巻号一覧
87 巻, 6 号
選択された号の論文の33件中1～33を表示しています
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池本 文彦, 岩田 修造, 成田 不二生1967 年 87 巻 6 号 p. 611-616
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーIn order to examine the action of various chemicals on the crystalline lens, a new experimental method was devised using the crystalline lens in vitro. The conditions of the lens after excision was examined on the basis of whether the cationic transport was normal or not. Changes in the condition of the lens would result in its opacity and also by various biochemical changes. In the present experiment, cationic transport function of the lens decreased first, and outflow of potassium from the lens was found to precede other changes. In the in vitro experiment, outflow of potassium from the lens was accelerated by ice cooling and by the administration of ouabain or monoiodoacetic acid. These evidences suggest that the examination of cationic transport of the lens by the present method is an effective means in the examination of lens functions.抄録全体を表示PDF形式でダウンロード (747K) -
小木曾 健人1967 年 87 巻 6 号 p. 617-622
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーTwo kinds of crystals were obtained by the reaction of histidine and cupric ion. The ratio of histidine and copper was found to be 1 : 1 and 2 : 1 (Table I). The former was insoluble while the latter was soluble in methanol. The chromatographic separation of these copper-histidine chelates on silica gel G was achieved by development with a mixture (9 : 1) of methanol and water (Fig. 1). The structures of copper-histidine chelates were presumed from infrared data. In the copper-histidine chelate of 1 : 2, the coordination from the α-amino nitrogen and the nitrogen of imidazole to copper could be presumed. The carbonyl-oxygen approaches the copper closely enough to be considered as loosely bound (Fig. 6-a). In the copper-histidine chelate of 1 : 1, the coordination through the carbonyl group and the nitrogen of the imidazole ring was presumed to form a seven-membered ring (Fig. 6-b).抄録全体を表示PDF形式でダウンロード (679K) -
板谷 元一, 服部 英機, 河村 典久, 安江 政一1967 年 87 巻 6 号 p. 623-626
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーSyntheses of the subject compound were carried out and two kinds of compounds (V : R=CH3 and C6H5CH2) having a substituent in 1-position were obtained by the route shown in Chart 1. In the reaction of 3-nitro-4-chloroacetophenone (I) and amines, by-product formation was observed besides the main product, the ketone compound (II : R=CH3 and C6H5CH2), as follows : (1) In the case of methylamine, the imino compound (III : R=CH3) was produced and this was found to be related to the amount of the amine used (Table I). (2) In the case of benzylamine, 2, 6-bis (4-benzylamino-3-nitrophenyl)-4-phenylpyridine (VIII) formed as a by-product (Chart 2). In order to obtain V by the reductive cyclization with sodium dithionite, acetylation and benzoylation of II were attempted but neither materialized. Therefore, II was reduced to the diamine compound (IV) and was obtained by the Phillips method. Ultraviolet absorption spectra of II and V (Fig. 1 and 2) showed that the maximum absorption of V has become extremely broad and this was considered to be due to the presence of a carbonyl group in 5-position.抄録全体を表示PDF形式でダウンロード (524K) -
松本 昌次, 宮崎 道彦1967 年 87 巻 6 号 p. 627-630
