YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
73 巻, 11 号
選択された号の論文の34件中1~34を表示しています
  • スルファミンの葉酸生合成阻害とパラアミノ安息香酸, パラアミノグルタミル安息香酸の相互関係
    大村 榮之助, 川島 實
    1953 年 73 巻 11 号 p. 1145-1150
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) L. arabinosusを用いて葉酸生合成に葉酸中間体と思われるpteroic acid, p-aminobenzoylglutamic acid, PABA, pteridine-6-carboxylic acid等を加えたがPABAを除いて殆んど影響がなかつた.
    2) L. arabinosusの菌の葉酸生合成量は必ずしも菌の生育度に比例したい.
    3) スルファミンによつて葉酸の生合成は阻害をうける. その際の阻害点はPABAとグルタミン酸との結合点であろうと考えた.
    4) L. arabinosusがスルファチアゾールで発育半阻害をうける場合, スルファチアゾールに拮抗する強さは葉酸, p-aminobenzoylglutamic acid, PABAの順序である.
    5) 葉酸が必須栄養素であるL. caseiiはスルファミンによつて発育阻害をうけない.
    本研究に当り御鞭撻を賜つた研究所長桑田 智博士に深謝する. また貴重な化合物を御分与下さつた研究員増田亨, 森田, 桂両氏に厚く御礼申し上げると共に実験の援助をして下さつた土岐夏子, 山岸順子両孃に感謝する.
  • プテリジン誘導体の乳酸菌に対する葉酸類似作用とその拮抗性
    大村 榮之助, 桂城 順三, 森田 桂, 土岐 夏子
    1953 年 73 巻 11 号 p. 1150-1154
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    プテリジン環を持つた化合物16種類についてS. faecalis, L. caseiiについて葉酸類似作用ならびに拮抗性をしらべた.
    1) 2-methyl-4,6,7-trihydroxypteridine, 2,4,7-trihydroxy-6-carboxy-4-aminopteroylglutamic acidは葉酸に拮抗性を示す.
    2) methylleucopterin, 2,4,7-trihydroxy-6-pteridine isobutyric acid, leucopterin, xanthopterinは弱いながらS. faecalis菌に葉酸類似作用を示す.
    3) pteroic acid, pteroic acid diethylaminoethyl ester, 6-piperidiniummethyl pteridine iodide等はL. caseii, S. faecalis両菌に200分の1から1i600分の1の葉酸類似作用を示す.
    4) 以上の結果からpteridineの6位の置換体について見るに葉酸, pteroic acid以外を見るとcarboxyl基, acetic acid基以外の大きい分子の結合している方が葉酸類似作用の物質に転移し易いことが推察される.
    5) leucopterinの2位にmethyl基を導入した場合, 6位の置換基が-COOH基のときよりも-CH2COOH基の場合に拮抗を示す.
  • 細菌発育要素としてのパラアミノ安息香酸とパラニトロ安息香酸との相関関係
    大村 榮之助, 川島 實
    1953 年 73 巻 11 号 p. 1154-1158
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Growth of Lactobacillus arabinosus, Leuconostoc mesenteroides, and Escherichia coli was tested by substituting p-nitrobenzoic acid for p-aminobenzoic acid (PABA). With L. arabinosus, it showed approximately 80% the activity of PAPA, 90-98% of PABA with Leuc. mesenteroides, but no difference was found to have been shown with E. coli. The antagonism of p-nitrobenzoic acid against sulfathiazole was found to be about 1/10 that of PABA with L. arabinosus. It was assumed that the above bacteria utilized p-nitrobenzoic acid by reducing it to PABA.
  • キノリンN-オキシドとα-ブロムピリジン及びα-ブロムキノリンとの反応
    武田 健一, 濱元 要
    1953 年 73 巻 11 号 p. 1158-1161
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    N-(α′-Quinolyl)-α-pyridone was obtained by warming quinoline N-oxide and α-bromopyridine on a water bath. The same pyridone was obtained by heating the sodium salt of α-pyridone and α-bromoquinoline at 200° in the presence of copper dust. In a similar manner, N-(α′-quinolyl)-carbostyril was obtained from quinoline N-oxide and α-bromoquinoline. This carbostyril was also obtained by heating the sodium salt of carbostyril and α-bromoquinoline at 200° in the presence of copper dust.
