巻号一覧
88 巻, 10 号
選択された号の論文の23件中1～23を表示しています
- |<
- <
- 1
- >
- >|
-
岡田 寿太郎, 川島 嘉明1968 年 88 巻 10 号 p. 1251-1255
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーOne of the available methods of measurement of the diffusion coefficient is the porous diaphragm method, which was introduced by Northrup and Anson and developed by McBain and Nakagaki. Their methods are based on diffusion model (1) in Fig. 1, namely they neglected the concentration gradient in liquid phases. We used the diaphragm method also but took the gradient into account, our model (2) is shown in Fig. 2. The equation and the boundary conditions of our model are given by eq. (1). Its solution is given by J. Crank as eq. (2) and (3), where h is constant. Now, h should be dependent upon D. From the consideration of mass transfer, we assumed h=kD and determined k as ca. 0.66 experimentally. So, eq. (3) is converted to eq. (6). Measure of the diffusion coefficient of caffeine in water is found on the graphical Integral of eq. (6).抄録全体を表示PDF形式でダウンロード (495K) -
西海枝 東雄, 谷口 陽一1968 年 88 巻 10 号 p. 1256-1263
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーThe Perkin reaction of 2-thiophenecarboxaldehyde and 2-thiopheneacetic acid afforded two kinds of stereoisomers of 2, 3-bis (2-thienyl) acrylic acid (IV) ; α-form (IVa) and β-form (IVb). Amidation of these compounds produced cis-2, 3-bis (2-thienyl) acrylamide (IVa) and trans-2, 3-bis (2-thienyl) acrylamide (VIb) from IVa and only IVb from IVb. The same reaction of 5-nitro-2-thiophenecarboxaldehyde (X) and 2-thiopheneacetic acid also afforded two isomers of 2-(2-thienyl)-3-(5-nitro-2-thienyl) acrylic acid (III) ; α-form (IIIa) and β-form (IIIb). Amidation of these compounds also afforded the cis-(XIa) and trans-2-(2-thienyl)-3-(5-nitro-2-thienyl) acrylamide (XIb) from IIIa and only XIb from IIIb. That these compounds were mutual stereoisomers was proved by the measurement of ultraviolet (UV) and infrared (IR) absorption spectra, and dipole moments.抄録全体を表示PDF形式でダウンロード (793K) -
藤川 福二郎, 中村 泰三, 西牧 敏子, 白井 邦子, 松井 清, 横山 年子, 内藤 益一, 津久間 俊次1968 年 88 巻 10 号 p. 1264-1269
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーA total of 62 kinds of compounds to be derived from lichen components by decomposition were synthesized. These included 25 kinds of orcilaldehyde derivatives, 8 kinds of β-orcilaladehyde derivatives, 7 kinds of atranol derivatives, and 22 kinds of divaraldehyde derivatives. Antibacterial action of these compounds were tested with human type tubercle bacilli, the sensitive H37RvS strain and the resistat H37RvR strain which is resistant to over 300 μg/ml of streptomycin, 50 μg/ml of p-aminosalicylic acid, and 50 μg/ml of INAH. None of the compounds tested had antibacterial action against these two strains.抄録全体を表示PDF形式でダウンロード (630K) -
小澤 光, 原 洋一1968 年 88 巻 10 号 p. 1270-1276
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーTachyphylaxis to the effects of 2-(2-diethylaminoethyl)-1-phenylisothiuronium bromide hydrobromide (DEPT), one of the 2-aminoethylisothiuronium (AET) derivatives, has been studied on the blood pressure of anesthetized rat and spinal cat, and also on the nictitating membrane of the cat. The pressor responese to DEPT declined gradually with successive injections ; the extent of tachyphylaxis induced by DEPT depended on the dosage and on the frequency of injections. But a complete depression could not be observed after 25 injections with this compound. The tachyphylaxis induced by DEPT is not crossed to tyramine or amphetamine, and is not recovered with noradrenaline infusion. Tachyphylaxis