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーIn order to examine the industrial method for the manufacture of D-ribose, constant current electrolytic reduction of D-ribonolactone was carried out. It was found that the yield of D-ribose was increased by the use of the ammonium salts ((NH4)2SO4, (NH4)2HPO4, (NH4)H2PO4, NH4Cl, NH4NO3) in place of the alkali metal salts (Na2SO4, Li2SO4) hitherto used as the electrolyte in this kind of electrolysis. As a reason for this increased yield, an attempt was made to endorse the assumption based on the interfacial structure at the contact surface between the electrode and the electrolyte solution by a comparative experiment using ammonium sulfate and sodium sulfate as the electrolyte. It was also revealed that the addition of boric acid was effective to some extent in preventing the formation of D-ribitol.抄録全体を表示PDF形式でダウンロード (521K) -
菊池 徹, 上尾 庄一郎, 西永 俊也, 井深 俊郎, 加藤 旭1967 年 87 巻 6 号 p. 631-639
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーAmong the series of alkaloids isolated from Pachysandra terminalis SIEB. et ZUCC. (Japanese name "Fukki-so"), mass spectra were measured of the structurally established 5α-pregnane type alkaloids, especially steroid alkaloids with oxygen function in the 4-position, and their derivatives, and their fragmentation mechanism was examined.抄録全体を表示PDF形式でダウンロード (800K) -
大井 尚文, 稲葉 栄司1967 年 87 巻 6 号 p. 640-642
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーNew infrared spectrophotometric methods are offered for rapid determination of saccharin sodium, dulcin, and sodium cyclamate in their mixture. These components are sparingly soluble in ordinary organic solvents used in infrared analyses, and methanol and water are chosen as solvents. In methanol solution, the absorption bands at 1149 and 1512 cm-1 are used for the determination of saccharin sodium and dulcin, respectively, and in aqueous solution, the absorption band at 1194 cm-1 is used for the determination of sodium cyclamate. These methods gave good results in different standard mixed samples and these are very useful for routine analyses with simple operation.抄録全体を表示PDF形式でダウンロード (445K) -
林 英作, 三浦 勇二1967 年 87 巻 6 号 p. 643-647
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーAs a supplement to the preceding report, N-oxidation of 2-alkylquinoxalines [ethyl (II), isopropyl (III), tert-butyl (IV)] with monoperphthalic acid was attempted. From its result, considerations were made on the effect of the alkyl group on the adjacent ringnitrogen. With the ethyl group, its electronic effect (its electron-donating nature is considered to increase the basicity of the adjacent ring-nitrogen and accelerate N-oxidation) is offset by its steric effect (considered to interfere with N-oxidation by the steric interference), and the substituent does not affect the reaction to a great extent. In the isopropyl and tert-butyl groups, their steric effect becomes greater, and the formation of N-oxide become difficult in the case of ring-nitrogen adjacent to the tert-butyl group.抄録全体を表示PDF形式でダウンロード (619K) -
林 英作, 三浦 勇二1967 年 87 巻 6 号 p. 648-650
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーIn the case of benzimidazole and its derivatives, N-oxidation by the conventional method does not produce the corresponding N-oxides, but its reason is still unknown. In an earlier work, Hayashi ane Iijima obtained 2-phenylbenzimidazole 3-oxide (VI) by the application of hydrogen peroxide to 2-phenylquinoxaline 4-oxide (V) in the presence of alkali hydroxide. By the use of this procedure, 2-alkyl-(IX) and 2-alkoxybenzimidazole 3-oxide (X) were prepared from 2-alkyl-(VII) and 2-alkoxy-quinoxaline 4-oxide (VIII) (Table I).抄録全体を表示PDF形式でダウンロード (472K) -
林 英作, 星 由利子1967 年 87 巻 6 号 p. 651-653
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーApplication of alkylmagnesium halide to phenanthridine (IV) results in the formation of 6-alkyl-5, 6-dihydrophenanthridine (V) (Table I). Heating of V with picric acid results in its oxidation to 6-alkylphenanthridine (I) (Table II). Application of monoperphthalic acid to I gives the corresponding 5-oxide (VI) (Table III).抄録全体を表示PDF形式でダウンロード (423K) -
