巻号一覧
103 巻, 8 号
選択された号の論文の14件中1～14を表示しています
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藤井 信孝1983 年 103 巻 8 号 p. 805-818
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーIn peptide synthesis, any desired peptide can not be obtained in a satisfactory yield and with a high degree of purity, without having a suitable deprotecting tool at the final stage of the synthesis. Moreover, the choice of a final deprotecting reagent determines the main synthetic strategy. In order to explore the suitable deprotecting conditions, the methanesulfonic acid and trifluoromethanesulfonic aoid deprotecting procedures have been examined. After investigating a few of side reactions which can take place under the above deprotecting conditions, the validity of these deprotecting reagents was demonstrated by the syntheses of several biologically active polypeptides including bovine pancreatic ribonuclease (RNase) A. The scope and limitation of these organosulfonic acid deprotecting reagents in peptide synthesis are discussed in this review.抄録全体を表示PDF形式でダウンロード (1175K) -
西庄 重次郎, 竹中 富美子1983 年 103 巻 8 号 p. 819-824
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーThe formation of solid complex of theophylline and aliphatic organic dibasic acid was tried in aqueous solution. Consequently, solid complexes were formed from theophylline with oxalic acid in a molar ratio of 2 : 1, and with maleic acid, malonic acid and glutaric acid in a molar ratio of 1 : 1. However, no solid complexes with succinic acid or adipic acid were formed. The type of bonding of theophylline with an organic dibasic acid was considered to be an intermolecular hydrogen bond between the carboxyl group of the organic acid and nitrogen at the 9-position of theophylline. The reasons that 1 : 1 complexes tend to be formed were presumed. With a decrease in pKa, organic acid had a tendency to be stabilized thermally by the formation of its solid complex and the heat of reaction to form solid complex from crystals of its component also increased except maleic acid.抄録全体を表示PDF形式でダウンロード (581K) -
武田 秀雄, 藤田 浩毅, 室賀 慎二, 鈴木 稠徳, 久道 周彦1983 年 103 巻 8 号 p. 825-834
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーTwenty-four derivatives of 4-(2-dialkylamino-1-phenylethyl)-2H-pyrido [3, 2-b]-1, 4-oxazin-3-one (8a-13d) were synthesized, and then obtained as hydrochloride. The following results were obtained by the preliminary investigation on the local anesthetic and the analgesic (mouse writhing test) activities of these synthesized compounds. All these compounds had no surface anesthetic activity, and weaker infiltrative one than that of lidocaine ; the analgesic action of almost all these compounds was superior to that of aspirin.抄録全体を表示PDF形式でダウンロード (766K) -
武田 秀雄, 室賀 慎二, 藤田 浩毅, 久道 周彦, 鈴木 稠徳1983 年 103 巻 8 号 p. 835-848
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーTwenty-four derivatives of 4-(2-dialkylamino-1-phenylethyl)-3, 4-dihydro-2H-pyrido [3, 2-b]-1, 4-oxazine (15a-20d) were synthesized, and then obtained as hydrochloride. The following results were obtained by the preliminary investigation of the local anesthetic and the analgesic (mouse writhing test) activities of these synthesized compounds. All these compounds have little surface anesthetic activity and weaker infiltrative one than that of lidocaine ; some of them have the analgesic action superior to that of aspirin.抄録全体を表示PDF形式でダウンロード (857K) -
武田 秀雄, 藤田 浩毅, 室賀 慎二, 鈴木 稠徳, 久道 周彦1983 年 103 巻 8 号 p. 849-856
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーEighteen derivatives of 4-phenylalkyl-2H-pyrido [3, 2-b]-1, 4-oxazin-3-one (8a-13c) were synthesized, and then obtained as hydrochloride. The following results were obtained by the preliminary investigation on the local anesthetic and the analgesic (mouse writhing test) activities of these synthesized compounds. All these compounds have little local anesthetic activity ; the analgesic action of these compounds was approximately equivalent to or slightly weaker than that of aspirin.抄録全体を表示PDF形式でダウンロード (655K) -
武田 秀雄, 室賀 慎二, 藤田 浩毅, 久道 周彦, 鈴木 稠徳1983 年 103 巻 8 号 p. 857-866
