YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
93 巻, 12 号
選択された号の論文の25件中1~25を表示しています
  • 安茂 寿夫, 和志武 三徳, 林 英文
    1973 年 93 巻 12 号 p. 1545-1553
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Decomposition of L-ascorbic acid with and without D-araboascorbic acid in the aqueous solution was studied in atmospheric condition. Experiments were carried out using cylindrical glass vessels. At each pH, the logarithm of the residual percentage of L-ascorbic acid was found to have a rectilinear correlation with time, and the decomposition rate constant of L-ascorbic acid decreased with increase in the concentration of L-ascorbic acid. Even on varying the liquid height of L-ascorbic acid solution in the same diameter vessels, a rectilinear correlation was also observed between both logarithms of the liquid heights and of the rate constants of L-ascorbic acid in the pH range from 2.4 to 6.0. By extrapolation of the regression lines, the pH-rate profile at the liquid height of 1 mm was obtained. From kinetical studies, it was also found that a complex between undissated form and monohydrogen ascorbate play some role in a series of decomposition processed under the atmospheric condition as well as under the anaerobic condition. In the case of the same initial concentration of L-ascorbic acid and D-araboascorbic acid, a considerable difference was not recognized between the rate constants of the decomposition of L-ascobic acid and of D-araboascobic acid, respectively. Further, it was recognized that the rate constant of L-ascorbic acid (or D-araboascorbic acid) in the mixture of L-ascorbic acid and D-araboascorbic acid is approximately equal to the rate constant of L-ascorbic acid at the same concentration to the total concentration of both acids. Thus, L-ascorbic acid was stabilized in the presence of D-araboascorbic acid. It can be reasonably concluded that observed stability increase of L-ascorbic acid dose not depend on the anti-oxidizing effect (the preferably oxidized) by D-araboascorpic acid, but is merely based on the effect by the increase of the total concentration of both acids.
  • 豊吉 一美, 森 幸雄, 馬場 茂雄
    1973 年 93 巻 12 号 p. 1554-1557
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The species differences in the metabolism of the carcinogenic azo dye, 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB), by the liver of rats, mice, and hamsters were studied by the tracer method. 3'-Me-DAB[5'-3H] was incubated with the liver homogenate of each experimental animal, and 72-75% of the radioactivity added was recovered in the benzene-acetone (1 : 1) layer from the incubation mixture. The substrate and metabolites in the extracts were separated and isolated by preparative thin-layer chromatography on silica gel plates and identified by the reverse isotope dilution analysis. The overall detoxication activity of this carcinogen in mouse liver was the highest and that of hamster liver was similar to that of rat liver. In these normal livers the azo-reduction was the main ditoxicative metabolism of 3'-Me-DAB, and the azo-reduction activity of hamster liver was the lowest, while the actvvity of mouse or rat liver was about two or three times greater.
  • 藤川 福二郎, 平山 晃久, 森 友昭, 中村 美智子, 高垣 由紀子, 元田 陽子, 向仲 寿子, 伊藤 和子, 松居 玲子, 藤沢 美江
    1973 年 93 巻 12 号 p. 1558-1563
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Total nitrogen and amino acids were determined in 44 kinds of Japanese lichens ; the former by the semimicro-Kjeldahl method and the latter by amino acid analyzer (Hitachi Model KLA-2). The number of amino acids detected in these lichens was 10 at the minimun and 20 at the maximum. As in the previous work, content of alanine and glutamic acid was larger than those of other amino acids in the present 44 kinds of lichens ; those containing more than 100μmole/100g of lichen being ca. 40.91% for alanine and ca.16.64% for glutamic acid. Summarizing the total of 144 kinds of lichens reported in parts I to III, lichens containing more than 100 μmole/100g, were ca.45.2% for alanine and ca.17.4% for glutamic acid. Quantitative determination of amino acids was made with Dermatorcarpon miniatum (L.) MANN and it was found to contain the highest amount of giycine, asparticacid, proline, arginine, lysine, methionine, and cysteic acid, next highest content of leucine, serine, threonine, glutamic acid, histidine, and taurine, and third highest content of alanine and valine among the 144 kinds of lichens examined. This lichen contained a total of 18 kinds of amino acid and, together with the above high contents, this lichen must be a unique one. Amino acid-nitrogen, calculated from the analytical values of amino acids, became ca.0.2% against total nitrogen value of 2.32%, and the remaining ca. 91.19% must be due to other nitrogen-containing compounds. Total nitrogen was especially high in 2 kinds of Peltigera and 1 kind of Sticta. Total nitrogen of 4.47% was found in Leptogium tremelloides S. GRAY var. azureum NYL., which is second to 4.52% in Peltigera variolosa (MASS, ) GYEL., and 10 of 18 kinds of amino acid contained were in more than 100mole/100g of this lichen. Other lichens of Leptogium sp. may also show the same result and this lichen is also an interesting one. It was also of interest that 8 kinds of Usnea sp. contained taurine. The lichens examined were found to contain a few kinds of Ninhydrin-positive substance, other than amino acids constituting the protein, as was found in previous work, but the substances were not examined further.