篠田 雅人, 岡 孝己, 玉置 文一, 赤星 三弥1967 年 87 巻 6 号 p. 654-657
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーIn order to establish the potency test for chemical radiation protectors, radiosensitivity of various strains of mice to X-ray irradiation was examined. The mice used were ddY, CF1, and CRF1 strainrs, and it was found that the survival rate 30 days after irradiation and the mean survival time were both effective indices of radiation injury. Since the variation in radiation dosage, and the strain and age of mice affected the radiosensitivity, optical conditions for biological assay of chemical radiation protectors were determined as follows. When using ddY strain mice, those of 4∼7 weeks of age should be used and given X-ray irradiation of 700R. With CRF1 strain mice, 600 R dose seems to be appropriate. In the case of CF1 strain mice, radiation dosage and variation in survival rate failed to show linearity and this strain of mice is considered to be unsuitable for this biological assay.抄録全体を表示PDF形式でダウンロード (519K) -
篠田 雅人, 後藤 百子, 岡 孝己, 岩田 京子, 玉置 文一, 赤星 三弥1967 年 87 巻 6 号 p. 658-662
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーWhen experimental animals are irradiation with radiation rays, various disorders result but the marked change in the initial stage is the loss in body weight. In order to see if this loss in weight could be used as an index for biological assay of chemical radiation protectors, sensitivity of mouse weight to irradiation was examined. The body weight of male ddY mice shows specific loss on X-ray irradiation, and the rate of body weight change two weeks after the irradiation is linear to the dose of irradiation. This rate of body weight change is much more sensitive than changes in survival rate, and effect of irradiation can be observed with a low dose and in a short period.抄録全体を表示PDF形式でダウンロード (662K) -
山崎 高応, 永田 正典, 菅野 紘, 井上 信1967 年 87 巻 6 号 p. 663-667
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリー2-(2-Aminoethyl) pyridine (XII), obtaind by the reduction of 2-(cyanomethyl) pyridine (XI) over Raney nickel catalyst at 80° at a high preasure, was derived to an urethan (XIV) by ethyl chlorocarbonate. The urethan was hydrogenated over Raney nickel catalyst at 130° at a high pressure, followed by ring closure to 2, 3, 4, 4a, 5, 6, 7, 8-octahydro-1H-pyrido [1, 2-c]-pyrimidin-1-one (IV), which was reduced with lithium aluminium hydride to 2, 3, 4, 4a, 5, 6, 7, 8-octahydro-1H-pyrido [1, 2, -c] pyrimidine (I). I and its 4-substituted derivatives (Ia∼I) were also obtained from the corresponding aldehydes and 2-(β-aminoethyl) piperidine.抄録全体を表示PDF形式でダウンロード (565K) -
山崎 高応, 永田 正典, 小川 清美, 野原 冨士夫1967 年 87 巻 6 号 p. 668-671
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーEthyl 2-piperidinecarboxylate was converted to the corresponding 1-cyanomethyl compound (I) by the strecker synthesis. I was reduced over Raney nickel catalyst at 130° at high pressure to 1, 3, 4, 6, 7, 8, 9, 9a-octahydro-2H-pyrido [1, 2-a] pyrazin-1 (9aH)-one (II). II was reduced to 1, 3, 4, 6, 7, 8, 9, 9a-octahydro-2H-pyrido [1, 2-a] pyrazine (III) with lithium aluminum hydride. The compound III was also prepared by another method according to the following process. 2-(Aminomethyl) pyridine was reacted with chloroacetyl chloride to give 2-(chloroacetamidomethyl) pyridine which was cyclized to the corresponding pyridinium salt (VI) by heating in alcoholic solution for 3 hr. The salt (VI) was then reduced over platinum oxide catalyst to 1, 3, 4, 6, 7, 8, 9, 9a, -octahydro-2H-pyrido [1, 2-a] pyrazin-3 (4H)-one (VII), which was reduced with lithium aluminium hydride to III.抄録全体を表示PDF形式でダウンロード (487K) -
清水 和子, 坂本 征則, 福島 清吾1967 年 87 巻 6 号 p. 672-676
