-naphthol gave 41% yield of naphthohydro-quinone (I) from α-naphthol, and 12% yield of 1, 2-dihydroxynaphthalene (II) from β-naphthol.
    2) Oxidation of α-naphthol with 30% hydrogen peroxide was found to give phthalic acid when using diluted sodium hydroxide solution, and 2-hydroxy-1, 4-naphthoquinone (III) (Lawsone) when using conc. alkali hydroxide. β-Naphthol failed to react to this reagent.
    3) In connection with the new preparative method of Lawsone by the oxidation of α-naphthol in 50% potassium hydroxide solution with 30% hydrogen peroxide, addition of pervanadic acid as a catalyst was found to increase the yield from about 15% without the catalyst to 50%.
  • β-Halopropiophenone関連化合物の抗菌力に就いて
    南原 利夫
    1954 年 74 巻 1 号 p. 13-16
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    p-Substituted β-haloethyl ketone derivatives of benzene, acetaminobenzene, and formylaminomethylbenzene were prepared and their bacteriostatic activity in vitro was tested. These compounds were found as effective as acrylophenone compounds against E. coli, Staph. aureus, and Myco. tuberculosis.
    The compounds convert easily to the corresponding acrylophenone in weak alkaline medium under liberation of hydrogen halide. The mode of action of the compounds is assumed to consist of the primary conversion of β-haloethyl ketones to the vinyl ketone form, and reaction of the latter with a certain sulfhydryl group, which is significant to metabolism of organisms.
  • Vinyl Sulfone関連化合物 その抗菌性と反応性に就いて
    南原 利夫
    1954 年 74 巻 1 号 p. 17-20
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Some vinyl sulfones (R-SO2-CH=CH2) and β-chloroethyl sulfones (R-SO2-CH2-CH2Cl) in which R are CH3-, C6H5-, p-CH3C6H4-, and p-AcNHC6H4-, were prepared and their antibacterial activity was tested (Table I). These sulfone compounds possess the same grade of activity as the corresponding ketones (see previous paper) against Myco. tuberculosis and E. coli, but somewhat weaker activity against Staph. aureus. This similarity is expected from the chemical nature of both types. These vinyl sulfones react easily with sulfhydryl, hydroxyl, or amine groups under the formation of β-substituted derivatives. These facts seem to be responsible for their biological activity.
  • 白樺油の殺虫成分について その2 1,2,7-トリメチルナフタリンの合成
    山口 一孝, 庄司 初枝
    1954 年 74 巻 1 号 p. 20-23
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    1, 2, 7-Trimethylnaphthalene (sapotalin) was synthesized via α-methyl-β-(p-toluyl)-propionic acid in order to determine the constitution of a polymethylnaphthalene obtained by selenium dehydrogenation of an insecticidal fraction of a birch tar oil. Some progressive reaction processes are described.
  • ジハイドロクマリンのメチル誘導体の合成並びにその駆虫作用
    中林 利平
    1954 年 74 巻 1 号 p. 23-26
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Dihydrocoumarin and its derivatives possessing the methyl group at 3, 4, 5, 6, 7, 8, and at 4, 7 and 3, 4, 7, were prepared of which only 4, 7-dimethyldihydrocoumarin has been described in literature. In vitro action of these compounds against Ascaris suilla was tested.
    2) Biological tests were made by observing the activity of the ascaris in a glass tube filled with modified Locke solution containing the dihydrocoumarin derivative in a 2, 000 dilution, at 38°.
    3) Time elapsed until complete ceasure of motion in ascaris was taken as the standard by which the effect decreased in the following order: 7-methyl>8-methyl≈dihydrocoumarin>3, 4, 7-trimethyl>3-methyl≈6-methyl-≈4, 7-dimethyl>5-methyl≈4-methyldihydrocoumarin.
    4) This order of efficacy is not parallel with the order of the efficacy of coumarin and its methyl derivatives.