  • 小橋 恭一, 竹部 幸子, 長谷 純一
    1973 年 93 巻 12 号 p. 1564-1572
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Hydroxamic acid has been known to inhibit urease activity of gastrointestinal tract and decrease the level of blood ammonia. Using caprylo-and nicotinohydroxamic acid-[carbonyl-14C] which are potent inhibitors of urease activity, distribution, metabolism and excretion of the compounds were studied after their oral administration to rats and guinea pigs. Caprylohydroxamic acid was rapidly hydrolyzed by liver homogenate to caprylic acid and hydroxylamine, and hydroxamic acid was not detected in any tissues except in gastrointestinal tract 2 hr after its administration. Radioactivity derived from hydroxamic acid was found in the liver and heart in considerable amounts, but most of total radioactivity was axcreted by expiration as CO2 and several percentage was excreted in urine within 24 hr. Nicotinohydroxamic acid was slowly decomposed by liver homogenate and a small amount of hydroxamic acid remained in the tissues 2 hr after its administration. Radioactivity derived from hydroxamic acid was observed considerably in the liver and kidney, and widely distributed in other tissues. Half of total radioactivity was excreted in urine and a few percentage as CO2 within 24 hr. A part of the radioactivity was retained in the body and excreted gradually only in urine. Pattern of metabolites of nicotinohydroxamic acid in urine was similar to those of nicotinamide already reported.
  • 立川 四郎, 竹中 登一
    1973 年 93 巻 12 号 p. 1573-1580
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    1) The β-blocking and direct effect on heart rate of six newly synthesized indene derivatives was studied in reserpinized rats and compared with that of propranolol (PROP), alprenolol(ALP), USVC 6524(USVC), practolol(PRACT)and YB-2. The order of potency of 1-(7-indenyloxy)-3-alkylaminopropan-2-ol derivatives(I-IV) antagonizing isoproterenol-induced tachycardia was III (tert. butyl)>YB-2 (isopropyl)>II (sec butyl)>I(isobutyl)>IV (cyclohexyl). Especially, III and YB-2 were 2.5 and 1.5 times more potent than PROP, respectively. The activity of 1-(3-methyl-7-indenyloxy)-3-isopropylaminopropan-2-ol(V)and 1-(3-methyl-4-chlor-7-indenyloxy)-3-isopropylaminopropan-2-ol(VI) was much weaker than that of YB-2. 2) In the same preparations, I-IV, VI, YB-2, and ALP showed a moderate intrinsic sympathomimetic activity (ISA), while the compound (V) exhibited a marked ISA comparable to that of PRACT 3) YB-2 and ALP in concentration of 5×10-8g/ml depressed the motility of the isolated rat uterus, while PROP and USVC were devoid of such inhibitory effect, indicating a lack of ISA in these corn : unds. 4) All indene derivatives, in concentration of 1% or less showed a local inesthetic action in the guinea pig cornea. 5) Comparison of the KB values in the left atrium and trachea isolated from guinea pigs indicated that III and ALP possessed a greater affinity for the tracheal smooth muscle than for the atrium, whereas YB-2 and PROP blocked β-receptors in both organs to the same degree.