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーAttempts were made to synthesize the compounds in which the γ-pyrone ring was condensed to pyridine and the pyridine portion of quinoline. Ethyl 2-methoxynicotinate was cyclized via 2-methoxy-3-acetoacetylpyridine to 2-methyl-4H-pyrido [2, 3-b] pyran-4-one. Similarly, application of sodium and acetone to methyl 2-methoxy-3-quinolinecarboxylate afforded 2-methoxy-3-acetoacetylquinoline but its cyclization reaction of in polyphosphoric acid gave 1-methyl-4-hydroxy-3H-cycloperta [2, 3-c] quinolin-3-one and not the expected 2-methyl-4H-pyrano [2, 3-b] quinolin-4-one.抄録全体を表示PDF形式でダウンロード (597K) -
藤本 克郎, 清水 当尚, 岡 武哲, 高瀬 善行, 大西 久美雄, 内海 健二朗, 中西 豊, 於勢 真輔1967 年 87 巻 6 号 p. 677-681
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーThe characteristics of iron-chondroitinsulfate were biologically investigated by its intravenous administration to experimental animals. Much stained iron was detected in reticular cells of hematopoietic organs and therapeutic effect on experimental anemia was observed. On the other hand, no serious toxic effects were observed in both general pharmacological and hematological analyses. From these results, it was considered that iron-chondroitinsulfate might be one of the hematopoietics which could be safely administered intravenously.抄録全体を表示PDF形式でダウンロード (646K) -
亀谷 哲治, 菊地 豊彦1967 年 87 巻 6 号 p. 682-686
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーNuclear Magnetic Resonance spectrum of 5-hydroxy-1-(α-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline (II) was measured and it was found that the methylproton of the methoxyl in 7-position and the ring proton at C-8 were shifted considerably to the higher magnetic field than their normal positions. Therefore, 1-(α-hydroxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives (III) to VII) were prepared by the oxidation of the corresponding 3, 4-dihydro-isoquinolines by alumina treatment followed by the reduction of its products with sodium borohydride. Examination of the NMR spectra of these compounds gave the same result as that of I. The reason for this shift was considered to be due to the fixation of the phenyl in the benzyl group at 1-position by the formation of an intramolecular hydrogen bonding between the lone-pair electrons of the tertiary nitrogen and the α-hydroxyl group, and the magnetic anisotropy of this fixation affects the methyl proton of the methoxyl group in the 7-position and the ring proton at 8-position. The formation of this intramolecular hydrogen bonding was proved by the dilution method in infrared spectrum.抄録全体を表示PDF形式でダウンロード (528K) -
林 英作, 東野 武郎, 大石 悦男, 佐野 勝1967 年 87 巻 6 号 p. 687-688
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリー1-(Methylsulfonyl)-4-phenylphthalazine (I) is obtained by the oxidation of 1-(methylthio)-4-phenylphthalazine (II) with potassium permanganate. The use of hydrogen peroxide as the oxidation agent gives, not I but 4-phenyl-1 (2H)-phthalazinone (III), which is also obtained on heating I with alkali or acid. Heating of I with sodium methoxide gives 1-methoxy-4-phenylphthalazine (IV), while that of I with aniline gives 1-anilino-4-phenylphthalazine (V). From these results, it is seen that the ring-carbon at 1-position in I is reactive to nucleophilic reagents by the -M effect of the ring-nitrogen and -I effect of the methylsulfonyl group.抄録全体を表示PDF形式でダウンロード (362K) -
加藤 鉄三, 後藤 良宣, 千葉 卓男1967 年 87 巻 6 号 p. 689-690
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーTreatment of methyl 2-pyridyl ketone oxime and methyl 3-pyridyl ketone oxime with phosphorus pentachloride gives the corresponding rearrangement products, N-(2-pyridyl)-acetamide and N-(3-pyridyl) acetaminde, but methyl 4-pyridyl ketone oxime does not undergo this rearrangement by the same treatment. However, treatment of the latter with polyphosphoric acid gives 2, 5-(4', 4''-dipyridyl) pyrazine. The treatment of the N-oxides of these compounds with polyphosphoric acid does not give any definable product and results in the recovery of the starting material or resinification.抄録全体を表示PDF形式でダウンロード (360K) -