  • 異項環N-オキシドとα-ブロムピリジン及びα-ブロムキノリンとの反応生成物の構造に就いて
    濱元 要, 窪田 種一
    1953 年 73 巻 11 号 p. 1162-1166
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The fact that the compounds (III), (IV), (V), and (VI), obtained by heating the respective sodium salts of α-pyridone and carbostyril with α-bromopyridine or α-bromoquinoline with copper dust are not in ether form (II) but in keto form (III) was proved physicochemically. The absorption maxima in the ultraviolet absorption spectra of these compounds and their medium effect showed the presence of a carbonyl group. The infrared absorption of (VI) also showed a strong absorption at 6.05μ assumed to be due to the carbonyl group of CONRR'. The potentiometric titration values of (III) and (V) indicated that their basicity is quite weak.
  • 水-グリコール, グリコール-ヂエチレングリコール及びヂエチレングリコール-トリエチレングリコール系の比重と屈折率
    石黒 武雄, 加藤 貞武, 佐方 易忠, 赤澤 彌三郎
    1953 年 73 巻 11 号 p. 1167-1168
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Relationship between the concentration and specific gravity, and refractive index were measured in the systems of water-glycol, glycol-diethylene glycol, and diethylene glycol-triethylene glycol. The concentration-specific gravity relationship gave a curve with a very slight bend while the relationship between concentration and refractive index was linear. It was found possible, therefore, to calculate the concentration, x, of each component by the measurement of a refractive index, n, of a mixture of two substances. Following empirical formulae for each system were proposed.
    Water-Glycol: glycol%, x=1006.0n-1341.0.
    Glycol-Diethylene glycol: diethylene glycol%, x=6493.5n-9301.3.
    Diethylene glycol-Triethylene glycol: triethylene glycol%, x=10526.3n-15240.0
  • エチレンクロルヒドリンのアルカリ分解に於ける-新知見について
    石黒 武雄, 加藤 貞武, 小西 〓, 佐方 易忠
    1953 年 73 巻 11 号 p. 1169-1171
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    During the hydrolysis of ethylene chlorhydrin with alkali, the presence of an excessive amount of alkali or amine resulted in their acting as a catalyst and ethylene oxide formed was found to react selectively with glycols rather than with water. Larger the concentration of ethylene chlorhydrin, less was the amount of ethylene glycol formed, with attendant increase in the amount of di-, tri-, and poly-ethylene glycols. Alkaline hydrolysis of ethylene chlorhydrin solution, added with ethylene or diethylene glycol results in the larger formation of a higher diethylene or triethylene glycol. The larger the amount of glycol added, larger was the amount of diethylene glycol formed, with attendant decrease in the amount of glycol formed from chlorhydrin.
  • 樹皮より二成分の分離
    塚本 赳夫, 富永 敏夫
    1953 年 73 巻 11 号 p. 1172-1175
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    From the 70% alcoholic extract of the air-dried bark of Engelhardtia formosana Hay, yellow plates or needles, m.p. 177-180° (yield, 5.66-7.56%), and colorless needles, m.p. 295-296° (yield, 0.10-0.11%) were isolated and they were respectively designated as Glycoside A and Glycoside B. Hydrolysis of the Glycoside A yielded l-rhamnose and two kinds of aglycones, yellow needles, m.p. 276-277°, and colerless silky needles, m.p. 231-232°, which were respectively designated as Aglycone A and Aglycone B. Aglycone A corresponds to the formula C15H10O5 and gives a tetraacetate, C15H6O6(COCH3)4, of m.p. 182°, a trimethyl ether, C15H7O3(OCH3)3, of m.p. 146° by diazomethane (giving an acetate, C15H6O3(OCH3)3(COCH3), of m.p. 170°), and a tetramethyl ether, C15H6O2(OCH3)4, of m.p. 157° with a large excess of diazomethane or by the application of dimethyl sulfate and 30% potassium hydroxide at a room temperature. Aglycone A was proved to be identical with 3, 5, 7, 4′-tetrahydroxyflavone (kaempferol), m.p. 277°, by mixed fusion with the sample prepared by the method of Robinson-Shinoda. Application of diazomethane to 5, 7-dihydroxy-3, 4′-dimethoxyflavone (III) yielded 5-hydroxy-3, 7, 4′-trimethoxyflavone (IV), m.p. 146-147° (giving an acetate of m.p. 170°) whose further methylation with dimethyl sulfate and alkali yielded 3, 5, 7, 4′-tetramethoxyflavone (V), m.p. 157°. (IV) was found to be identical with the trimethyl ether, and (V), with tetramethyl ether, obtained from Aglycone A.