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーEighteen kinds of 4-phenylalkyl-3, 4-dihydro-2H-pyrido [3, 2-b]-1, 4-oxazine derivative (14a-19c), and their hydrochlorides were synthesized. The preliminary investigation on the local anesthetic and the analgesic (mouse writhing test) activities of these synthesized compounds was carried out. All these compounds had no surface anesthetic activity and had a slight infiltration inferior to that of lidocaine : some of them have the analgesic action approximately equivalent to that of aspirin. It was proved that all these compounds have little acute toxicity.抄録全体を表示PDF形式でダウンロード (667K) -
古家 義朗, 林田 真司, 冨山 昌美, 大塚 宣文, 上田 甫1983 年 103 巻 8 号 p. 867-870
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーEthyl β-anilinocrotonate was given by the reversible reaction of ethyl acetoacetate with aniline in the presence of sulfuric acid in methanol at 35°C. The reactions were followed by spectrophotometry and the following rate equation for the forward reaction was obtained. Rateforward={(k2AE-k3AAECA)+(k3AEE-k4AAEECA) CE} CACE The four rate constants contain the acidity term of the reaction medium and were governed by the activation entropy. Furthermore, an increase in aniline concentration hinders the rate for this reaction. From these findings, a probable reaction mechanism is discussed and illustrated.抄録全体を表示PDF形式でダウンロード (458K) -
久保 道徳, 松田 秀秋, 野上 真里, 有地 滋, 高橋 猛1983 年 103 巻 8 号 p. 871-877
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーEffects of aqueous extract of Ganoderma lucidum, collected in Kyoto (K) and Odawara (O), on the experimentally disseminated intravascular coagulation (DIC) in rats were investigated. K prevented the decreases of blood platelet and fibrinogen, the prolongation of prothrombin time and the increase of fibrin degradation products (FDP) at a dose of 500 mg/kg in normal rats on DIC induced by endotoxin. O prevented the decrease of blood platelet at a dose of 500 mg/kg. K and O prevented the formation of hepatic vein thrombosis induced by endotoxin in hyperlipemia rats. In order to reveal the mode of in vivo action of K and O, the activities of K and O for blood platelet aggregation, thrombin action and fibrinolytic action were examined in vitro. K and O showed inhibitory effects on blood platelet aggregation induced by collagen, and on thrombin action at concentrations of 500-1000 μg/ml.抄録全体を表示PDF形式でダウンロード (1130K) -
市川 哲生, 寺田 弘1983 年 103 巻 8 号 p. 878-883
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーIn these days, derivative spectrophotometry by using the convolution operation is often used with the development of microprocesser-controlled spectrophotometer. This article deals with the relationship between (characteristics of) derivative band and data-processing span on the convolution operation. operation. Distortion errors for main bands and satellite bands in second derivative curves were computed by use of Gaussian and Lorentzian curves as models of absorption spectra. These results were compared with some experimental absorption spectra of amino acids.抄録全体を表示PDF形式でダウンロード (616K) -
松原 チヨ, 西川 雄司, 高村 喜代子1983 年 103 巻 8 号 p. 884-888
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーA mixture of Ti (IV) and 4-(2-pyridylazo) resorcinol (Ti-PAR reagent) is found to be useful for the spectrophotometric determination of trace amounts of H2O2. The absorbance at 508 nm was proportional to the concentration of H2O2 added. The reagent was successfully applied to the assay of triglycerides in the serum. Triglycerides are enzymatically hydrolyzed to produce glycerol and fatty acids. The fatty acids were determined by the detection of H2O2 using the Ti-PAR reagent by the combined use of acyl CoA synthetase and acyl CoA oxidase. It was possible to determine triglycerides in 5 μl of serum ranging in concentration from 5 to 600 mg/100 ml. The coefficient of variation was less than 2.5%. The analytical recovery of triglycerides in the human serum was more than 97%. By this method the absorbance was hardly affected in the presence of reducible substances such as CoA and ascorbic acid.抄録全体を表示PDF形式でダウンロード (585K) -
三原 翠, 内山 充, 山根 靖弘1983 年 103 巻 8 号 p. 889-894