    5) Reduction of the double bond between 3- and 4-positions in coumarin and its methyl derivatives to dihydrocoumarin and its methyl derivatives results in the decrease of efficacy.
  • Ninhydrin反応の中間成績体
    山岸 正治
    1954 年 74 巻 1 号 p. 27-29
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Intermediate products of ninhydrin reaction were obtained from 2-methyl-4-amino- and 2-methyl-4-hydroxy-5-aminomethylpyrimidine. The analytical values of these substances agreed extremely well with the values calculated for 2-methyl-4-aminopyrimidyl (5)- and 2-methyl-4-hydroxypyrimidyl (5)-methylidenediketohydrindamine, and they give Ruhemann purple by reacting further with ninhydrin.
  • 蜂蜜並びに蜂蜜関係物中のアセチルコリンについて その1
    渡邊 武, 後藤 實, 石川 一郎
    1954 年 74 巻 1 号 p. 30-32
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Some acetylcholine-like substances from several kinds of domestic honey were examined by the Magnus method and by paper partition chromatography, and calculated value of 0.1-15γ/g. (average, 10.3γ/g.) was obtained. Honey with its source from Tilia japonica Sink. was found to contain practically no acetylcholine-like substance. The content of such substance in honey collected in different parts of the country was found to be approximately the same when the plant source of honey was of similar species. The content of vitamin B group in honey purified by Japanese acid clay, kaolin, or activated carbon was found to be extremely smaller than in the original honey.
  • 川城 巖
    1954 年 74 巻 1 号 p. 33-36
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Periodate oxidation of toluidines in the presence of five moles of formic acid results in exactly the same reaction course as the oxidizing agent consumption curve during the periodate oxidation of their N-glucosides, from which it has been realized that above five moles of the oxidation agent consumed during the periodate oxidation of N-glucoside was due to the aglucone itself. In the absence of formic acid, consumption of periodic acid by toluidines during oxidation is quite rapid but there seemed to be no fundamental difference. Nitrobenzene was found to have no influence in the reaction of p-toluidine and periodic acid. Acetanilide does not consume periodic acid.
  • INAHの定量法及び体内分布について
    岩本 多喜男
    1954 年 74 巻 1 号 p. 36-39
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    A system for the quantitative determination of isonicotinic acid hydrazide and its decomposition product, isonicotinic acid, in various body organs was established. Using a cat, physiological distribution of INAH was examined and it was found that INAH was absorbed rapidly but that the decomposition did not occur to a great extent. In a perfusion experiment using cat liver, the manner of fixation of INAH in liver became clear and it was assumed that the toxicity of INAH was not the toxicity of INAH itself but of a substance formed from it. It is hoped that further studies may be made on this substance.
  • 8-(p-ヒドロキシフェナチル)-5,7,4´-トリヒドロキシフラボンのメチルエーテル類の合成 (ギンクゲチン分解フラボンの化学構造について)
    中澤 浩一, 松浦 信
    1954 年 74 巻 1 号 p. 40-42
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    8-(p-Methoxyphenacyl) derivatives (V), m.p. 229°, and (VI), m.p. 246°, were prepared by the respective condensation of anisole to 8-carboxymethyl-5-hydroxy-7, 4′-dimethoxy-flavone (III) and its methyl ether (IV) in the presence of polyphosphoric acid. Depression of the melting point occured on respective admixture of these derivatives with the methyl compound, m.p. 224°, of the degradation flavone obtained from ginkgetin, a flavone compound from the leaves of Ginkgo biloba L., and its permethylated product, m.p. 223°. It became necessary, therefore, to carry on further studies on the structure of ginkgetin.
  • Quinaldoin及びQuinaldilに就いて
    鵜飼 貞二, 金原 三郎, 金友 昭一
    1954 年 74 巻 1 号 p. 43-45
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) By the action of potassium cyanide on quinaldehyde, Brown and Hammick obtained a substance (I), which they designated “quinocoll”. From its melting point, ultraviolet absorption spectrum (the second peak at 297mμ), and the process of its formation, it appears not improbable that quinocoll is identical with quinaldil.