  • アグリコンBの構造について
    富永 敏夫
    1953 年 73 巻 11 号 p. 1175-1179
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The Aglycone B (I), m.p. 231-232°, extracted from the bark of Engelhardtia formosana Hay correspond to formula C15H12O6, gives a tetraacetate (amorphous) of m.p. 50°, C15H8O6(CH3CO)4⋅H2O, pentaacetate (amorphous) of m.p. 200°, C15H7O6(CH3CO)5, monomethyl ether of m.p. 171-172°, C15H11O5(OCH3), dimethyl ether of m.p. 189-190°, C15H10O4(OCH3)2, trimethyl ether (IV) (amorphous) of m.p. 60°, C15H9O3(OCH3)3, tetramethyl ether (VII) (amorphous) of m.p. 50°, C15H8O2(OCH3)4, and tetrabenzoate (amorphous) of m.p. 130°, C15H8O6(COC6H5)4. Air oxidation of hot aqueous solution of (I) gave 3, 5, 7, 4′-tetrahydroxyflavone (kaempferol) (II), and dehydrogenation of trimethyl ether (IV) with palladium-black and cinnamic acid or application of approximately equimolar amount of alkali to the methanolic solution of (IV), yielded 3-hydroxy-5, 7, 4′-trimethoxyflavone (V). Application of alcoholic potash to the tetramethyl ether (VII) gave α-methoxychalcone (VIII). It was assumed from these experimental results that the structure of Aglycone B would be 3, 5, 7, 4′-tetrahydroxyflavanone (I″).
  • ラセミ・アグリコンBの合成
    富永 敏夫
    1953 年 73 巻 11 号 p. 1179-1182
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Reduction of 3, 5, 7, 4′-tetrahydroxyflavone (kaempferol) with sodium hydrosulfite by the method of Pew gave rac-3, 5, 7, 4′-tetrahydroxyflavone (II) as colorless needles, m.p. 231-232°. This substance was identical in properties and melting point with the racemic compound obtained by boiling Aglycone B with hydrochloric acid. Some time ago, Kimura obtained 3-hydroxy-5, 7, 4′-trimethoxyflavanone, related to (II), by the cyclization of 2′-hydroxy-4, 4′, 6′-trimethoxy-α-methoxychalcone (III) but the substance obtained above was found by the present experiments to be 2-hydroxy-4, 6-dimethoxy-2-(4′-methoxybenzyl)-coumaranone (V), and this reaction was found to be accompanied by the formation of 2, 4, 6-trimethoxy-2-(4′-methoxybenzyl)-coumaranone (IV), m.p. 127°. Application of acetic anhydride and conc. sulfuric acid to (V) yielded 2-acetoxy-4, 6-dimethoxy-2-(4′-methoxybenzyl)-coumaranone (VI), m.p. 135-136°, and 4, 6, 4′-trimeth-oxybenzalcoumaranone (VII), m.p. 166-167°. Confirmation of (VII) was made by its preparation from 2′-hydroxy-4′, 6′, 4-trimethoxychalcone by treatment by the Oyamada method in accordance with the Geissmann-Fukushima method.
  • ペニシリンとパラアミノメチルフェニルスルホン誘導体との塩について
    立岡 末雄, 人見 弘, 川島 實, 碓井 義郎
    1953 年 73 巻 11 号 p. 1183-1185
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Salts of penicillin with p-aminomethylphenyl sulfone monomethylamide, dimethylamide, diethylamide, and p-aminomethylphenyl methyl sulfone were prepared. The p-aminomethylphenyl sulfone diethylamide salt of penicillin was found to be extremely sparingly soluble in water and the effective blood level in rabbit was found to be maintained for over 50 hours.