  • 木本 正七郎, 岡本 正夫, 川端 哲郎, 太田 俊作
    1973 年 93 巻 12 号 p. 1581-1584
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reactions of 2, 3-diaminoisocarbostyril with acetyl chloride, acetic anhydride, and benzoyl chloride, in the presence or absence of bases such as pyridine and triethylamine, were examined. In order to see whether acylation took place at the β-position of the enamine (C4 of 3-aminoisocarbostyril) or the other positions, comparison of ultraviolet absorption was found to be a valuable tool.
  • 野上 寿, 花野 学, 粟津 荘司, 今岡 キク子
    1973 年 93 巻 12 号 p. 1585-1592
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The excretion time courses of sulpyrin and its metabolites, 4-monomethylamino-antipyrine (I), 4-aminoantipyrine (II), and 4-acetylaminoantipyrine (III), in rat urine were determined after intravenous administration of sulpyrine (10 μmole/head). Since the total recovery of sulpyrin and its metabolites from urine was about 67%, the unknown process of sulpyrin metabolism had to be presumed. With the results of excretion time courses of the metabolites after the intravenous administration of sulpyrin metabolites, I, II and III, the unknown route was regarded as the elimination of sulpyrin itself or the metabolism of II. Based on each rate constant obtained from these two pharmacokinetic model, the time courses of the amount of sulpyrin and its metabolites in rat were calculated.
  • 野上 寿, 花野 学, 粟津 荘司, 今岡 キク子
    1973 年 93 巻 12 号 p. 1593-1602
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The effect of dose of sulpyrine on the excretion and metabolism rates was studied after the intravenous administration of sulpyrin in rat. Ten, 40 and 100 μmole/head doses were used. The excretion in urine of sulpyrine and its metabolites, 4-monomethylamino-antipyrine (I), 4-aminoantipyrine (II), 4-acetylaminoantipyrine (III), 4-hydroxyantipyrine (IV) and its conjugate (V) was examined for each dose. The differences in the time conurse with dose were studied statistically, with t-test for cumulative excretion data at each time and with F-value for the average vector of the time course. Significant differences were observed in excretion of sulpyrin, II and III for doses of 10-40 μmole and 10-100 μmole. Pharmacokinetic analyses were carried out for excretion of sulnyrin and its metabolites both for 10 and 40 μmole doses to elucidate the dose dependecy. As a result, the rate constants of elimination of sulpyrine (k1), elimination of II (k4), and metabolism of II other than the route to III (k5) were found dose dependent. When the dose mcreased from 10 to 40 μmole, k1 increased to produce a rapid excretion of sulpyrin itself, and k4 and k5 creased to cause a higher excretion of III. Since some discrepancy was observed, for the pharmacokinetic behaviors of IV and V, between administration of sulpyrin and IV itself, a clear kinetic analysis was not successful and dose dependency was not studied in detail.
  • 野上 寿, 花野 学, 粟津 荘司, 今岡 キク子
    1973 年 93 巻 12 号 p. 1603-1610
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    After intravenous, intramuscular, or oral administration of sulpyrin (10, 100μmole/head) to rats, sulpyfrin, 4-monomethylaminoantipyrine, 4-aminoantipyrine and 4-acetylaminoantipyrine excreted in urine were determined successively. Based on these data, the absorption rate was estimated and the change of sulpyrin metabolism with the administration route was investigated. Between intravenous and intramuscular injection, the average value of the urinary excretion of sulpyrin+4-monomethylaminoantipyrine was smaller, in the latter but there was no significant difference between them. In contrast, a remarkable decrease was recogdized both in the amount and rate of excretion in the case of oral administration, and it was considered that the absorption of sulpyrin in the digestive tract was slow and sulpyrin was decomposed during its absorption. The excretion of 4-aminoantipyrine was significitly delayed in the case of intramuscular injection compared with initravenous injection. The excretion of 4-acetylaminoantipyrine increased in the order of intravenous, intramuscular, and oral administration. It was found that the metabolism of sulpyrin changed with administration route. The estimation of absorption rate of sulpyrin by convolution method using the excretion data of sulpyrin+4-monomethylaminoantipyrine showed that the absorption ended in 1 hr after the intramuscular injection, but it continued more than 5 hr atter the oral administration. It was found that sulpyrin was partly decomposed when it was absorbed both in intramuscular and oral administration. The decompose substance was considered to be also absorbed and to be excreted in urine as 4-aminoantipyrine and 4-acetylaminoantipyrine by metabolism.