加藤 鉄三, 山本 豊, 関田 寛, 坂本 尚夫1967 年 87 巻 6 号 p. 691-694
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーReaction between 11 kinds of Schiff base (Ib to Il) and diketene was carried out and six of these, i.e. N-benzylidenepropylamine (Ib), N-benzylidenecyclohexylamine (Ic), N-cinnamylidenecyclohexylamine (Id), N-ethylidene-tert-butylamine (Ie), N-ethylidenecyclohexylamine (If), and N-isobutylidenecyclohexylamine (Ig), afforded the corresponding 2-alkylideneacetoacetamide derivatives (IIb to IIg), whose catalytic reduction gave the 2-alkylacetoacetamide derivatives (IIIb to IIIg).抄録全体を表示PDF形式でダウンロード (446K) -
加藤 鉄三, 今野 昌悦1967 年 87 巻 6 号 p. 695-698
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーTreatment of acetonedicarboxylic acid (I) with acetic anhydride gives 3, 5-diacetyltetrhdro-4H-pyran-2, 4, 6-trione (IIb) but the same reaction with more purified I (not containing sulfuric acid) gives 4-acetoxy-3, 4-dihydro-2H-pyran-2, 6-dione (V). Heating of V with an equivalent amount of aniline in benzene affords the monoanilide (IX or IX') of acetoxyglutaconic acid.抄録全体を表示PDF形式でダウンロード (516K) -
谷 千秋, 高尾 佐知子1967 年 87 巻 6 号 p. 699-701
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーThe presence of protopine and γ-homochelidonine (=β-allocryptopine) as alkaloids of Bocconia frutescens has already been proved but the presence of α-allocryptopine, chelerythrine, and sanguinarine is only assumed. In order to elucidate this point, examinations were made on Brazilian Bocconia frutescens and α-allocryptopine, chelerythrine, and sanguinarine were isolated and identified, besides protopine. One other base of m.p. 268° was also isolated.抄録全体を表示PDF形式でダウンロード (475K) -
枡井 雅一郎, 飯島 千之1967 年 87 巻 6 号 p. 702-703
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーReaction of formaldoxime with hydrogen cyanide yields two compounds (I and II). I is a very unstable new member of the N-cyanoalkylhydroxylamine series, but II is a stable new compound. The structure of II was identified by Infrared and Nuclear Magnetic Resonance spectra, and the reaction scheme was proposed.抄録全体を表示PDF形式でダウンロード (376K) -
西海枝 東雄, 谷口 陽一1967 年 87 巻 6 号 p. 704-711
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーThe Perkin reaction of 5-nitro-2-thiophenecarboxyaldehyde (XII) and monobromoacetic acid afforded 2-bromo-3-(5-nitro-2-thienyl) acrylic acid (X), which was also obtained by oxidation of XI. Dehydrobromination of 2, 3-dibromo-3-(5-nitro-2-thienyl)-propionic acid (IV) afforded 2-bromo-3-(5-nitro-2-thienyl) acrylic acid (IX) (α-form) as yellow crystals of m.p. 95.5∼97°, and its β-form as yellow needles, m.p. 255∼256° (decomp.). Heating of IX in dioxan with hydrochloric acid gave αβ-form 2-bromo-3-(5-nitro-2-thienyl) acrylic acid. (X). Infrared and ultraviolet spectra of VIII and IX suggested that they are stereoisomers. Dehydrobromination of ethyl 2, 3-dibromo-3-(5-nitro-2-thienyl) propionate afforded the α-form (yellow prisms, m.p. 94∼95°) (VI) and β-form (yellow needles, m.p. 127∼128°) (VII) of ethyl 2-bromo-3-(5-nitro-2-thienyl) acrylate. VII was obtained on heating VI and they were found to be stereoisomers from their infrared and ultraviolet spectra. Hydrolysis of VI and VII gave the same VIII, and therefore, the bromine atom liberated by the dehydrobromination of III and IV was found to have been in the 2-position.抄録全体を表示PDF形式でダウンロード (921K) -
小松 曼耆, 岡野 定輔1967 年 87 巻 6 号 p. 712-718