  • 川谷 豊彦, 藤田 早苗之助, 大野 忠郎, 久保木 憲人, 青柳 喜典
    1953 年 73 巻 11 号 p. 1185-1189
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Cultivation tests on Japanese summer and autumn buckwheat (Fagopyrum esculentum Moench var. aestivum and var. autumnale Makino), diploid and tetraploid buckwheat, and Tartary buckwheat (F. tataricum Gaertner) were carried out at Kasukabe during 1951 for the purpose of examining rutin-content. Relationship between the sowing time and yield of crop, rutin-content, and yield of rutin per 10 ares was chiefly examined with the diploid, tetraploid, and Tartary buckwheat. The results obtained were as follows:
    1) Both the rutin-content and yield of rutin per 10 ares were larger in the summer and autumn buckwheat cultivated in the spring than those cultivated in autumn, and it was confirmed that the spring cultivation of autumn buckwheat gave better results than that of summer buckwheat (cf. Tables I and II).
    2) Both rutin-content and yield of rutin per 10 ares were found to be larger in the diploid and tetraploid buckwheat cultivation during the spring than those sown in autumn. Comparison of the diploid and tetraploid cultivation at the same time showed no re-markable difference in the yield of crop per 10 ares but the rutin-content and yield of rutin per 10 ares were smaller in the tetraploid (maxima, 3.21% and 1.693kg.) than in the diploid (maxima, 5.61% and 3.589kg.) (cf. Table III).
    3) Tartary buckwheat gave better results in the point of fresh useful crop than the summer and autumn buckwheat. While the yield of fresh crop, rutin-content, and yield of rutin per 10 ares of Tartary buckwheat cultivated during the spring was inferior to those of Japanese buckwheat, those cultivated in the summer and autumn showed better results (cf. Table IV).
  • 山口 一孝, 太幡 利一, 伊東 宏
    1953 年 73 巻 11 号 p. 1189-1192
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Aqueous solution of berberine hydrochloride shows absorption maxima at 227.5, 262.5, 345, and 420mμ
    2) Light absorption (e) was measured by the Beckmann spectrophotometer at 420mμ (l=1cm.) in different concentrations (γ/100cc.). The following experimental equation was calculated by the method of least squares from these data:
    γ=7023e+25.19......(1) Limit of error (2σ): ±113γ
    as berberine γ=6610e+25.19......(2) Limit of error (2σ): ±98γ
    3) Berberine in crude drugs was measured by the three following methods: (A) e420mμ of the acidified aqueous extract; (B) e420mμ of the diluted hydrochloric acid solution of the isolated berberine hydriodide; and (C) acetone-berberine method of J.P. VI.
    4) The values obtained from the above three methods agreed well, and the rate of detectable berberine by respective method is 92.5% (A), 90.4% (B), and 90.0% (C).
  • Rhodea-Sapogeninの構造 その1
    那波 速男
    1953 年 73 巻 11 号 p. 1192-1194
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Hydrolysis of the saponin, isolated from the leaf of Rhodea japonica Roth, gave a sapogenin, m.p. 293-295° (decomp.), corresponding to formula C27H44O4. This sapogenin does not precipitate with digitonin but undergoes isomerization by alcoholic hydrochloric acid. From these and the fact that it easily gives a monobromo substitutent, it was assumed to be a dihydroxysteroidal sapogenin possessing a normal spiroketal side chain.
  • Rhodea-Sapogeninの構造 その2
    那波 速男
    1953 年 73 巻 11 号 p. 1195-1197
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was confirmed by infrared spectral analysis that rhodea-sapogenin and rhodea-isosapogenin are steroidal sapogenins respectively possessing normal and isospiroketal side chain. At the same time, rhodea-sapogenin diacetate was decomposed to pregnenolone (or allopregnenolone) derivative through pseudo compound. The pregnenolone or al-lopregnenolone thereby obtained also failed to precipitate with digitonin.
  • Rhodea-Sapogeninの構造 その3
    那波 速男
    1953 年 73 巻 11 号 p. 1197-1200
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Rhodea-sapogenin, C27H44O4, a dihydroxysteroidal sapogenin possessing a normal-type spiroketal side chain, submits to chromic acid oxidation and gives rhodea-sapogenic acid, C27H42O6, a dicarboxylic acid formed by cleavage at C2-C3. Since rhodea-isosapogenin is not identical with either gitogenin or its C2, C3-isomer, rhodea-sapogenic acid was assumed to be identical with texogenic acid. Since both rhodea-sapogenin and its derivative, 16-pregnen-2, 3-diol-20-one do not precipitate with digitonin nor form acetonides, rhodea-sapogenin must possess spirostan-2β, 3α-diol structure.