  • 伊藤 一男, 古川 宏, 春名 光昌
    1973 年 93 巻 12 号 p. 1611-1616
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The alkaloidal components of the leaves and leaf stalks of Erythrina arborescens ROXB. (Leguminosae) were examined. The known Erythrina alkaloids, erysodine (I), erysotrine (X), and erythratidine (VI), a tetrahydrobenzylisoquinoline alkaloid, N-nororientaline (XIV), and a dibenz[d, f]azonine alkaloid, erybidine (XV), were isolated and identified. In addition, three new non-phenolic bases, which were named erytharbine (XVI), erysotramidine (XVII), and 1-1-hydroxyerysotrine (XVIII), were isolated and characterized.
  • 伊藤 一男, 古川 宏, 春名 光昌
    1973 年 93 巻 12 号 p. 1617-1621
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Erysotramidine, erytharbine, and 11-hydroxyerysotrine are three new Erythrina alkaloids, which have been isolated from Erythrina arborescens ROXB. (Leguminosae) along with erysodine (IV), N-nororientaline (V), erybidine (VI), erysotrine (VII) and erythratidine (VIII). Chemical and spectral investigations have been shown that erysotramidine, erytharbine, and 11-hydroxyerysotrine have the stereostructures (I), (II) and (III), respectively. It is interesting that the isolation of srysotramidine and erytharbine. from this plant is the first examples of the natural Erythrina alkaloids containing an amide group.
  • 藤田 真一, 藤田 安二
    1973 年 93 巻 12 号 p. 1622-1626
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The essential oil of Schizomepeta tenuifolia BRIQ. was examined in detail. The yield of the oil was 0.43-0.45% from the fresh herbs and the oil contained α-pinene, camphene, β-pinene, d-limonene, 3-octanone, p-cymene, 3-octanol, 1-octen-3-ol, 3-methylcyclohexanone, d-menthone, l-isomenthone, β-elemene, caryophyllene, isopulogone, β-humulene, l-pulegone, piperitone, piperitenone, and other unidentified compounds, together with a small amount of the secondary products from pulegone and menthone ; d-menthofuranoxide, dehydroxymenthofuranoxide, β-methyladipic acid, and β-methyl-δ-isobutyry1va1eric acid.
  • 今枝 一男, 栗木 武男
    1973 年 93 巻 12 号 p. 1627-1634
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Oxygen in arsenic and various arsenic compounds was determined by Schutzo-Unterzaucher method. When the determination of oxygen in arsenic compounds was repeated 5 or 6 times by the method using platinum-carbon, the activity of platinum-carbon deteriorated. The analytical values of arsenic trioxide were less than the theoretical value by about 1%. When nickel-carbon was used in place of platinum-carbon, the deterioration was less than that of platinum-carbon. When the determination of oxygen in arsenic trioxide was repeated 17 times, the analytical values of sucrose and phenolphtalein were less than the theoretical value by about 1%. However, it was not advisable to use nickel-carbon for the routine analysis. The experiment using two-layer packing of either carbon-platinum-carbon or nickel-carbon-nickel-carbon did not give good results. Determination using carbon pretreated with hydrogen and heated at above 1030° was found possible with an error of 0.2%. One analysis required approximately 35 min.
