Syntheses of 2-naphthalenealkylamine derivatives, whose carbon number (
n) of the alkyl group was varied from
n=0-7 and
n=10 (IIIa-XIa), and their N, N-dimethyl derivatives (IIIb-XIb) as well as their methiodide (IIIc-XIc) were carried out in order to examine their pharmacological activities.
Anti-acetylcholine activities and anti-histamine activities were tested according to the Magnus method. Both activities showed a tendency to strengthen as the carbon number of alkyl group increased. However, the anti-acetylcholine activities of primary amine, whose
n is 10, was observed to be a little lower than that of the amine of
n=7. As to the anti-histamine activities, dimethylamino derivative of
n=2 was found to be the strongest, that of 3 and 4 were weaker and it became stronger as the carbon number increased. The activities of methiodide of
n=1 was a little stronger than that of
n=2 in both activities.
As to the blood pressure activities of primary amines,
n=0 showed depression and
n=1-4 showed, after a little depression, a rise type, whose degree was observed to be the maximum with
n=2 and later weakened to a depress type. Dimethyl compounds were depressive andmethiodide showed usually a continuous rise, after the depression.
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