  • 五倍子タンニンの微量定量
    木村 康一, 桑野 重昭, ヒキノ ヒロシ, 飯田 才一, 上田 昌男, 眞鍋 貞子, 伊田 順子
    1953 年 73 巻 11 号 p. 1200-1203
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    During the course of revaluation of tannin-bearing drugs, microanalytic method for gallotannins was followed in order to find their effect in human body, especially their change in the intestines. Satisfactory results were obtained by the modified Hagendorn-Jensen method, used in the determination of blood sugar, as well as with colorimetric method with ammonium molybdate.
  • 五倍子タンニンの卵白アルブミンによる分劃の試み
    木村 康一, 桑野 重昭, ヒキノ ヒロシ
    1953 年 73 巻 11 号 p. 1204-1206
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Gallotannin was fractionated with egg albumin, and extracted the combined tannin and egg albumin with 95% alcohol. It was found that tannins of higher polarization did not combine with egg albumin and showed greater mobility than others by the paper electrophoresis. It was assumed that, in order to obtain a clearer images of electrophoretic pattern of gallotannins, the existence of borate was necessary in weak alkalinity.
  • えぞにう果実油の脂肪酸の研究
    黒野 吾市, 酒井 健
    1953 年 73 巻 11 号 p. 1207-1209
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Crude fatty acids were obtained in approximately 15% yield from the fruits of Angelica ursina Benth. et Hook. The distillation of the methyl esters of the acids at 3mm. pressure gave Fractions (A), (B), and (C) (cf. Table I). (A) Fraction failed to yield any acid substance. About 42% of solid and about 58% of liquid fatty acids were respectively isolated from (B) and (C) Fractions by the lead salt method. Palmitic acid, m.p. 60-61°, was obtained from Fraction (B), and crystals of m.p. 27-28° from Fraction (C). From the results of elemental analyses, elaidination, and paper chromatography, the crystals were found to be a mixture of petroselic and petroselidic acids. Permanganate oxidation of the liquid acid yielded 6, 7-dihydroxy- and 9, 10, 12, 13-tetra-hydroxystearic acids. These experimental results showed that the fatty acids composing the fruit oil of Angelica ursina are petroselic, petroselidic, palmitic, and linolic acids.
  • みしまさいこ果実油の脂肪酸の研究
    黒野 吾市, 酒井 健, 石田 知子
    1953 年 73 巻 11 号 p. 1209-1211
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Crude fatty acids were obtained in approximately 9.3% yield from the fruit of Bupleurum falcatum L. Distillation of the methyl ester of these acids at 4mm. pressure gave Fractions (A) and (B) (Table I). Both (A) and (B) fractions were respectively isolated into about 28% of solid and about 72% of liquid acids. (A) fraction gave crystals of m.p. 28.5-29° which were found to be a mixture of petroselic and petroselidic acids from the results of elemental analyses, elaidination, and paper chromatography. Fraction (B) yielded crystals of m.p. 29-30°, whose elemental analyses, elaidination, and paper chromatography showed it to be petroselic acid with a minute amount of petroselidic acids. Oxidation of the liquid acid by the Hazula method gave 9, 10, 12, 13-tetrahydroxystearic acid from which the fatty acids composing the fruit oil of Bupleurum falcatum were found to be petroselic, petroselidic, and linolic acids.
  • ながじらみ, おおかさもち及びいぶきぼうふう果実油の脂肪酸の研究
    黒野 吾市, 石田 知子
    1953 年 73 巻 11 号 p. 1211-1213
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Since the raw materials could not be obtained in a large amount, the fatty acids of the fruit oil of Osmorhiza aristata Makino et Yabe, Pleurospermum kamtschaticum Hoffm., and Seseli libanotis Koch var. daucifolia Franch et Sav., were led to the hydroxamic acids, and were submitted to qualitative estimation of each fatty acid using the circular paper chromatography similar to that described in Part VIII of this series. The fatty acids from the fruit oil of the first two plants were separated preliminarily into solid and liquid acids, and each was chromatographed as its hydroxamic acid. From each were obtained petroselic, petroselidic, palmitic, oleic, and linolic acids. Since the amount of Seseli fruit oil was so small it could not be separated into liquid and solid acids and was therefore derived to the hydroxamic acid, per se, and chromato-graphed. Only the presence of petroselic and linolic acid was confirmed.