    2) Buehler and Edwards made a comparison of the ultraviolet absorption of 1, 2-di-(6-methylquinolyl-2)-1, 2-ethenediol (A) with that of trans-9, 9′-phenanthroin. They showed that the second peak in the absorption spectrum of (A) exhibited a pronounced hypsochromic effect over that shown by the reference compound, but they neglected to consider the absorption of (A) in the visible region. According to our observation a peak appears at 440mμ in the absorption spectrum of quinaldoin in chloroform, which should show similarity to that of (A), and that of quinaldoin dibenzoate in chloroform, having lost hydrogen bonding, possesses a peak at 340mμ; but in the spectrum of quinaldoin dibenzoate in sulfuric acid a peak appears at 410mμ.
    3) The cause of coloration of quinaldoin was assumed to be due to hydrogen bonding which might cause halochromic phenomenon in the quinaldoin molecule.
  • Benzothiazoinに就いて
    鵜飼 貞二, 金原 三郎
    1954 年 74 巻 1 号 p. 45-47
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Benzothiazoin was prepared by the action of KCN on 2-formylbenzothiazole, which crystallizes from xylene as orange needles, m.p. 280-282° (decomp.). Oxidation of benzothiazoin by bromine or air yields benzothiazil (I), m.p. 245°. Carbonyl reagent does not react with benzothiazoin while Tollen's reagent and 2, 6-dichloroindophenol are reduced by it. In the absorption spectrum of benzothiazoin a peak appears at 406mμ, while the peaks in the absorption spectra of its diacetate and its dibenzoate shift to 365mμ, as in the case of quinaldoin dibenzoate, probably due to the loss of hydrogen bonding by acylation. Di (benzothiazolyl-2)-ethylene, m.p. 225-226°, which was prepared from 2-methylbenzothiazole and 2-formylbenzothiazole, shows a peak at 368mμ in the absorption spectrum. From the above results a structural formula (II) is proposed for benzothiazoin. The absorption curve of benzothiazoin in pyridine solution is quite different from that in chloroform solution, while the absorption curve of quinaldoin in pyridine solution is similar to that in chloroform solution. This is probably because the basicity of benzothiazole is less than that of quinoline and the hydrogen bonding of benzothiazoin is weaker than that of quinaldoin.
  • 3-アリルサリチルアルデヒド及びアルキルフェニルケトン誘導体について
    高橋 酉藏, 大鹿 隆男
    1954 年 74 巻 1 号 p. 48-51
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Aniline, o-and p-anisidine were respectively applied to 3-allylsalicylaldehyde and corresponding Schiff bases were obtained. Condensation of the latter with β-diethylaminoethyl chloride gave three kinds of basic phenol alkyl ethers.
    2) Allyl bromide was applied to 2 (4)-hydroxyphenyl and 2-hydroxy-5-methylphenyl alkyl ketones to obtain the corresponding allyloxy derivatives which were submitted to the Claisen conversion and 2 (4)-hydroxy-3-allyloxyphenyl and 2-hydroxy-3-alkyl-5-methylphenyl alkyl ketones were obtained. Application of β-diethylaminoethyl chloride to these 2 (4)-hydroxy-3-allyl derivatives gave five kinds of basic phenol alkyl ethers.
    3) These ethers were prepared in order to test their activities as uterus contracting agent.
  • アミノチクロヘキサン誘導体について その1
    高橋 酉藏, 堀 幹夫
    1954 年 74 巻 1 号 p. 52-55
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Grignard reagents prepared from methyl iodide, ethyl bromide, butyl bromide, benzyl chloride, and phenyl bromide were applied respectively to 2-dimethylaminomethylcyclohexanone and the corresponding 1-alkyl (aralkyl, aryl)-2-dimethylaminomethylcyclohexanols were prepared. Various aromatic acid chlorides were applied to the latter to obtain the corresponding esters. One of these esters, 1-methyl (or ethyl)-1-p-nitrobenzoxy-2-dimethylaminomethylcyclohexane was reduced to the p-aminobenzoxy derivative. Some of the above esters were found to possess striking anodynic action.