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーColumn chromatography of bufo steroids over silica gel by the dry method was examined. The use of acetone-cyclohexane mixture, which showed good separability in thin-layer chromatography, as the developer effected much better and faster separation than by the hitherto used wet method. Column chromatography of bufo steroids was found to be much better over silica gel than alumina from the point of stability. Recovery rate of resibufogenin from dried toad venom by the present method was approximately quantitative.抄録全体を表示PDF形式でダウンロード (763K) -
久保寺 昭子, 赤松 譲, 毛利 哲郎, 鶴藤 丞1967 年 87 巻 6 号 p. 719-725
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーSome of the present investigators already reported on the inhibitory effect of strong cation exchange resins on radiostrontium absorption in the gastrointestinal tracts at the 3rd Japan Isotope Conference. In the present work further investigations were made on sulfonated polystyrene ionexchange resin, phosphonated polystyrene ionexchange resin, and sulfomethylcellulose ion exchanger. I. In vitro experiments : The ion exchangers were shaken in suspension with the solution of radiostrontium in flasks containing calcium salt in several concentrations. Adsorption of radiostrontium by ion exchangers increased with the decrease in the concentration of calcium in the medium. In a medium of physiological concentration (10 m mole) of calcium salt sulfonated polystyrene resin rapidly adsorbed more than 98% of radiostrontium. II. Animal experiments : Sodium, calcium, and strontium forms of the resins were administered to rats, mixed in their diet containing radioactive strontium in the form of calcium strontium carbonate. Calcium form of fulfonated polystyrene resin is the most effective in inhibiting gastrointestinal absorption of radiostrontium. The larger the amount of the resin in the diet, the larger was the amount of radiostrontium in the feces. A diet containing the resin of the calcium form in 40% of the diet inhibited the absorption to the level of 1/2 to 1/8 of the control group.抄録全体を表示PDF形式でダウンロード (945K) -
楢府 直大1967 年 87 巻 6 号 p. 726-731
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーIn the previous work of this series, it was found that bromine atom in bromural, Carbromal, and Acetylcarbromal was reductively removed in rabbits, ureide chain remaining intact. The present experiment was undertaken to obtain further confirmation that this pathway occurs generally in the metabolism of 2-bromoacylureides, using (2-bromopropionyl) urea and (2-bromocaproyl) urea. Rabbits were used as experimental animals, and the urine collected 24 hours after medication was extracted continuously with ethyl acetate. Crude crystals obtained from urine extracts of rabbits were further purified by column chromatography over alumina and identified to be the debrominated metabolites, n-propionyl urea and n-caproylurea. Determination of these metabolites excreted in the 24-urine after medication was carried out by the combination of thin-layer chromatography and ultraviolet absorption spectra. Since the above conversion did proceed in the homogenate of the liver and kidney, but the activity disappeared completely in the boiled homogenates, it was assumed that this debromination had occurred enzymatically. From these findings, in addition to the previous ones, it may be concluded that this reductive debromination is a metabolic process occurring generally in (2-bromoacyl) ureides.抄録全体を表示PDF形式でダウンロード (769K) -
安江 政一, 河村 典久, 加藤 武1967 年 87 巻 6 号 p. 732-735
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーThe constituents of fallen leaves of Evodiopanax innovans NAKAI were examined and following substances were detected (yield%) : Maltol (0.12), rhoifolin (1.13), naringin (0.11), and a new compound innovanamine (2.2). The sturcture of innovanamine was suggested as 2-methyl-3-β-D-glucopyranosyloxy-4 (1H)-pyridone. Taraxerol and taraxerone were isolated from the methanol extract of its bark.抄録全体を表示PDF形式でダウンロード (571K) -