  • 果実油脂肪酸中ペトロセリヂン酸の存在に就いて
    黒野 吾市
    1953 年 73 巻 11 号 p. 1213-1216
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    In the previous papers of this series, the writer reported the finding of the presence of petroselidic acid, the trans isomer of petroselic acid, with the latter in the fruit oil of Umbelliferae plants. It was also shown in Part VI that petroselic acid in the fruit oil underwent gradual elaidination to petroselidic acid by the action of ultraviolet light but that such elaidination never occurred by the processes of extraction and isolation. It was therefore concluded that the petroselidic acid detected in fruit oil had been formed by the gradual elaidination of petroselic acid by the ultraviolet rays in the sunlight because there had been no example of the presence of a trans-type fatty acid of oleic acid series in plants. However, isolation of a mixture of petroselic and petroselidic acids as crystals of m.p. 27-28.5° and of m.p. 29-31°, respectively, from the unripe fruit of Angelica ursina Benth. et Hook. and Bupleurum falcatum L., has shown clearly that a minute amount of petroselidic acid was present originally with petroselidic acid in the fruit. It was also clarified that petroselidic acid was present in the fruit oil of Daucus carota L., Apium graveolens L., Petroselinum sativum Hoffm., and Cryptotaenia japonica Hassk.
  • ピクリル化合体の合成
    木村 道也
    1953 年 73 巻 11 号 p. 1216-1218
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Ethyl α-(2, 4, 6-trinitrophenyl)-acetoacetate, m.p. 97-98°, (2, 4, 6-trinitrophenyl)-acetone, m.p. 77-78°, ethyl α-(2, 4, 6-trinitrophenyl)-benzoylacetate, m.p. 154-155°, and ω-(2, 4, 6-trinitrophenyl)-acetophenone, m.p. 134-135°, were prepared and their Rf values were determined by paper chromatography. Absorption spectra of their alkaline coloration were determined and it was found that the absorption maximum in the visible range was present only at 515mμ.
  • アルカリ存在下の1,3,5-トリニトロベンゼンとメチルケトンとの反応に就いて
    木村 道也
    1953 年 73 巻 11 号 p. 1219-1223
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Condensation of 1, 3, 5-trinitrobenzene and methyl ketones (acetone and acetophenone) in the presence of alkali gave some black needle crystals which showed an absorption spectrum similar to that of color reaction produced by 1, 3, 5-trinitrobenzene and active methylene compound in the presence of alkali. This complex decomposes into respective components in an acid solution but in the presence of hydrogen peroxide, 1, 3, 5-trinitro-benzene cannot be obtained and the picryl compound of the active methylene group is formed. Results of paper chromatographic observation showed that the active methylene group in the complex molecule had a tendency to undergo partial substitution with other active methylene compound when they come into contact. From these facts and from the values of elemental analyses and molecular weight determination, it was concluded that the structure of the above complexes should be respresented by formulae (VII) and (VIII).
  • プロピオフェノン, 3,4-メチレンヂオキシプロピオフェノンの合成
    平尾 一郎
    1953 年 73 巻 11 号 p. 1224-1226
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Phenylethynylcarbinol, prepared by the alkynol synthesis of benzaldehyde and acetylene, was reduced to phenylethylcarbinol and subsequently oxidized to propiophenone. In a similar manner, 3, 4-methylenedioxypropiophenone was synthesized from piperonal. Hydrolysis of phenyl ethynyl ketone gave benzoyl methyl ketone.
  • Colchicine及びSubstance Fの分離
    上農 義雄
    1953 年 73 巻 11 号 p. 1227-1229
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The corm of a garden variety meadow saffron, Colchicum autamnale L.; of white flower, was harvested during the early part of September. From the dried corm were extracted 0.114% of an alkaloid of colchicine series which Santavy designated as Substance F, 0.034% of colchicine, and 2.5% of sucrose.