  • N-置換Tetrahydrofurothiazole-2-thione化合体及びその関係化合物について その1
    平野 弘
    1954 年 74 巻 1 号 p. 56-59
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Heating of α-aceto-γ-hydroxypropyl N-[2-methyl-4-aminopyrimidyl-(5)]-methyldithiocarbamate (I) with an acid gives 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazole-2-thione (S-B1) (III). A new substance of m.p. 175-176° was isolated as the intermediate product of the reaction. As a result of various experiments, the new substance here obtained was assumed to be an isomer of S-B1, 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyltetrahydrofurano (2, 3-d) thiazole-2-thione (II) whose thiocarbonyl group changes to the carboxyl when warmed in alkali solution to a substance, m.p. 179-180°, assumed to be 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyltetrahydrofurano (2, 3-d) thiazol-2-one (VII). This substance is an isomer of 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazol-2-one (vitamin B1 thiazolone) (VIII).
  • N-置換Tetrahydrofurothiazole-2-thione化合体およびその関係化合物について その2
    平野 弘
    1954 年 74 巻 1 号 p. 59-62
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Comparative examinations were made on the application of mercuric chloride, sodium bicarbonate, acid hydrogen peroxide, and alkaline hydrogen peroxide on 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyltetrahydrofurano (2, 3-d)-thiazolo-2-thione (V), described in the preceding report, on S-B1 (I), and on α-aceto-γ-hydroxypropyl N-[2-methyl-4-aminopyrimidyl-(5)]-methyldithiocarbamate (VIII). In the present series of experiments, a substance assumed to be the isomer of thiochrome, 2, 7-dimethyl-7, 9, 10, 11-tetrahydrofurano (2, 3-h) thiochromine (VI), was isolated on application of mercuric chloride and sodium bicarbonate on (V) and of acid hydrogen peroxide on (VIII). (VI) changes to thiochrome on the application of an acid.
  • 濾紙通電クロマトグラフの基礎的研究 その1
    安永 峻五, 下村 脩
    1954 年 74 巻 1 号 p. 62-66
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    A filter paper wetted with an electrolyte was placed between two glass plates coated with a silicone resin. Electric current was passed through this paper in order to find the relationship between the time, voltage, electric current, and temperature with degree of mobility of numerous inorganic ions. It was found that a linear relation always existed, in any of the electrolyte used, between the distance of mobility and time and voltage. The effect of electric current was examined with sodium nitrate as an electrolyte and it was found that electric current did not influence the mobility of the ions as much as voltage. A metallic thermostatic vat, coated with insulating paint, was devised and the mobility of ions at various temperatures was examined and it was found that the mobility generally increased with the increase of temperature and this influence was found to be greater the larger the mobility of the ion. Influence of evaporation by the warming of the filter paper was quantitatively examined, using the Durrum apparatus, with either direct or alternative current as the electric source, from the relationship between the position of the sample placed and the distance of ionic mobility. It was thereby unexpectedly found that a great deal of effect was caused by evaporation.
  • 濾紙通電クロトマトグラフの基礎的研究 その2
    安永 峻五, 下村 脩
    1954 年 74 巻 1 号 p. 66-68
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Relationship between the pH of the electrolyte solution and the degree of mobility was examined with inorganic ions. Electrolyte used were sodium nitrate, potassium thiocyanate, and tartaric acid series, and the ions detected were Ba++, Pb++, Cu++, Zn++, Ni++, Fe+++, Br-, CNS-, AsO4---, CrO4--, Fe(CN)6---, NO2-, and BO3---. Except in the case of extremely acid or alkaline range, the effect of pH was found to be rather small in inorganic ions in general, both in cations and anions. However, in the case of amphoteric metals, such as zinc, they behave similar to amino acids. Use of complex salt-forming electrolyte in the case of metallic ions, the effect of pH was found to be extremely great. In the case of tartaric acid electrolyte, metals were found to move as a cation in the acid range of lower pH while they behaved as anions in a higher pH range, and there is a certain pH (isoelectric point) at which each metal does not move at all. From these facts, it was found that the complex salt-forming electrolyte was suitable for the separation of metals.