大井 尚文1967 年 87 巻 6 号 p. 736-738
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーAn infrared spectrophotometric method is proposed for a rapid determination of a small amount of β-naphthol in α-naphthol or α-naphthol in β-naphthol, by the use of a compensation technique. Carbon disulfide is chosen as a solvent in both cases, and key bands used for β-naphthol and α-naphthol are 743 and 768 cm-1, and each component can be determined up to 0.1% and 0.5%, respectively. It was clarified that the absorption intensities of the CH out-of-plane bending bands in β-naphthol were influenced by the formation of an intermolecular hydrogen bonding.抄録全体を表示PDF形式でダウンロード (448K) -
大井 尚文, 宮崎 慧一郎1967 年 87 巻 6 号 p. 739-741
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーAn infrared spectrophotometric method is offered for rapid determination of small amount of isopropamide in pharmaceutical preparation containing aminopyrine, phenacetin, caffeine, and isopropamide, by the use of compensation method. Acetone was chosen as a solvent, the key band used for isopropamide was 702 cm-1, and the solution of aminopyrine and phenacetin mixture was used as compensation solution. This method gave good results both in standard mixed samples and unknown samples, and it is very useful for routine analysis with simple operation.抄録全体を表示PDF形式でダウンロード (453K) -
大井 尚文, 稲葉 栄司1967 年 87 巻 6 号 p. 741-743
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーSolubilization technique by the use of a high molecular weight amine was applied for qualitative and quantitative infrared spectrophotometric analyses of some water-soluble azo food dyes (Amaranth, Ponceau SX, New Coccine, Orange I, Sunset Yellow). These dyes in aqueous solutions are extracted with a 5% solution of Amberlite LA-2 in carbon disulfide. Each of these dyes was identified easily by their characteristic bands (Table I). The results obtained in the analyses of synthetic mixed samples of Amaranth and Ponceau SX indicated that this method would be useful for quantitative determination (Table II).抄録全体を表示PDF形式でダウンロード (491K) -
赤外線吸収スペクトルによる医薬品の分析研究(第13報) : 650～400cm-1(KBr領域)におけるアミノピリン, フェナセチン, カフェイン混合製剤中のフェナセチンおよびカフェインの迅速同時定量大井 尚文, 稲葉 栄司1967 年 87 巻 6 号 p. 743-745
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーA new and simple infrared spectrophotometric method using 650∼400 cm-1 (KBr) region offered for rapid simultaneous determination of phenacetin and caffeine in their pharmaceutical preparations containing aminopyrine. The separation of absorption bands of these components is better than in ordinary NaCl region. The key bands used for phenacetin and caffeine are 543 and 483 cm-1, respectively, in CHCl3 solution, and these two components are easily determined without interferences of other components by the use of suitalbe base lines. This method gave good results in standard mixed samples and unknown samples.抄録全体を表示PDF形式でダウンロード (419K) -
林 英作, 名倉 猛夫1967 年 87 巻 6 号 p. 745-746
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーWhen acridine (I) is dissolved in propionaldehyde (II) and the solution is allowed to stand for a few days at room temperature, 2-(9-acridanyl) propionaldehyde (III) is formed. This reaction does not take place with acetaldehyde, butyraldehyde, and isobutyraldehyde. Application of chloranil to III results in the formation of 9-acridinyl methyl ketone (V) but the route of its formation is not clear.抄録全体を表示PDF形式でダウンロード (303K) -
竹本 常松, 小川 俊太郎, 西本 喜重, 平山 瞳, 谷口 忍1967 年 87 巻 6 号 p. 748
発行日: 1967/06/25
公開日: 2008/05/30
ジャーナル フリーPDF形式でダウンロード (239K)
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