induced by tyramine in normal animals is recovered with noradrenaline infusion, but is not recovered with noradrenaline infusion after treatment with nialamide, a drug which inhibits monoamine oxidase, or large does of DEPT. In animals treated with nialamide, the tachyphylaxis induced by DEPT was similar to that in normal animals, but the tachyphylaxis to tyramine was induced more rapidly after treatment with nialamide and was similar to that produced by amphetamine in normal animals. These results mentioned above indicated that the tachyphylaxis mechanism of DEPT might be different from that of tyramine or amphetamine. Effects of reserpine, cocaine, guanethidine, bretylium, hexamethonium and tetraethylammonium to the pressor response of DEPT in urethane anesthetized rat were also investigated.抄録全体を表示PDF形式でダウンロード (839K) -
森田 直賢, 清水 岑夫, 竹崎 孝行1968 年 88 巻 10 号 p. 1277-1280
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーA new glycoside (I), C24H26O18·11/2H2O, mp 274-275°, was isolated from Chrysosplenium grayanum MAXIM. (Japanese name"Nekonomeso"), and a glycoside (II), C24H26O12·2H2O, mp 175-176°, from C. flagelliferum FR. SCHM. (Japanese name"Tsurunekonomeso"). I was determined as oxyayanin-A (5, 2', 5'-trihydroxy-3, 7, 4'-trimethoxyflavone)-2'-glucoside, and was named chrysosplenoside-A, and II as pendulin (5, 4'-dihydroxy-3, 6, 7-trimethoxyflavone-4'-glucoside).抄録全体を表示PDF形式でダウンロード (594K) -
西岡 五夫, 松尾 律子, 大倉 洋甫, 百瀬 勉1968 年 88 巻 10 号 p. 1281-1285
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーA new colorimetric method for microdetermination of isothiocyanates was established, using 3, 6-dinitrophthalic acid as a color developing agent in a potassium carbonatesodium thiosulfate solution. The reaction conditions were examined with allyl isothiocyanate as a model compound. The outline of the procedure is as follows : To 2.0 ml of allyl isothiocyanate solution (10-150 μg/ml), (dissolved in 50% ethylene glycol solution, 1.0 ml of 3, 6-dinitrophthalic acid monopyridinium salt solution (0.1%), and 1.0 ml of alkaline solution (40% potassium carbonate and 30% sodium thiosulfate) are added and mixed well. The mixture is heated in a boiling water bath for exactly 10 minutes, cooled in running water, and diluted to 20.0 ml with water. The absorbance of the developed color is read at 400 mμ against the reagent blank. In this color reaction, 3, 6-dinitrophthalic acid was assumed to be reduced to 3-amino-6-nitrophthalic acid by S2-, which was liberated from allyl isothiocyanate in the alkaline medium.抄録全体を表示PDF形式でダウンロード (631K) -
佐々木 喜男, 恩地 亨輔1968 年 88 巻 10 号 p. 1286-1288
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーThe minor alkaloids, michelalbine, C23H25O6N, mp 194-195°, stepharine, and C27H33O11N, mp 94-97°, were isolated from Sinomenium acutum REHD. et WILS.抄録全体を表示PDF形式でダウンロード (433K) -
斎藤 徳男, 栗原 拓史, 山中 清行, 鶴田 聰, 安田 貞夫1968 年 88 巻 10 号 p. 1289-1292
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリー2-(p-Aminophenyl)-5-bromo-4-methyloxazole (XIII) and 4-bromo-, 4-iodo-5-methyl-2-sulfanilamidoisoxazole (VII, XVII) were synthesized by direct bromination or iodination of 2-(p-acetamidophenyl)-4-methyloxazole (XII) and 5-methyl-3-(N4-acetylsulfanilamido) isoxazole (XIV), followed by deacetylation, in good yield.抄録全体を表示PDF形式でダウンロード (490K) -
竹本 常松, 小川 俊太郎, 西本 喜重, 平山 瞳, 谷口 忍1968 年 88 巻 10 号 p. 1293-1297