  • カルボン酸によるフェノールのアシル化 (フェノールの新アシル化法)
    中沢 浩一, 松浦 信
    1954 年 74 巻 1 号 p. 69-72
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Phenols are easily acylated by carboxylic acids, in the presence of polyphosphoric acid, by being allowed to stand for 24 hours or by being heated on a boiling water bath for 10-30 minutes. The results obtained by such reaction are as follows:
    1) Phenol and acetic acid give the ester by cold reaction and p-hydroxyacetophenone by hot reaction.
    2) Resorcinol and acetic acid give the ester by cold reaction and resacetophenone, its 4-acetyl compound, and 4, 6-diacetylresorcinol by hot reaction.
    3) Phenol and resorcinol give, by benzoic acid, benzoic acid ester by hot reaction.
    4) Hydroquinone, phenolphthalein, and diphenolisatin give corresponding esters by various carboxylic acids.
  • ウチワドコロ, タチドコロ, カエデドコロ及びヒメドコロのサポゲニン
    塚本 赳夫, 川崎 敏男
    1954 年 74 巻 1 号 p. 72-75
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Sapogenin contained in four kinds of Dioscoreaceae family, Dioscorea nipponica Makino, D. gracillima Miq., D. quinqueloba Thunb., and D. tenuipes Franch et Sav., was examined by the Marker method and all were found to have diosgenin as the chief sapogenin. Paper chromatography was carried out on the crude and purified sapogenins or their acetate by the Sannié and Heftmann method for the identification of sapogenin and examination of occluded substances.
  • α, π-Dihalocamphorの発烟硫酸による異性化 補遺 その1 α, ω-Dihalo-d-camphor-trans-π-sulfonic Acid について
    西川 正元, 萩原 彦一
    1954 年 74 巻 1 号 p. 76-80
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    It has previously been reported that the application of fuming sulfuric acid to α, π-dihalo-d-camphor resulted in isomerization to form 6-trans-π-dihalo-ι-camphor. Two kinds of dihalocamphorsulfonic acids, unknown to date, were separated from the sulfuric acidmother liquor obtained as a by-product by the foregoing isomerization on α, π-dichloro-and α-chloro-π-bromo-d-camphor, and these were confirmed to be α, ω-dichloro-d-camphor-trans-π-sulfonic acid (IV) and α-chloro-ω-bromo-d-camphor-trans-π-sulfonic acid (IV′). These two kinds of sulfonic acids easily undergo desulfurous acid reaction in aqueous acid solution to give α, ω-dichloro-trans-π-hydroxy-d-camphor (V) and α-chloro-ω-bromo-trans-π-hydroxy-d-camphor (V′), respectively. The dihalohydroxycamphors were derived to α, ω-dichloro-trans-π-bromo-d-camphor (IX), α-trans-π-dichloro-ω-bromo-d-camphor (IX′), ω-chloro-trans-π-hydroxy-d-camphor (VI), and its oxidation products, ω-chloro-trans-π-keto-d-camphor (VII), and ω-chloro-d-isoketopinic acid (VIII), which are all new compounds.