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーIn our previous reports, it was assumed that the thiobarbituric acid (TBA) value not only gives the xisting amount of TBA reactive substances, but represents the combined status of tissue peroxidation including several antioxidative factors. For the further confirmation of the above assumption, biological antioxidants ; glutathione, ascorbic acid, or α-tocopherol, were added individually or combined into the reaction vessel of liver homogenate and methyl linoleate hydroperoxide (MLHPO) with TBA. The TBA value of MLHPO was depressed by the addition of glutathione but not influenced by ascorbic acid or α-tocopherol. The combined addition of these antioxidants showed an effective inhibition on the TBA reaction of MLHPO. The TBA reaction of control liver homogenate was strongly inhibited by ascorbic acid, but insignificantly influenced by α-tocopherol. The TBA reaction of CCl4-intoxicated liver homogenate was significantly inhibited by α-tocopherol.抄録全体を表示PDF形式でダウンロード (676K) -
中陳 静男, 小船 新一, 篠田 雅人1983 年 103 巻 8 号 p. 895-898
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリー21-Hydroxylase, 17α-hydroxylase and C17-20 lyase activites on porcine adrenal microsomes were measured by incubation of radioactive steroids with nicotineamide adenine dinucleotide phosphate. [4-14C]-Progesterone, [4-14C]-pregnenolone, [4-14C]-17α-hydroxyprogesterone and [4-14C]-11-deoxycorticosterone were used as a substrate. 21-Hydroxylase and 17α-hydroxylase activities showed the maximum value in 170 mM and 80 mM potassium phosphate buffer (pH 7.5), respectively. Inhibitory effect of carbon monoxide on 21-hydroxylation and 17α-hydroxylation of progesterone by porcine adrenal microsomes was investigated. The degree of inhibition on two hydroxylation reactions differed. The rate of CO to O2 needed for 50% inhibition of the 21-hydroxylase and 17α-hydroxylase activities were 3.22 and 29.1, respectively.抄録全体を表示PDF形式でダウンロード (514K) -
中澤 一治, 竹内 久米司, 向後 博司, 相澤 義雄1983 年 103 巻 8 号 p. 899-905
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーThe change of urinary prostaglandin E (PGE) excretion was studied in experimental glomerulonephritic rats (Masugi nephritis), and the effects of ouabain and chlorothiazide on urinary PGE excretion in nephritic rats were examined. Experimental glomerulonephritis was induced in rats by the intravenous injection of anti-kidney serum obtained from rabbits immunized with the homogenate of rat kidney. The urinary PGE was measured by the bioassay using rat stomach fundus strip. Urinary PGE and urinary electrolytes in nephritic and normal rats were determined. There was positive relationship between urinary PGE and urinary electrolytes in both kinds of rats. The urinary PGE and sodium excretion was increased in nephritic rats by ouabain (10 mg/kg), but not in normal rats. The potassium and chloride excretion was significantly increased in both nephritic and normal rats by ouabain. The diuretic effect of chlorothiazide (15 mg/kg) was more significantly recognized in nephritic rats than in normal rats. But there was little change in urinary PGE excretion by chlorothiazide in both nephritic and normal rats. The reduction of urinary PGE excretion in nephritic rats may be due to a decrease of PGE biosynthesis in the renal medulla and/or a diminished secretion of PGE into renal tubules, both accompanied with the disturbance of glomerular function.抄録全体を表示PDF形式でダウンロード (628K) -
古家 義朗, 冨山 昌美, 藤沢 公志1983 年 103 巻 8 号 p. 906-908
発行日: 1983/08/25
公開日: 2008/05/30
ジャーナル フリーWhen heating a mixture of methyl p-nitrobenzoate and N, N-dimethylbenzylamine in atmosphere of nitrogen at 180-210°C for 6 h, benzyl p-nitrobenzoate was obtained in a high yield, and trimethylamine as a by-product was detected in the gas-phase. The mechanism of the title reaction involves the Menshutkin type quaternization. For benzyl p-nitrobenzoate appears to be formed, considering the formation of benzyl alcohol, and N, N-dimethyl-p-nitrobenzamide and methyl benzyl ether, which are formed from dimethylbenzyl-p-nitrobenzoylammonium methoxide as the precursor, is unreactive with each other.抄録全体を表示PDF形式でダウンロード (385K)
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