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーEcdysterone (I) and inokosterone (II) were isolated and identified from the terrestrial portion of Achyranthes fauriei, whole herb of A. japonica, root of A. bidentata (crude drug of Chinese origin) and its Japanese cultivated species (Hitachi Goshitsu), root of Formosan A. rubrofusca, and whole herb of Formosan A. longifolia. Only I was isolated from the terrestrial portion of Formosan A. obtusifolia and whole herb of Formosan Cyathula Prostrata.抄録全体を表示PDF形式でダウンロード (628K) -
沼田 敦, 鈴木 隆, 大野 孝正, 上尾 庄次郎1968 年 88 巻 10 号 p. 1298-1305
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーFor the purpose of establishing the absolute configuration of enmein (I) by chemical means, (-)-6-methyl-7-oxobicyclo [3. 2. 1] octane (VIII) was prepared by a sequence of reactions shown in Chart 3 and 5. The synthesized compound was found to be an enantiomer of the compound (XXXIII) obtained by pyrolysis of disdehydrodihydroenmein. Since the absolute configuration of VIII is deduced from that of the intermediate (XXIIIb), the absolute configuration of the pyrolysis product (XXXIII) has been clarified. The result thus obtained is in agreement with the absolute configuration of enmein proposed in in the previous paper.抄録全体を表示PDF形式でダウンロード (919K) -
西海枝 東雄, 松尾 純郎1968 年 88 巻 10 号 p. 1306-1310
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーIn the reaction of dimethyl sulfoxide with 2-furyl bromomethyl ketone (Ia), 5-nitro-2-furyl bromomethyl ketone (Ib), and 4-bromophenacyl bromide (Ic) at room temperature, methyl 2-furoylthiol formate (IIIa), methyl 5-nitro-2-furoylthiol formate (IIIb), and methyl 4-bromobenzoylthiol formate (IIIc) were newly isolated besides 2-furylglyoxal (IIa), 5-nitro-2-furylglyoxal (IIb), and 4-bromophenylglyoxal (IIc). Variation in the amounts of IIa, b, c and IIIa, b, c formed was examined by gas chromatography while varying the reaction temperature and time.抄録全体を表示PDF形式でダウンロード (591K) -
森田 直賢, 清水 岑夫, 内田 節子1968 年 88 巻 10 号 p. 1311-1312
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーA new glycoside, mp 248-251°, was obtained from the leaves of Staphylea Bumalda DC. (Japanese name'Mitsuba-Utsugi'). This substance gave a dark purple color to ferric chloride reaction, was negative to the flavone reaction, and the presence of a carbonyl group and a conjugated double bond was presumed from its infrared spectrum. Hydrolysis with 10% sulfuric acid afforded 2 moles of glucose and an aglycone as pale yellow prisms, mp 269-270°, which formed a diacetate of mp 134-136°. The NMR spectrum of the aglycone suggested it to be 2-methyl-5, 7-dihydroxychromone (noreugenin), and the fact was confirmed by mixed fusion and comparison of the infrared spectra with the synthesized sample. It follows, therefore, that this glycoside is noreugenin 7-diglucoside and was named staphylin.抄録全体を表示PDF形式でダウンロード (373K) -
田中 照夫, 田中 秀雄, 椿 紀恭1968 年 88 巻 10 号 p. 1313-1317
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーFrom the acetonation product of riboflavin, several new O-isopropylidene derivatives of riboflavin were isolated. Periodate oxidation of mono-O-isopropylidene derivatives and riboflavin dibenzoates derived from mono-O-isopropylidene compounds showed that the structures of these O-isopropylidene derivatives are 2' : 4', 3' : 5'-di-O-isopropylideneriboflavin (II), 4' : 5'-O-isopropylideneriboflavin (III), 3' : 4'-O-isopropylideneriboflavin (IV), and 2' : 3'-O-isopropylideneriboflavin (V). Partial hydrolysis of II and 2' : 3', 4' : 5'-di-O-isopropylideneriboflavin (I) afforded 2' : 4'-O-isopropylideneriboflavin (VI) and V respectively.抄録全体を表示PDF形式でダウンロード (507K) -
岡田 寿太郎, 中野 功一, 矢本 真人, 斎藤 佳介1968 年 88 巻 10 号 p. 1318-1322