  • α, π-Dihalocamphorの発烟硫酸による異性化 補遺 その2 α-trans-π-Dihalo-d-camphor-ω-sulforic Acidについて
    西川 正元, 萩原 彦一
    1954 年 74 巻 1 号 p. 81-84
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    It had been shown that α, ω-dihalo-d-camphor-π-sulfonic acid was isolated from the sulfuric acid mother liquor formed on the isomerization of α, π-dihalo-d-camphor by fuming sulfuric acid. Later, it was found that another unknown camphorsulfonic acid was still present in the sulfuric acid solution and this acid was confirmed as α, π-dihalo-d-camphor-ω-sulfonic acid. When the amount of fuming sulfuric acid used in the foregoing isomerization is small, a larger amount of ω-sulfonic acid is formed in place of π-sulfonic acid. ω-Sulfonic acid, differing from π-sulfonic acid, does not undergo desulfurous acid reaction but its sulfobromide does undergo this reaction, as in the case of camphor π-sulfobromide or ω-sulfobromide to give a bromo derivative.
  • ジゲニン酸の比色定量 その1
    村上 信三, 竹本 常松, 清水 然昌, 醍醐 晧二, 樋口 進
    1954 年 74 巻 1 号 p. 85-87
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    A comparatively stable yellow color, with absorption maximum at 400mμ, appears when a buffer solution (pH 7.0-7.1) of digenic acid and ninhydrin solution are mixed and warmed at 60° for 30 minutes, and this can be utilized for colorimetric determination of digenic acid.
  • ジゲニン酸の比色定量 その2
    村上 信三, 竹本 常松, 清水 然昌, 醍醐 晧二, 樋口 進
    1954 年 74 巻 1 号 p. 88-89
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    The yellow coloration which appears on mixing and warming the buffer solution of digenic acid and ninhydrin solution under suitable conditions transit easily into isoamyl alcohol layer from the aqueous solution. These points can be conveniently be utilized for the colorimetric determination of digenic acid when the sample solution is turbid.
  • キノン系化合物処理について その2
    鈴木 周一
    1954 年 74 巻 1 号 p. 90-93
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Following experimental results were obtained regarding the mechanism on the removal of Pyrogen× (TBP-reaction positive substance) by quinone treatment of pyrogen solution:
    1) Quinone treatment was carried out on pyrogen solution, in the original high concentration and in lower concentration of 400 dilution and both were found to give negative TBP reaction of practically the same degree of coloration.
    2) In the treatment of quinone-treated solution with activated carbon, experiments were carried out with varied length of time of contact and at varied temperatures. When treated at a high temperature or for a long time, TBP reaction remained positive and a fairly large amount of Pyrogen× seemed to be present. On the other hand, when the carbon treatment was carried out at a room temperature or as short a time as possible, TBP reaction was found to become negative.
    3) When the activated carbon used for the adsorption of the quinone treatment solution is heated in distilled water and filtered, the filtrate was found to give positive TBP reaction from which it became certain that the Pyrogen× adsorbed on the activated carbon is again liberated into water.
    4) It was clarified that when this liberated Pyrogen× is treated again with quinone, the solution would again give negative TBP reaction.
    5) Adsorptive removal of Pyrogen× by carbon added with quinone-like substance was found to be ineffective.
    From the foregoing results it was assumed that TBP-reaction positive substances (Pyrogen×) behaved in the same manner against quinone treatment and further, that the Pyrogen× removal by quinone treatment was effected by the following formulae:
    P×+Q→P×Q P×Q+C→CP×Q→CQ+P× where P× is Pyrogen×, Q, ρ-quinone, and C, activated carbon.
  • 日本産敗醤の剖見と化学的成分に関する知見
    藤田 路一, 古谷 力
    1954 年 74 巻 1 号 p. 94-98
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Morphological studies were carried out on the underground portions of Patrinia scabiosaefolia Link and P. villosa Juss. From the difference of the two kinds thereby learned, the domestic crude drug Hai-shô, the root of Patrinia species, was confrimed as being derived from P. scabiosaefolia. A histochemical examination suggested the presence of a saponin in the root and rhizome of both kinds which showed hemolytic reaction. Saponin was isolated from the crude drug as colorless scaly crystals whose hydrolysis yielded sapogenin, glucose, arabinose, and xylose. The infrared absorption spectrum of the sapogenin agreed with that of oleanolic acid.