  • Substance Fの誘導体 その1
    上農 義雄
    1953 年 73 巻 11 号 p. 1230-1232
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Following derivatives were prepared from Substance F, m.p. 183-185°, C21H25O5N, isolated from white meadow saffron corm. Monoacetate (II), m.p. 227-229°, [α]D17: -232°, C23H27O6N; monomethyl compound (III), m.p. 200-203°, [α]D20: -106°, C22H27O5N; nitroso compound (IV), m.p. 187-190°, [α]D20: -99°, C21H24O6N2. Hydrolysis of Substance F with diluted hydrochloric acid gave the demethylated compound (V), m.p. 132-135°, [α]D17: -226°, C20H23O5N. Similar hydrolysis of (II) gave C22H25O5N (VI), m.p. 189-190°, [α]D20: -279°, and of (III), C21H25O5 (VII), m.p. 129-131°, [α]D22: -225°. Treatment of Substance F with conc. ammonia yielded an amino compound (VIII), m.p. 128-131° (decomp.), [α]D22: -133°, C20H24O4N2⋅1/2 CH3OH. Amination of (II) in a similar manner gave C22H26O5N2⋅1/2CH3COCH3 (IX), m.p. 122-125° (decomp.), [α]D22: -293°.
  • Substance Fの誘導体 その2
    上農 義雄
    1953 年 73 巻 11 号 p. 1232-1234
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Following derivatives of Substance F were also prepared. Hydrolyses of (VIII) and (IX) with sodium hydroxide solution respectively yielded (V) and (VI). Application of sodium methoxide or methanolic potash to Substance F and (II) respectively gave C20H23O5N (X), m.p. 256-258° (decomp.), [α]D17: -160°, and C22H25O6N (IX), m.p. 283-284° (decomp.), [α]D20: -143°. Acetylation of (X) gave (XI) whose methylation yielded C23H27O6N (XII), m.p. 162-165°, [α]D23: -152°.
  • Substance Fの構造 その1
    上農 義雄
    1953 年 73 巻 11 号 p. 1235-1238
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The structure of the Substance F was assumed from its properties, its derivatives, and the color reactions. In order to prove this structure, N-methyldeacetylcolchiceine, m.p. 129-131°, C21H25O5N, was prepared from colchicine. This substance was found to be identical in melting points and various properties with a substance (VII) of m.p. 129-131°, C21H25O5N, obtained by the hydrolysis with diluted hydrochloric acid of (III), C22H27O5N, formed by the methylation of Substance F. It follows, therefore, that the structure of Substance F may be represented by Formula D or E in Fig. 3.
  • Substance Fの構造 その2
    上農 義雄
    1953 年 73 巻 11 号 p. 1238-1242
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was assumed that the structure of Substance F would be represented by formula D or E in Fig. 1, but the infrared absorption spectrum made it possible to conclude that the structure is N-methyldeacetylcolchicine, represented by formula D (normal). The formation of the various derivatives of Substance F obtained to date and their structures were clarified (Fig. 4). It was also found that Substance F and its derivatives possessed characteristic action against the animal and vegetable cells like that of colchicine.
  • 關屋 實, 大石 喜美子
    1953 年 73 巻 11 号 p. 1243-1244
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was found that aldoximes undergo dehydration when heated with organic amides to form a nitrile. Formamide, acetamide, and p-toluenesulfonamide were used as the organic amide, and their reaction with α-benzaldoxime, p-sulfonamidobenzaldoxime, and butyraldoxime yielded the corresponding nitriles.
  • 山口 一孝, 福島 清吾, 伊藤 みよ子
    1953 年 73 巻 11 号 p. 1245-1247
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Degradation of the total alkaloid contained in ergot fluidextract was observed during 125 days at 0° to 2° and at 25-26°. The alkaloidal content decreased rapidly at 25-26° but no decrease was observed at 0° to 2°. Effect of the addition of stabilizers such as l-ascorbic acid, cysteine hydrochloride, thiourea, and sodium thiosulfate, was found to prevent alkaloidal degradation in the fluidextract, thiourea being especially effective.
  • 富田 眞雄, 久郷 威彦, 平井 義人
    1953 年 73 巻 11 号 p. 1247-1249
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Recently, Backer and Boer recommended the use of N-nitroso-p-toluenesulfone-methylamide (IV) as the starting material for diazomethane. The present writers reëxamined this experiment and its stability, and found (IV) to be more stable than nitrosomethylurethane and nitrosomethylurea, heretofore used as the materials for diazomethane. It was also proved that (IV) could be maintained for a fairly long period, even during the summer months with atmospheric temperature of around 36°, if kept in a closed desiccator, without undergoing decomposition.
  • 竹本 常松, 小池 弘光
    1953 年 73 巻 11 号 p. 1250
    発行日: 1953/11/25
    公開日: 2010/02/19
    ジャーナル フリー
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