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーGas phase dehydration of isoamylalcohol on spherical alumina catalyst was studied by a packed bed reactor. The reaction was operated under the constant conditions of 350°and the atmospheric pressure. The main products were 3-methyl-1-butene, 2-methyl-1-butene, 2-methyl-2-butene and water, and we could neglect the other byproducts for our calculation. The reverse process of dehydration reaction might be neglected. By the analysis of our results (Fig 3, 4), this dehydration reaction was summarised as equations (7)-(12), and we determined the rate-constants from our results.抄録全体を表示PDF形式でダウンロード (504K) -
木本 正七郎, 岡本 正夫, 矢部 格子, 内田 貴子, 松高 佳子1968 年 88 巻 10 号 p. 1323-1328
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーSyntheses of cis- and trans-10-amino-11-hydroxy-10, 11-dihydrodibenzo [b, f] thiepin and their derivatives are described. Their steric configurations are clarified by using desulfurization reaction with Raney nickel.抄録全体を表示PDF形式でダウンロード (727K) -
奥田 拓男, 小西 邦弘1968 年 88 巻 10 号 p. 1329-1332
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーCoriose (D-altro-3-heptulose) (I), sedoheptulose (II), methyl α-D-galactoside (III) and myo-inositol (V) were isolated from the methanol extract of red fruit of Coriaria japonica after removing tutin by extraction with chloroform, and also glucose and fructose etc. by fermentation, treating with ion-exchange resins, and then passing through a charcoal-Celite column. Volemitol (IV), I and V were isolated from seed of red fruit. The mother liquor of coriamyrtin extract from leaf and stems gave I and V. The presence of these constituents in the plant has been confirmed by paper partition chromatography of the juice pressed from fresh fruit and stem, and also by gas liquid chromatography of trimethylsilyl ether. Distribution of the other sugar constituents was also investigated.抄録全体を表示PDF形式でダウンロード (584K) -
林 英作, 大石 悦男, 手塚 忠夫, 江間 公子1968 年 88 巻 10 号 p. 1333-1337
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーN-oxidation of 1-methyl-(I) and 1-benzyl-phthalazine (II) was attempted at lower than 10° in the mixed solvents of chloroform and ether using monoperphthalic acid. 2-Oxide (I2) and 3-oxide (I3) were produced from I in a 1 : 2 ratio and from II 2-oxide (II2) and 3-Oxide (II3) in almost a 3 : 1 ratio. The position of N-oxide groups were determined by the following procedures. To I2 and I3, phenylmagnesium bromide was reacted respectively and the reaction solution was treated with p-benzoquinone to 2-oxide (III2) and 3-oxide (III3) of 1-methyl-4-phenylphthalazine (III). III2 was confirmed by the synthesis separately carried out in reacting 1-phenylphthalazine 3-oxide (IV3) with methylmagnesium iodide. Therefore, the structure of I2 was decided and that of I3 might be suggested. Similar procedures were made in the determination of the structures of II2 and II3. It was reported that only 2-oxide (III2) was produced from 1-methyl-4-phenylphthalazine (III) and that from 1-isopropyl-4-phenylphthalazine (VII), only 3-oxide (VII3) was produced (Chart 3). N-oxidation of 1-ethyl-4-phenylphthalazine (IX) was attempted and only 2-oxide (IX2) was obtained (Chart 4).抄録全体を表示PDF形式でダウンロード (642K) -
福田 英臣, 渡辺 和夫, 工藤 佳久, 大島 隆1968 年 88 巻 10 号 p. 1338-1343