  • 完全混成 Brooker 型色素の新合成法
    田邊 良久
    1954 年 74 巻 1 号 p. 98-101
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Some time ago, as described in Part XVI of this series1, it had been discovered that in the synthesis of unsymmetric Brooker-type dyes, when the nuclear basicity of the anilino compound to be applied at the final stage to the meso-position is strong, nuclear substitution was likely to occur. Therefore, anilino compound of weaker nuclear basicity, i.e. 2-phenylaminoethenylbenzothiazolium ethiodide and 2-phenylaminoethenylbenzoxazolium ethiodide was applied, in the presence of anhydrous potassium acetate, in acetic anhydride, to 1, 1′-diethyl-meso-anilino-4, 2′-trimethylenequinocyanine 1, 1′-dihalide by which unsymmetric Brooker-type dyes were successfully obtained as 1, 1′, 1″-triethyl-meso-(2″-benzothiazolyl)-vinyl-4, 2′-trimethinequinocyanine 1, 1″-diiodide and 1, 1′, 1″-triethyl-meso-(2″-benzoxazolyl)-vinyl-4, 2′-trimethinequinocyanine 1, 1″-diiodide.
  • 氷酢酸を溶媒とする溶性バルビタール類及び溶性サッカリンの滴定
    鹿島 哲
    1954 年 74 巻 1 号 p. 101-104
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Barbituric acid derivatives and salts and their allied compounds used as medicinal drugs were titrated as approx. 0.1N glacial acetic acid solution (25cc.) at around 25° with 0.1N perchlorate solution, using calomel-glass electrode. The titration curves were very sharp and the precision of determination was approx. 0.05%. Titration using crystal violet, malachite green, methyl violet, or neutral red as an indicator was found to be almost as accurate as the potentiometric titration if one of the first three indicators was suitably used. This titration by the indicator is suitable as a method for Pharmacopoeia test in the face of the fact that there are no other good quantitative method. Only in the case of ethylhexabital calcium, it was found necessary to use a comparative standard for end point because of its weak basicity. It is necessary to shut off air during titration, to maintain the moisture of glacial acetic acid around 1-0.5%, to correct the concentration of 0.1N perchlorate standard with the expansion coeffcient of glacial acetic acid, and to maintain the temperature difference of the room during titration to within 0.5°. The dielectric rate of glacial acetic acid is considerably lower than that of water that the titration must be made slowly. When the sample contains some impurities such as sodium carbonate the value will be extremely larger than the actual content.
  • チエニルブタノールアミン類の合成 その1
    平尾 一郎, 水沼 清, 林 正樹
    1954 年 74 巻 1 号 p. 105-106
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the application of dimethylamine on propenyl ketones (II, V), corresponding amino ketones (III, VI) were obtained. By the application of organic lithium compound to these compounds (IV, VII, VIII), assumed to possess antispasmodic and other biological actions, were prepared.
  • 竹本 常松, 清水 然昌, 醍醐 皓二, 崔 達英
    1954 年 74 巻 1 号 p. 107-109
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Some good results were obtained by the treatment of ascariasis with a mixture of digenic acid and santonin.
  • アレチノギクの成分について
    今井 統雄, 眞山 節子
    1954 年 74 巻 1 号 p. 109-110
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
    Pyromeconic acid, contained in the flower of Erigeron annuus L., is totally absent in the flower of E. bonariensis L.. Crystals obtained from the ether-soluble portion were confirmed to be those of quercetin and those from the ethyl acetate-soluble portion, quercitrin.
  • 増田 亨, 那波 速男, 浅井 満子
    1954 年 74 巻 1 号 p. 111
    発行日: 1954/01/25
    公開日: 2010/02/19
    ジャーナル フリー
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