  • 藤田 治重, 山下 正太郎
    1973 年 93 巻 12 号 p. 1635-1638
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    To elucidate the constituents of the essential oil from Alpinia speciosa K.SCHUM, the plant grown in groups at Nago (Okinawa Prefecture) was collected and the essential oil obtained by steam distillation of the leaves and stems was separated into three parts (neutral, phenolic, and carboxylic acid) by a chemical method. The products were investigated by the aid of instrumental analysis (gas-liquid chromatography, infrared, and nuclear magnetic resonance) and 46 kinds of compound (methyl cinnamate, etc.) besides the known four kinds (camphor, etc.) were newly detected.
  • 大和 正利, 佐藤 浩一, 橋垣 国子, 石川 忠興, 小山 鷹二
    1973 年 93 巻 12 号 p. 1639-1642
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Further investigation was made on the derivatives of β-(3-hydroxy-4-methoxyphenyl)-ethylbenzene which is regarded as the essential structure for the sweet taste of phyllodulcin, and compounds (II-XIII) were synthesized. Both VIII and XI were sweet, whereas II, III, and IV were tasteless, and V, VI, VII, IX, X, and XII revealed a bitter taste. On the basis of these data, a delicate relationship between the molecular structure and sweet taste receptor site was presumed.
  • 坂本 正徳, 柴野 美智子, 富松 祥郎
    1973 年 93 巻 12 号 p. 1643-1646
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reaction of furazan derivatives with anethole (IV) was carried out with a view to establishing the structure-reactivity relationship of the 1, 4-diaza-1, 3-butadiene system. While benzofuroxan (III) reacted with IV giving 2-(p-methoxyphenyl)-3-methylquinoxaline 1, 4-dioxide (VII) through 1, 4-cycloaddition with loss of hydrogen, reaction of diethyl furoxandicarboxylate (XIV) with IV, contrary to expection, gave ethyl 4-methyl-5-(p-methoxyphenyl) isoxazole-3-carboxylate (XVI). In the latter case, it was thought that the formation of XVI is probably due to thermal decomposition of XIV to nitrile oxide (XV), following the addition of IV to XV and dehydrogenation.
  • 浅田 昌三, 中里 辰雄, 滝野 貞子
    1973 年 93 巻 12 号 p. 1647-1654
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    A relationship between the acid dissociation constants of arylsulfonylurea deriyatives and the Hammett equation was examined quantitatively. 1) Acid dissociation constants of 60 compounds were determined at 20° and in an ionic strength of 0.2. 2) A good, linear relationship between log KNH and σ (or Σσ) was obtained except for several compounds. 3) A modified Hammett relationship (Eq.6) for nucleophilic reactions can be applied to the acid dissociation of N2-phenyl-N1-p-aceto-or-p-nitrobenzenesulfonylurea and its derivatives.
  • 有澤 宗久, 森田 直賢, 近藤 嘉和, 竹本 常松
    1973 年 93 巻 12 号 p. 1655-1659
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    β-Sitosterol and its glucoside were isolated from the rhizoma of Iris florentina L., and were identified by direct comparison with an authentic samples. Embinin and swertisin were isolated from the petals of Iris japonica THUNB. (Iridaceae), and were identified by direct comparison with authentic samples. The structure of embinin is now revised to 7, 4'-dimethyl-apigenin-6-C-β-D-glucopyranosyl-2"-O-L-rhamnoside (=embigenin-2"-L-rhamnoside) on the basis of its nuclear magnetic resonance data.
  • 柴田 丸, 吉田 玲子, 本橋 幸子, 福島 正子
    1973 年 93 巻 12 号 p. 1660-1667
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Crude saikosides did not affect the LD50 value of sodium hexobarbital in mice. It also exerted a protective effect on the pylorus-ligated ulcer of the rat with inhibiting gastric secretion. The cure of chronic ulcer produced by the injection of dilute acetic acid into the rat gastric wall was promoted by crude saikosides. Saikogenin A showed a potent effect of decreasing spontaneous motor activities of the mice treated with methamohetamine hydrochloride. It had a significant antitussive, hypothermic, and antipyretic effect, and inhibition of acetic acid-induced writhing responses. In addition, salikogenin A strongly reduced a carrageenin-induced rat paw edema, without any local irritaition by topical application. On the contrary, only analgesic effect was found in the syrupy residue. The significance of these pharmacological results was discussed.