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーCrossed extensor reflexes of the leg were elicited by stimulation of the contralateral n. fibularis in the anesthetized and in the spinal chickens. Dose-response curves of several central muscle relaxants and of some central nervous system stimulants were obtained. Mephenesin and meprobamate depressed the reflex in the non-spinal chicks in the same degree as in the spinal ones, suggesting that the spinal cord was the main site of action of these drugs. Diazepam, chlordiazepoxide and carisoprodol depressed the reflex stronger in the non-spinal chicks than in the spinal chicks, probably because these drugs affected the brain as well as the spinal cord. Strychnine and picrotoxin showed characteristic stimulating effects. The antagonistic pattern of the relaxants against strychnine was different from that against picrotoxin. From these results it was confirmed that the crossed extensor reflex in the young chicks could be available for the investigation of the central muscle relaxants.抄録全体を表示PDF形式でダウンロード (757K) -
岡田 寿太郎, 川島 嘉明1968 年 88 巻 10 号 p. 1344-1348
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーIn a previous paper, we studied the extraction mechanism of caffeine from crushed tealeaf and determined the mass transfer coefficients of diffusional, capillary and washing extractions. In this paper, tropine alkaloid is extracted from slices of Scopoliae Rhizoma cut to various sizes in water and buffer (pH 4, 5, 6). In this case, capillary extraction does not take a part, because extraction rate is independent on agitation. Then, extraction takes place by washing and diffusion mechanisms. We determine the mass transfer coefficient of these two mechanisms by analysis of the extraction rate, which depends distinctly on pH of the solvent (Table III).抄録全体を表示PDF形式でダウンロード (483K) -
清水 岑夫, 森田 直賢1968 年 88 巻 10 号 p. 1349-1351
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーA new glycoside (I), C25H28O13·2H2O, mp 226-228°, [α]20D-30° (c=0.2, pyridine) was isolated from Chrysosplenium tosaense MAKINO (Japanese name"Tachinekonomeso"). I was assumed to be 5, 4'-dihydroxy-3, 6, 7, 3'-tetramethoxyflavone 4'-monoglucoside and was named chrysosplenoside-B.抄録全体を表示PDF形式でダウンロード (426K) -
小澤 光, 久保田 克已, 原 洋一1968 年 88 巻 10 号 p. 1352-1355
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーPharmacological properties of 2-aminoethyl-1-p-chlorophenylisothiuronium bromide hydrobromide (AEPCIT), one of the 2-aminoethylisothiuronium (AET) derivatives, were examined and compared with those of 2-aminoethyl-1-phenylisothiuronium bromide hydrobromide (AEPhT). AEPCIT possessed slightly stronger adrenergic α-blocking action and local anesthetic, antispasmodic actions than AEPhT. While AEPCIT showed the marked negative inotropic action on isolated heart of guinea pig, the positive inotropic and chronotropic actions were observed on the vagotomized open chest dog. Acute toxicity was also tested.抄録全体を表示PDF形式でダウンロード (498K) -
木村 雄四郎, 滝戸 道夫, 山内 盛1968 年 88 巻 10 号 p. 1355-1357
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーTwo flavonoid glucosides were isolated from the stems and leaves of Agrimonia pilosa LEDEBOUR var. japonica NAKAI (Rosaceae), which did not yet bear any flower, by 6-Nylon column chromatography and were identified as luteolin 7-β-D-glucoside and apigenin 7-β-D-glucoside by mixed fusion and IR spectra. Its whole herb is in general called Ryugeso.抄録全体を表示PDF形式でダウンロード (472K) -
富松 利明, 橋本 美津子1968 年 88 巻 10 号 p. 1357-1359
発行日: 1968/10/25
公開日: 2008/05/30
ジャーナル フリーBy the ether extraction of the syrupy portion from the methanol extract of Poncirus trifoliata RAFINESQUE, four kinds of compound such as seselin (mp 119-120°), marmesin (mp 185-186°) and β-sitosterol (mp 136-137°), as well as γ-sitosterol have been isolated in crystalline state for the first time from the plant.抄録全体を表示PDF形式でダウンロード (489K)
- |<
- <
- 1
- >
- >|