Four alcholic metabolities of (±)-3-chloro-5-[3-(2-oxo-1, 2, 3, 5, 6, 7, 8, 8a-octahydroimidazo [1, 2-a] pyridine-3-spiro-4'-peperidino) propyl]-10, 11-dihydro-5H-dibenz [b, f] azepine (mosapramine), a new antipsychotic drug, were synthesized in order to determine their chemical structures. A mixture of 10-ethoxy-3-chloro-10, 11-dihydro-5H-dibenz [b, f] azepine and 11-ethoxy isomer was used as a starting material. Isomeric intermediates, i. e. 10-oxo-3-chloro-5-(3-chloropropyl)-10, 11-dihydro-5H-dibenz [b, f] azepine and 11-oxo isomer, were separated by chromatography with silica gel. The metabolites were obtained by NaBH
4 reduction of the corresponding 10-oxo or 11-oxo compounds followed by introduction of spiro-piperidine moieties into propyl side chain.
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