  • 安江 政一, 榊原 仁作, 柳沢 いく子
    1973 年 93 巻 12 号 p. 1668-1670
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Toxic principles of the leaves of Rhododendron japonicum were isolated and identified as rhodojaponin-I and -II. Other substances, normal saturated aliphatic higher hydrocarbons, alcohols, and aldehydes, β-sitosterol and its β-D-glucoside, quercetin, quercitrin, ursolic acid, maslinic acid, and coumarin were also isolated.
  • 伊藤 一男, 古川 宏, 春名 光昌, 盧 盛徳
    1973 年 93 巻 12 号 p. 1671-1674
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    The alkaloidal components of the leaves of Formosan Erythrina orientalis (L.) MURE. (Leguminosae) were examined and two tetrahydroprotoberberine alkaloids, scoulerine (XI) and (+)-coreximine (XII), a benzyltetrahydroisoquinoline alkaloid, L-reticuline (XIV), and a dibenz[d, f]azonine alkaloid, erybidine (XV), were isolated and respectively identified.
  • 伊藤 一男, 古川 宏, 春名 光昌, 伊藤 みな子
    1973 年 93 巻 12 号 p. 1674-1678
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    From the leaves, trunks, and roots of Erythrina crysta-galli cv. Maruba Deiho H. MURATA. (Leguminosae), a benzultetrahydroisoquinoline alkaloid, N-nororientaline (XI), a dibenz[d, f]azonine alkaloid, erybidne (XII), three Erythrina alkaloids of spiroamine type, erythraline (IV), erythrinine (XIII), and erythratine (VII), were isolated and characterized.
  • 藤田 真一, 藤田 安二
    1973 年 93 巻 12 号 p. 1679-1681
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Agasiache rugosa O.KUNTZE, collected in Kitami, Hokkaido, afforded 0.14% oil from the fresh herbs and 0.24-0.39% oil from the dry herbs, and the oil contained 83.5-92.2% of methyleugenol, 1.5-6.3% of methylchavicol, and 0.1-0.4% of safrole, together with small amonts of α-pinene, β-pinene, limonene, 3-octanone., p-cymene, 3-octanol, cis-β, γ-hexenol (?), 1-octen-3-ol, linalool, β-element, caryophyllene, humulene, δ-cadinene, and other unidentified compounds. Compared with the ordinary A. rugosa O.KUNTZE, which afford the essential oil containing as much as 96.3% of methylchavicol, this plant collected at Kitami may be a new variety of the normal one.
  • 松浦 信, 李 連滋, 飯沼 宗和
    1973 年 93 巻 12 号 p. 1682-1684
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Arachidic acid, behenic acid, β-sitosterol, β-sitosteryl-β-D-glucoside, physcion, emodin, ursolic acid, and compound (F) were isolated from the roots of Boehmeria platanifolia FRANCH. et SAN., and these compounds except substance (F) were identified with authentic samples.
  • 加藤 鉄三, 山本 豊, 近藤 正嗣
    1973 年 93 巻 12 号 p. 1685-1687
    発行日: 1973/12/25
    公開日: 2008/05/30
    ジャーナル フリー
    Synthesis of 2, 6, 8-trimethylpurine (VIII) and 2, 5, 7-trimethyloxazolo[5, 4-α]pyrimidine (IV) from 5-acetyl-2, 6-dimethyl-4(3H)-pyrimidone (I) in three steps involving Bechmann rearrangement was carried out. Also, 3, 4, 6-trimethyl-1H-pyrazolo[3, 4-d]pyrimidine (IX) and 2, 4, 5, 7-tetramthylpyrimido[4, 5-d]pyrimidine (X) were prepared from I.
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