Inhibition of the growth of tubercle bacilli,
in vitro, was effectively shown in 400, 000-800, 000 dilution of sodium
p-aminosalicylate, 40, 000 dilution of 4-acetylamino-benzaldehyde thiosemicarbazone, and in 12, 800, 000 dilution of isonicotinic acid hydrazide, all used as the control, while 2, 4-dihydroxy-5-hexylbenzalisonicotinic acid hydrazone, one among the 64 compounds tested, effectively prevented growth in 2, 560, 000 dilution. The esters of
p-aminosalicylic acid, reported in Part VI of this series, were again test-ed and some of them were found to possess powerful growth inhibitory action, as the following effectively prevented growth at respective dilutions: Phenyl ester at 5, 120, 000-12, 800, 000,
o-tolyl ester at 2, 560, 000,
p-tolyl ester at 2, 560, 000-6, 400, 000,
m-tolyl ester at 1, 280, 000-6, 400, 000,
o-methoxyphenyl ester at 6, 400, 000, and
p-methoxyphenyl ester at 6, 400, 000-12, 800, 000. Other compounds showed only a weak growth-preventive activity.
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